Search results for "Pain"
showing 10 items of 6371 documents
Interventional treatment for neuropathic pain due to combined cervical radiculopathy and carpal tunnel syndrome: a case report
2017
Key Clinical Message The coexistence of median and cervical nerve root damage might hide a complex pathophysiology. Here, we describe and discuss the case of a patient suffering from numbness and painful tingling of the hand, whose symptoms were effectively treated with pulsed radiofrequency and epidural administration of bupivacaine and morphine.
Pasteurized C1 inhibitor concentrate in hereditary angioedema: pharmacology, safety, efficacy and future directions
2010
Hereditary angioedema (HAE) is a relatively rare genetic disorder that is most commonly caused by a deficiency of C1 inhibitor. It is estimated that HAE affects at least one in 10,000 to one in 50,000 of the worldwide population, with relapsing swelling of the skin and abdominal pain attacks being the most common clinical symptoms. Most seriously, laryngeal edema associated with HAE may lead to death. Replacement therapy with intravenous pasteurized C1 inhibitor concentrate is the recommended treatment for acute attacks of HAE, resulting in a rapid resolution of symptoms. Pasteurized C1 inhibitor concentrates can also be used for prophylaxis of HAE, and are currently also being assessed for…
Validation of Knee KL-classifying Deep Neural Network with Finnish Patient Data
2021
Osteoarthritis (OA) is the most common form of joint disease in the world. The diagnosis of OA is currently made by human experts and suffers from subjectivity, but recently new promising detection algorithms have been developed. We validated the current state-of-the-art KL-classifying neural network model for knee OA using knee X-rays taken from postmenopausal women suffering from knee pain attributable to OA. The performance of the model on the clinical data was considerably lower compared to the previous results on population-based test data. This suggests that the performance of the current grading methods is not yet adequate to be applied in clinical settings. The present results also …
The evolution of breast cancer mortality and morbidity in Spain (1977?1988)
1996
A study of breast cancer mortality and cancer morbidity has been carried out in Spain recently for the period 1977-1988, covering the population of the 17 Autonomous Communities and 50 provinces of the country. Data was obtained from INE, Instituto Nacional de Estadística (National Institute of Statistics), with age standardization using the indirect method. The different Autonomous Communities and provinces were compared in order to establish possible significant differences. The crude mean mortality rate was 21 cases per 100,000 inhabitants/year; Las Palmas, Gerona, Barcelona, the Balearic Islands, Navarra and Zaragoza have the highest mortality rates, with a proportional increment of 54%…
New Risk Score for Patients With Acute Chest Pain, Non-ST-Segment Deviation, and Normal Troponin Concentrations
2005
Objectives The purpose of this research was to develop a risk score for patients with chest pain, non-ST-segment deviation electrocardiogram (ECG), and normal troponin levels. Background Prognosis assessment in this population remains a challenge. Methods A total of 646 consecutive patients were evaluated by clinical history (risk factors and chest pain score according to pain characteristics), ECG, and early exercise testing. ST-segment deviation and troponin elevation were exclusion criteria. The primary end point was mortality or myocardial infarction at one year. The secondary end point was mortality, myocardial infarction, or urgent revascularization at 14 days (similar to the Thrombol…
LOW BACK PAIN IN YOUNG TEAM SPORT PLAYERS: A RETROSPECTIVE STUDY
2014
Background Low back pain (LBP) is a common complaint in general population affecting both genders and almost all age-groups. LBP is a common problem in sports as well, even in younger populations. LBP is prone to recur, thus there is a need for studies on the early phases of the problem in different sports. Objective To investigate the prevalence, nature, severity and risk factors of self-reported LBP in young team sport players. Design A retrospective cross-sectional study. Setting Finnish female and male basketball, floorball, ice hockey and volleyball teams. Participants This study is a part of an ongoing cohort study exploring risk factors for sports injuries. Players from 22 teams, a t…
Frovatriptan vs almotriptan for treatment of menstrual migraine: a double-blind, randomized, cross-over, multicenter Italian study
2013
Results 67 of the 96 female patients of the intention-to-treat population of the main study had regular menstrual cycles and were thus included in this subgroup analysis. 77 migraine attacks classified as related to menses were treated with frovatriptan and 78 with almotriptan. Rate of pain relief at 2and 4-hrs was 36% and 53% for frovatriptan and 41% and 50% for almotriptan (p=NS between treatments). Rate of pain free at 2and 4-hrs was 19% and 47% with frovatriptan and 29% and 54% for almotriptan (p=NS). At 24-hrs, 62% of frovatriptanand 67% of almotriptan-treated patients had pain relief, while 60% vs. 67% were pain free (p=NS). Recurrence at 24-hrs was significantly (p<0.05) lower with f…
Evidence for central sensitization in patients with osteoarthritis pain: A systematic literature review
2014
Hyperexcitability of the central nervous system (CNS) has been suggested to play an important role in the chronic pain experienced by osteoarthritis (OA) patients. A systematic review following PRISMA guidelines was performed to evaluate the existing evidence from the literature related to the presence of central sensitization (CS) in patients with OA.Electronic databases PubMed and Web of Science were searched to identify relevant articles using pre-defined keywords regarding CS and OA. Full-text clinical reports addressing studies of CS in human adults with chronic complaints due to osteoarthritis were included and screened for methodological quality by two independent reviewers. From the…
SP0088 New drugs, but still comorbidity
2017
As the population ages the simultaneous presence of multiple pathological conditions in the form of comorbidity and multimorbidity is more a rule than an exception. Comorbidity is reported in 35 to 80% of all ill people (Taylor et al. 2010). Comorbidity and multimorbidity are challenging researchers, clinicians and policy makers as these persons require more frequent appointments and hospitalizations and are at a greater risk for drug interactions, disability and mortality (Slater 2011). Although numerous chronic disease prevention strategies and treatment guidelines have been developed, they mainly address single conditions and ignore the presence of co-existing conditions (van der Noyen 2…
Resistance training for chronic low back pain in the elderly: A systematic review
2021
Chronic low back pain is a musculoskeletal pathology with a considerably high prevalence in the elderly. This condition increases disability and negatively affects the quality of life. Muscular resistance training is being used as a cornerstone in interventions for elder people due to the numerous benefits associated with physical and functional health. For this reason, the purpose of this study was to systematically review the literature on the main characteristics of resistance training programs in the elder population with chronic low back pain. A literature search in five databases (PubMed, Scopus, Web of Science, Sports Discuss, and Cochrane Library) was carried out. Inclusion-exclusio…