Search results for "Pain"
showing 10 items of 6371 documents
The impact of head and neck radiotherapy on the dentine-enamel junction: a systematic review
2019
Background Radiotherapy is widely used in contemporary head and neck cancer treatment protocols. The ability of head and neck radiotherapy (HNRT) to cause direct radiogenic destruction to the teeth is one of the most controversial topics in the field of oral oncology. Therefore, this systematic review aimed to investigate ionising radiation as an independent factor for physical and chemical changes on the dentine-enamel junction (DEJ), a pivotal dental topography for the onset and progression of radiation-related caries (RRC) and enamel delamination. Material and Methods Systematic searches were conducted on three databases: Scopus, MEDLINE (Via PubMed) and Embase (Elsevier). Laboratory stu…
Efficacy of different methods used for dry socket management: A systematic review.
2015
Document publicat també en castellà
The rodent tibia fracture model: A critical review and comparison with the complex regional pain syndrome literature
2018
Abstract Distal limb fracture is the most common cause of complex regional pain syndrome (CRPS), thus the rodent tibia fracture model (TFM) was developed to study CRPS pathogenesis. This comprehensive review summarizes the published TFM research and compares these experimental results with the CRPS literature. The TFM generated spontaneous and evoked pain behaviors, inflammatory symptoms (edema, warmth), and trophic changes (skin thickening, osteoporosis) resembling symptoms in early CRPS. Neuropeptides, inflammatory cytokines, and nerve growth factor (NGF) have been linked to pain behaviors, inflammation, and trophic changes in the TFM model and proliferating keratinocytes were identified …
A pyrroloquinazoline derivative with anti-inflammatory and analgesic activity by dual inhibition of cyclo-oxygenase-2 and 5-lipoxygenase
2002
Abstract In a previous study, we reported a new pyrroloquinazoline derivative, 3-(4′-acetoxy-3′,5′-dimethoxy)benzylidene-1,2-dihydropyrrolo[2,1- b ]quinazoline-9-one (PQ), which inhibited human purified 5-lipoxygenase activity and prostaglandin E 2 release in lipopolysaccharide-stimulated RAW 264.7 cells. In the present work, we show that PQ inhibits cyclo-oxygenase-2 activity in intact cell assays (human monocytes) and purified enzyme preparations (ovine isoenzymes) without affecting cyclo-oxygenase-1 activity. This behaviour was confirmed in vivo by using the zymosan-injected mouse air pouch model, where PQ caused a marked reduction in cell migration and leukotriene B 4 levels at 4 h, as …
Teaching the placement of posterior resin-based composite restorations in Spanish dental schools
2012
Objectives: In an area of esthetic dentistry such as posterior composites, in which new materials and techniques are being devolved continuously, it is important to confirm that dental students have a clear understanding of the basic principles of clinical application of this knowledge. Considering that the preparation of dental graduates in Spain may be of interest to competent dental authorities and employers with whom they can work worldwide, this study investigated the teaching of posterior composite restorations in Spanish dental schools. Study design: In late 2009/ early 2010, a questionnaire seeking information on the teaching of posterior composites was emailed to the professor resp…
C5a complement and cytokine signaling mediate the pronociceptive effects of complex regional pain syndrome patient IgM in fracture mice.
2020
It has been proposed that complex regional pain syndrome (CRPS) is a posttraumatic autoimmune disease. Previously, we observed that B cells contribute to CRPS-like changes in a mouse tibia fracture model, and that early (12 months duration) CRPS patient IgM antibodies have pronociceptive effects in the skin and spinal cord of muMT fracture mice lacking B cells. The current study evaluated the pronociceptive effects of intraplantar or intrathecal injections of early CRPS IgM (5 µg) in muMT fracture mice. Skin and lumbar spinal cord were collected for immunohistochemistry and polymerase chain reaction analyses. Wild-type mice exhibited postfracture increases in complement component C5a and it…
Neural Mechanisms of Acceptance and Commitment Therapy for Chronic Pain: A Network-Based fMRI Approach
2021
AbstractOver 100 million Americans suffer from chronic pain (CP), which causes more disability than any other medical condition in the U.S. at a cost of $560-$635 billion per year (IOM, 2011). Opioid analgesics are frequently used to treat CP. However, long term use of opioids can cause brain changes such as opioid-induced hyperalgesia that, over time, increase pain sensation. Also, opioids fail to treat complex psychological factors that worsen pain-related disability, including beliefs about and emotional responses to pain. Cognitive behavioral therapy (CBT) can be efficacious for CP. However, CBT generally does not focus on important factors needed for long-term functional improvement, i…
Understanding the relationship between subjective health complaints and satisfaction with life for people in prevocational training in Norway
2021
Background and aim: In Norway, a large part of the population is dependent on disability benefits. The main reasons for this are related to long-term musculoskeletal pain and psychological complaints. Prevocational rehabilitation, aimed at increasing participation in working life, targets people in need of a sheltered vocational environment. This group has been found to report a very high level of health complaints. Therefore, a better understanding of the psychological mechanisms affecting satisfaction with life for people who experience subjective health complaints could be important for tailoring more optimal vocational rehabilitation initiatives for these individuals. This study aimed t…
Lihavuuden biopoliittinen haltuunotto : Suomen Lääkärilehden tekstit lihavuudesta vuosilta 1995-2008 medikalisoituneessa kulttuurissa
2009
Tutkielmassa käsitellään Suomen Lääkärilehden (n=47) kirjoittelua lihavuudesta ja ylipainosta vuosien 1995-2008 väliseltä ajalta. Varsinainen tutkimustehtävä on kahtalainen: tutkimuksessa keskitytään siihen millaisia hegemonisia diskursseja terveysalan asiantuntijat tuottavat Suomen Lääkärilehden lihavuuspuheessa. Toisekseen tarkastellaan, miten esiin nostetuilla hegemonisilla diskursseilla pyritään kontrolloimaan ihmisten elämänkäytäntöjä. Huomio kohdistuu erityisesti lihavuuden ja ruumiillisuuksien hallinnan käytäntöihin, joilla terveysammattilaiset pyrkivät vaikuttamaan ihmisten tapoihin orientoitua elämäänsä. Tutkimuksen teoreettis-metodologiset ratkaisut pohjautuivat sosiaalisen konstr…
Atención a la salud mental en adolescentes en conflicto con la ley: Una revisión comparativa de Brasil y España
2021
Se realizó un estudio comparativo descriptivo de las políticas de atención de salud mental dirigidas a adolescentes en conflicto con la ley en Brasil y España. Se realizaron búsquedas en las bases de datos Google Académico, Medline y Scopus utilizando dos estrategias de búsqueda integral para identificar y sintetizar la literatura. Se identificaron tres categorías principales que permiten definir y analizar las políticas de atención a la salud mental dirigidas a adolescentes en conflicto con la ley en Brasil y España: 1) modelos de atención a la salud y salud mental, 2) redes de atención a la salud mental infanto-juvenil, y 3) atención de salud mental a adolescentes en conflicto con la ley.…