Search results for "Pain"
showing 10 items of 6371 documents
Synthesis and Molecular Modeling Studies of Derivatives of a Highly Potent Peptidomimetic Vinyl Ester as Falcipain-2 Inhibitors
2012
Herein we report the synthesis of a set of constrained peptidomimetics endowed with an electrophilic vinyl ester warhead and structurally related to a previously identified lead compound, a potent and irreversible inhibitor of falcipain-2 (FP-2). FP-2 is the main hemoglobinase of the malaria parasite P. falciparum. The new compounds were evaluated for their inhibition against FP-2, and the results were rationalized on the basis of docking experiments. These studies underscore the pivotal role of both the ester function at the P1' site and the trifluoromethyl group of the P3 side chain in determining the correct orientation of the Michael acceptor warhead in the catalytic site, and as a cons…
Total Pain and Illness Acceptance in Pelvic Cancer Patients: Exploring Self-Efficacy and Stress in a Moderated Mediation Model.
2022
Cancer patients experience pain not only in its physical dimension, but also in a broader context that includes psychological, social, and spiritual aspects due to a higher level of anxiety and stress. The present prospective, longitudinal study examined the relationship between total pain and illness acceptance among pelvic cancer patients, taking into consideration the moderated mediation effects of self-efficacy and stress. The study involved a sample of pelvic cancer patients receiving radiotherapy treatment. Assessments were completed at T1 (before radiotherapy), T2 (after 3–4 weeks), and T3 (after radiotherapy) to assess the psychosocial dynamics of illness acceptance (N = 267). The m…
Perhekeskuksen eri palveluiden merkitys ja vastaavuus lapsiperheiden muuttuviin tarpeisiin ja toiveisiin : tapaustutkimus perhekeskus Tourutuvan palv…
2000
Kilot kuriin vedellä ja näkkileivällä : 9-luokkalaisten tyttöjen käsityksiä ja kokemuksia laihduttamisesta ja painonhallinnasta
2003
Isolation of Four Lytic Phages Infecting Klebsiella pneumoniae K22 Clinical Isolates from Spain
2020
This article belongs to the Special Issue Bacteriophage—Molecular Studies.
Plant Specialized Metabolites in Hazelnut (Corylus avellana) Kernel and Byproducts: An Update on Chemistry, Biological Activity, and Analytical Aspec…
2019
Abstract Corylus avellana (hazelnut) is one of the most popular tree nuts on a worldwide basis. The main products of C. avellana are kernels, a nutritious food, with a high content of healthy lipids, contained in a hard shell. In recent years, along with the ongoing research carried out on hazelnut kernels, a growing interest has been addressed to the hazelnut byproducts including hazelnut skin, hazelnut hard shell, and hazelnut green leafy cover as well as hazelnut tree leaf. These byproducts deriving from the roasting, cracking, shelling/hulling, and harvesting processes have been found as a source of “phytochemicals” with biological activity. The aim of this review is to provide a compre…
Calpains promote α2β1 integrin turnover in non-recycling integrin pathway.
2012
Collagen receptor integrins recycle between the plasma membrane and endosomes and facilitate formation and turnover of focal adhesions. In contrast, clustering of α2β1 integrin with antibodies or the human pathogen echovirus 1 (EV1) causes redistribution of α2 integrin to perinuclear multivesicular bodies, α2-MVBs. We show here that the internalized clustered α2 integrin remains in α2-MVBs and is not recycled back to the plasma membrane. Instead, receptor clustering and internalization lead to an accelerated down-regulation of α2β1 integrin compared to the slow turnover of unclustered α2 integrin. EV1 infection or integrin degradation is not associated with proteasomal or autophagosomal pro…
MATERIALS AND ARTISTIC TECHNIQUES OF THE FLEMISH WOODEN ALTAR FROM DEPOSITS OF ABATELLIS PALACE MUSEUM (PALERMO, ITALY)
2022
In the frame of the restoration intervention on a 16th century wooden altar performed by the experts of the Gallery of Art for the Sicilian Region ‘Palazzo Abatellis’, a deep scientific investigation of the artwork has been made by a scientific team in order to individuate the constitutive materials and techniques. The outcomes from the multi-analytical analyses supported the scheduling and monitoring of the conservation treatments and revealed the pictorial materials and underdrawing techniques typical of the artistic production for this typology of work of art widespread between the 15th and 16th centuries in central and northern Europe.
Course and Predictors of Pain and Physical Functioning in Patients with Hip Osteoarthritis: Systematic Review and Meta-Analysis
2016
Objective: To systematically summarize the literature on: (i) the course of pain and physical functioning; and (ii) predictors of deterioration of pain and physical functioning in patients with osteoarthritis of the hip. Methods: A literature search was conducted in PubMed, CINAHL, Embase, PsychINFO and SPORTDiscus up to July 2015. Meta-analyses and qualitative data syntheses were performed. Results: Eleven of the 15 included studies were of high quality. With regard to the course of pain and physical functioning, high heterogeneity was found across studies (I2 >71%) and within study populations (reflected by large standard deviations of change scores). Therefore, the course of pain and phy…
L’affresco con la Virgo lactans “in maestà” e la Trinità tricefala: un’opera castigliana?
2023
Nel saggio si approfondisce la lettura iconografica di un affresco tardo-gotico dell'ultimo quarto del XV secolo conservato nella chiesa di Santa Maria la Porta di Geraci Siculo (PA). La Madonna che allatta il Bambino, il tipo di trono architettonico in cui è posta e la presenza della rara iconografia della Trinità tricefala suggeriscono una matrice iberica, probabilmente castigliana The essay explores the iconographic interpretation of a late Gothic fresco from the last quarter of the 15th century preserved in the church of Santa Maria la Porta in Geraci Siculo (PA). The Madonna suckling the Child, the type of architectural throne on which she is placed and the presence of the rare iconogr…