Search results for "Paired-pulse"

showing 4 items of 4 documents

Inter- and intra-individual variability of paired-pulse curves with transcranial magnetic stimulation (TMS).

2002

Objectives: Previous studies have evaluated the variability of motor thresholds (MTs) and amplitude of motor-evoked potentials (MEPs) to transcranial magnetic stimulation (TMS) within and across individuals. Here we evaluate the reproducibility and inter-hemispheric variability of measures of cortical excitability using the 'conventional' paired-pulse (PP) TMS technique. Methods: We studied PP curves of the left and right hemisphere in 10 healthy subjects on two separate days 2 weeks apart. The inter-stimulus intervals studied were 1, 3, 6, 8, 10 and 12 ms with the conditioning stimulus being 80% of the resting MT, and a single test stimulus producing MEPs of approximately 0.8 mV peak-to-pe…

AdultMalemedicine.medical_specialtyTime Factorsmedicine.medical_treatmentNeurophysiologyAudiologyStimulus (physiology)Lateralization of brain functionElectromagnetic FieldsPhysiology (medical)medicineHumansHealthy subjectsDominance CerebralObserver VariationReproducibilityMotor CortexMotor controlReproducibility of ResultsCortical excitabilityPaired-pulseNeurophysiologyMiddle AgedEvoked Potentials MotorSensory SystemsElectric StimulationTranscranial magnetic stimulationmedicine.anatomical_structureNeurologySensory ThresholdsLateralityFemaleNeurology (clinical)PsychologyNeuroscienceTranscranial magnetic stimulationMotor cortexClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
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Long-term effects on motor cortical excitability induced by repeated muscle vibration during contraction in healthy subjects

2008

article i nfo Objective: The effects of a novel repeated muscle vibration intervention (rMV; 100 Hz, 90 min over 3 consecutive days) on corticomotor excitability were studied in healthy subjects. Methods: rMV was applied over the flexor carpi radialis (FCR) during voluntary contraction (experiment 1), during relaxation and during contraction without vibration (experiment 2). Focal transcranial magnetic stimulation (TMS) was applied before rMV and one hour, and one, two and three weeks after the last muscle vibration intervention. At each of these time points, we assessed the motor map area and volume in the FCR, extensor digitorum communis (EDC) and abductor digiti minimi (ADM). Short-inter…

MaleMotor disorderpaired-pulse tmsTime FactorsContraction (grammar)H-Reflex; Analysis of Variance; Humans; Electromyography; Neural Inhibition; Electric Stimulation; Muscle Skeletal; Motor Cortex; Brain Mapping; Vibration; Evoked Potentials Motor; Adult; Middle Aged; Muscle Contraction; Transcranial Magnetic Stimulation; Time Factors; Female; Malemedicine.medical_treatmentH-ReflextmsEvoked PotentialsBrain Mappingcortical plasticitySkeletalMiddle AgedTranscranial Magnetic Stimulationmedicine.anatomical_structureMotorNeurologyAnesthesiaMuscleFemaleSettore MED/26 - NeurologiaPrimary motor cortexmedicine.symptomPsychologyMuscle ContractionMotor cortexMuscle contractionAdultintracortical inhibitionVibrationNOmuscle vibrationmotor cortexNeuroplasticitymedicineHumansMuscle SkeletalAnalysis of VarianceneurorehabilitationElectromyographytms; muscle vibration; paired-pulse tms; neurorehabilitation; motor cortex; cortical plasticity; intracortical inhibitionNeural InhibitionEvoked Potentials Motormedicine.diseaseElectric Stimulationbody regionsTranscranial magnetic stimulationNeurology (clinical)NeuroscienceExtensor Digitorum Communis
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Motor intracortical inhibition in PD: L-DOPA modulation of high-frequency rTMS effects

2007

Dopaminergic drugs and deep brain stimulation restore cortical inhibition in Parkinson disease (PD) patients. High-frequency rTMS was also found to increase cortical inhibition in PD but its therapeutic effect is still controversial. Here we hypothesize that, if dopaminergic drugs reverse to normal cortical excitability in M1, the effect of high-frequency (hf)-rTMS in PD patients could depend on whether they are in a medicated or unmedicated state. The present study aims to explore the lasting effects of sub-threshold hf rTMS trains over M1 on cortical inhibition in patients with "on" and without "off" L-DOPA treatment. Fourteen PD patients were examined twice while "on" and "off" medicatio…

Malemedicine.medical_specialtyNeurologyDeep brain stimulationCORTICAL SILENT PERIODmedicine.medical_treatmentStimulationMotor ActivityInhibitory postsynaptic potentialPAIRED-PULSE INHIBITIONAntiparkinson AgentsLevodopaDegenerative diseaseEVOKED-POTENTIALSmedicineHumansCORTEX EXCITABILITYAgedAged 80 and overSUBTHALAMIC NUCLEUSPARKINSONS-DISEASE PATIENTSGeneral NeuroscienceDopaminergicMotor CortexNeural InhibitionParkinson DiseaseMiddle Agedmedicine.diseaseFACILITATIONCombined Modality TherapyTranscranial Magnetic StimulationTranscranial magnetic stimulationBRAIN-STIMULATIONmedicine.anatomical_structureSettore MED/26 - NeurologiaFemaleREPETITIVE TMSPsychologyNeuroscienceMotor cortexExperimental Brain Research
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Identification of Synaptic Integration Mode in CA3 Pyramidal Neuron Model

2019

International audience; A morphologically realistic and anisotropic model of CA3 pyramidal neuron was developed to determine the synaptic integration modes the neuron is able to perform. Linearity and nonlinearity were identified in different synaptic locations with varying active mechanisms such as the presence of ionic channels in the dendritic arbor and the types of receptors in the synapse. Quantification of synaptic integration was performed using paired-pulse stimulation protocol and subthreshold input/output (sI/O) transformation. Results show that the mode of synaptic integration is location-dependent while the linearity or nonlinearity in the integration is mainly influenced by the…

MorphologyShaftsionic channelsResistancereceptorstwo-layer networksynaptic integration modesimple CA3 pyramidal neuronSynapselinear integrationdendritic arbormedicinesynaptic locationsCA3 pyramidal neuron model[SDV.IB] Life Sciences [q-bio]/BioengineeringNeuronsbiomembrane transportcomputational powerPhysicssubthreshold input-output transformationSynaptic integrationSubthreshold conductionmorphologically realistic modelMode (statistics)Linearitypaired-pulse stimulation protocolactive channelsanisotropic modelNonlinear systemmedicine.anatomical_structurenervous systemsublinear integrationCa3 pyramidal neuronbioelectric phenomena[SDV.IB]Life Sciences [q-bio]/BioengineeringAction potentialsNeuronneurophysiologysupralinear integrationNeuroscienceNeckProtocols2019 9th International IEEE/EMBS Conference on Neural Engineering (NER)
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