Search results for "Pandanaceae"

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Phosphorylation and activation of endothelial nitric oxide synthase by red fruit (Pandanus conoideus Lam) oil and its fractions

2020

Abstract: Ethnopharmacological relevance Red fruit (Pandanus conoideus Lam) oil (RFO) is utilized by inhabitants of the Papua Island to treat diseases such as infections, cancer, and cardiovascular disease, but the mechanism of action is unknown. Aim of the study We have recently shown that RFO stimulates nitric oxide (NO) production in endothelial cells. The present study was conducted to investigate the molecular mechanism of endothelial NO synthase (eNOS) activation by RFO. Materials and methods NO production by endothelial cells was determined with electron paramagnetic resonance. The vascular function of isolated mouse aorta was examined using a wire myograph system. Phosphorylation of…

Nitric Oxide Synthase Type IIIVasodilator AgentsAorta ThoracicVasodilationPharmacologyNitric OxideCell LineNitric oxide03 medical and health scienceschemistry.chemical_compound0302 clinical medicineEnosDrug DiscoverymedicineAnimalsHumansPlant OilsPhosphorylationPandanaceaeProtein kinase BPI3K/AKT/mTOR pathway030304 developmental biologyPharmacology0303 health sciencesbiologyEndothelial CellsAMPKbiology.organism_classificationMice Inbred C57BLchemistryMechanism of actionFruit030220 oncology & carcinogenesisPhosphorylationmedicine.symptomJournal of Ethnopharmacology

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