Search results for "Papers"
showing 10 items of 345 documents
1-Benzyl-1H-benzotriazole 3-oxide-1-hy-droxy-1H-benzotriazole (1/1).
2012
In the title compound, C6H5N3O·C13H11N3O, the benzotriazole ring system in the 1-benzyl-1H-benzotriazole 3-oxide (A) molecule is close to being planar (r.m.s. deviation = 0.011 Å); its mean plane forms a dihedral angle of 67.56 (7)° with that of the attached phenyl ring. The benzotriazole ring system in the 1-hydroxybenzotriazole (B) molecule is also close to being planar (r.m.s. deviation = 0.010 Å). In the crystal, weak C—H...O and C—H...π interactions are present. TheAandBmolecules are linked by an O—H...N hydrogen bond.
4-(4-Fluorophenyl)-2-methyl-3-(1-oxy-4-pyridyl)isoxazol-5(2H)-one
2008
The crystal structure of the title compound, C15H11FN2O3, was determined as part of a study on the biological activity of isoxazolone derivatives as p38 mitogen-activated protein kinase (MAPK) inhibitors. The dihedral angles between rings are isoxazole/benzene = 55.0 (3)°, isoxazole/pyridine = 33.8 (2)° and benzene/pyridine = 58.1 (2)°.
EVpedia: a community web portal for extracellular vesicles research
2014
Abstract Motivation: Extracellular vesicles (EVs) are spherical bilayered proteolipids, harboring various bioactive molecules. Due to the complexity of the vesicular nomenclatures and components, online searches for EV-related publications and vesicular components are currently challenging. Results: We present an improved version of EVpedia, a public database for EVs research. This community web portal contains a database of publications and vesicular components, identification of orthologous vesicular components, bioinformatic tools and a personalized function. EVpedia includes 6879 publications, 172 080 vesicular components from 263 high-throughput datasets, and has been accessed more tha…
Triphenyl[(4-phenylbenzoyl)methyl]phosphonium trifluoromethanesulfonate
2010
In the cation of the title compound, C32H26OP+·CF3O3S−, the dihedral angle between the benzene rings of the biphenyl group is 42.37 (8)°. In the crystal, the cations and anions interact through intermolecular C—H...O hydrogen bonds, forming chains parallel to the b axis. These chains are further linked by C—H...π stacking interactions into layers parallel to the bc plane.
Effectiveness of an Interventional Program to Improve Blood Pressure Control in Hypertensive Patients at High Risk for Developing Heart Failure: HERO…
2010
J Clin Hypertens (Greenwich). The Efectividad de un Programa de Intervencion en el Control de la Presion Arterial de los Hipertensos en Riesgo de Desarrollar Insuficiencia Cardiaca (HEROIC) study was designed to assess whether an educational program for primary care physicians could improve blood pressure (BP) control in hypertensive patients at high risk for developing heart failure. The program contained a combination of educational training (live group sessions or online training) and information feedback. Two hundred twenty-six physicians completed the program and provided valid data in 2489 patients before and 2168 after 1 year. There was a small but significant reduction of −1.1 mm Hg…
"A 304-year experiment which worked some but not all of the time" : Britain and British identities in three English, Scottish and Welsh newspapers in…
2014
Britannia ja sen eri maat ovat unionin pitkän historian kuluessa kohdanneet lukuisia muutoksia ja haasteita. Viimeaikaisimmat näistä haasteista ovat liittyneet esimerkiksi siihen miten unionia ja sen maita hallitaan: vuonna 1997 unionin valtaa hajautettiin sisäisille paikallishallinnoille, jonka jälkeen muun muassa Wales on saavuttanut laajemmat oikeudet omien lakien säätämiseen ja Skotlanti on syksyllä 2014 äänestämässä mahdollisesta itsenäisyydestä. Tällaiset kehitykset herättävät kysymyksiä siitä, miten unioni nykyään toimii, kuinka vahvasti sen eri maat ovat sidoksissa toisiinsa, ja miltä sen tulevaisuus näyttää. Tämän tutkielman tarkoitus on tarkastella sitä, miten Britanniaa ja britti…
Mnemoniskie paņēmieni drukātajos sludinājumos
2021
Mūsdienās reklāmas tiek lietotas, lai ietekmētu patērētāju lēmumu pieņemšanu, un tajās tiek lietotas dažādas reklāmas metodes. Līdztekus citām metodēm, reklāmās tiek lietoti arī mnemoniskie paņēmieni, kas palīdz labāk atcerēties reklāmas tekstus. Šī darba mērķis ir izpētīt mnemoniskos paņēmienus un analizēt mnemonisko paņēmienu biežumu Lielbritānijas laikrakstos, izmantojot kvalitatīvās un kvantitatīvās pētījumu metodes - diskursa un biežuma analīzi. Kopumā tika analizēti četrpadsmit laikraksti, lai tajos atrastu mnemonisks ierīces. Šī pētījuma rezultāti apstiprina, ka 61 no 247 laikrakstu reklāmām ir mnemoniskie paņēmieni, visos 14 Lielbritānijas laikrakstos katrā laikraksta numurā ir vism…
Drug Screening Boosted by Hyperpolarized Long-Lived States in NMR
2014
International audience; : Transverse and longitudinal relaxation times (T1ρ and T1 ) have been widely exploited in NMR to probe the binding of ligands and putative drugs to target proteins. We have shown recently that long-lived states (LLS) can be more sensitive to ligand binding. LLS can be excited if the ligand comprises at least two coupled spins. Herein we broaden the scope of ligand screening by LLS to arbitrary ligands by covalent attachment of a functional group, which comprises a pair of coupled protons that are isolated from neighboring magnetic nuclei. The resulting functionalized ligands have longitudinal relaxation times T1 ((1) H) that are sufficiently long to allow the powerf…
Orbital Decomposition of the Carbon Chemical Shielding Tensor in Gold(I) N-Heterocyclic Carbene Complexes.
2020
The good performance of N‐heterocyclic carbenes (NHCs), in terms of versatility and selectivity, has called the attention of experimentalists and theoreticians attempting to understand their electronic properties. Analyses of the Au(I)–C bond in [(NHC)AuL]+/0 (L stands for a neutral or negatively charged ligand), through the Dewar–Chatt–Duncanson model and the charge displacement function, have revealed that NHC is not purely a σ‐donor but may have a significant π‐acceptor character. It turns out, however, that only the σ‐donation bonding component strongly correlates with one specific component of the chemical shielding tensor. Here, in extension to earlier works, a current density analysi…
Generation of CD8+T cells expressing two additional T-cell receptors (TETARs) for personalised melanoma therapy
2015
Adoptive T-cell therapy of cancer often fails due to the tumor cells' immune escape mechanisms, like antigen loss or down-regulation. To anticipate immune escape by loss of a single antigen, it would be advantageous to equip T cells with multiple specificities. To study the possible interference of 2 T-cell receptors (TCRs) in one cell, and to examine how to counteract competing effects, we generated TETARs, CD8(+) T cells expressing two additional T-cell receptors by simultaneous transient transfection with 2 TCRs using RNA electroporation. The TETARs were equipped with one TCR specific for the common melanoma antigen gp100 and one TCR recognizing a patient-specific, individual mutation of…