Search results for "Parametric statistics"
showing 10 items of 354 documents
Permutation Test (PT) and Tolerated Difference Test (TDT): Two new, robust and powerful nonparametric tests for statistical comparison of dissolution…
2013
The most popular way of comparing oral solid forms of drug formulations from different batches or manufacturers is through dissolution profile comparison. Usually, a similarity factor known as (f2) is employed; However, the level of confidence associated with this method is uncertain and its statistical power is low. In addition, f2 lacks the flexibility needed to perform in special scenarios. In this study two new statistical tests based on nonparametrical Permutation Test theory are described, the Permutation Test (PT), which is very restrictive to confer similarity, and the Tolerated Difference Test (TDT), which has flexible restrictedness to confer similarity, are described and compared…
Efficient Computation of Multiscale Entropy over Short Biomedical Time Series Based on Linear State-Space Models
2017
The most common approach to assess the dynamical complexity of a time series across multiple temporal scales makes use of the multiscale entropy (MSE) and refined MSE (RMSE) measures. In spite of their popularity, MSE and RMSE lack an analytical framework allowing their calculation for known dynamic processes and cannot be reliably computed over short time series. To overcome these limitations, we propose a method to assess RMSE for autoregressive (AR) stochastic processes. The method makes use of linear state-space (SS) models to provide the multiscale parametric representation of an AR process observed at different time scales and exploits the SS parameters to quantify analytically the co…
Multivariate nonparametric tests in a randomized complete block design
2003
AbstractIn this paper multivariate extensions of the Friedman and Page tests for the comparison of several treatments are introduced. Related unadjusted and adjusted treatment effect estimates for the multivariate response variable are also found and their properties discussed. The test statistics and estimates are analogous to the traditional univariate methods. In test constructions, the univariate ranks are replaced by multivariate spatial ranks (J. Nonparam. Statist. 5 (1995) 201). Asymptotic theory is developed to provide approximations for the limiting distributions of the test statistics and estimates. Limiting efficiencies of the tests and treatment effect estimates are found in the…
Influence Functions and Efficiencies of k-Step Hettmansperger–Randles Estimators for Multivariate Location and Regression
2016
In Hettmansperger and Randles (Biometrika 89:851–860, 2002) spatial sign vectors were used to derive simultaneous estimators of multivariate location and shape. Oja (Multivariate nonparametric methods with R. Springer, New York, 2010) proposed a similar approach for the multivariate linear regression case. These estimators are highly robust and have under general assumptions a joint limiting multinormal distribution. The estimates are easy to compute using fixed-point algorithms. There are however no exact proofs for the convergence of these algorithms. The existence and uniqueness of the solutions also still remain unproven although we believe that they hold under general conditions. To ci…
MuTE: a new matlab toolbox for estimating the multivariate transfer entropy in physiological variability series
2014
We present a new time series analysis toolbox, developed in Matlab, for the estimation of the Transfer entropy (TE) between time series taken from a multivariate dataset. The main feature of the toolbox is its fully multivariate implementation, that is made possible by the design of an approach for the non-uniform embedding (NUE) of the observed time series. The toolbox is equipped with parametric (linear) and non-parametric (based on binning or nearest neighbors) entropy estimators. All these estimators, implemented using the NUE approach in comparison with the classical approach based on uniform embedding, are tested on RR interval, systolic pressure and respiration variability series mea…
Measuring Connectivity in Linear Multivariate Processes: Definitions, Interpretation, and Practical Analysis
2011
This tutorial paper introduces a common framework for the evaluation of widely used frequency-domain measures of coupling (coherence, partial coherence) and causality (directed coherence, partial directed coherence) from the parametric representation of linear multivariate (MV) processes. After providing a comprehensive time-domain definition of the various forms of connectivity observed in MV processes, we particularize them to MV autoregressive (MVAR) processes and derive the corresponding frequency-domain measures. Then, we discuss the theoretical interpretation of these MVAR-based connectivity measures, showing that each of them reflects a specific time-domain connectivity definition an…
Multivariate and Multiscale Complexity of Long-Range Correlated Cardiovascular and Respiratory Variability Series
2020
Assessing the dynamical complexity of biological time series represents an important topic with potential applications ranging from the characterization of physiological states and pathological conditions to the calculation of diagnostic parameters. In particular, cardiovascular time series exhibit a variability produced by different physiological control mechanisms coupled with each other, which take into account several variables and operate across multiple time scales that result in the coexistence of short term dynamics and long-range correlations. The most widely employed technique to evaluate the dynamical complexity of a time series at different time scales, the so-called multiscale …
Rank scores tests of multivariate independence
2004
New rank scores test statistics are proposed for testing whether two random vectors are independent. The tests are asymptotically distribution-free for elliptically symmetric marginal distributions. Recently, Gieser and Randles (1997), Taskinen, Kankainen and Oja (2003) and Taskinen, Oja and Randles (2005) introduced and discussed different multivariate extensions of the quadrant test, Kendall's tau and Spearman's rho statistics. In this paper, standardized multivariate spatial signs and the (univariate) ranks of the Mahalanobis-type distances of the observations from the origin are combined to construct ranks cores tests of independence. The limiting distributions of the test statistics ar…
Non-Parametric Rank Statistics for Spectral Power and Coherence
2019
AbstractDespite advances in multivariate spectral analysis of neural signals, the statistical inference of measures such as spectral power and coherence in practical and real-life scenarios remains a challenge. The non-normal distribution of the neural signals and presence of artefactual components make it difficult to use the parametric methods for robust estimation of measures or to infer the presence of specific spectral components above the chance level. Furthermore, the bias of the coherence measures and their complex statistical distributions are impediments in robust statistical comparisons between 2 different levels of coherence. Non-parametric methods based on the median of auto-/c…
Vector Autoregressive Fractionally Integrated Models to Assess Multiscale Complexity in Cardiovascular and Respiratory Time Series
2020
Cardiovascular variability is the result of the activity of several physiological control mechanisms, which involve different variables and operate across multiple time scales encompassing short term dynamics and long range correlations. This study presents a new approach to assess the multiscale complexity of multivariate time series, based on linear parametric models incorporating autoregressive coefficients and fractional integration. The approach extends to the multivariate case recent works introducing a linear parametric representation of multiscale entropy, and is exploited to assess the complexity of cardiovascular and respiratory time series in healthy subjects studied during postu…