Search results for "Parkinsonin tauti"
showing 3 items of 13 documents
Fragment‐ and Negative Image‐Based Screening of Phosphodiesterase 10A Inhibitors
2019
A novel virtual screening methodology called fragment‐ and negative image‐based (F‐NiB) screening is introduced and tested experimentally using phosphodiesterase 10A (PDE10A) as a case study. Potent PDE10A‐specific small‐molecule inhibitors are actively sought after for their antipsychotic and neuroprotective effects. The F‐NiB combines features from both fragment‐based drug discovery and negative image‐based (NIB) screening methodologies to facilitate rational drug discovery. The selected structural parts of protein‐bound ligand(s) are seamlessly combined with the negative image of the target's ligand‐binding cavity. This cavity‐ and fragment‐based hybrid model, namely its shape and electr…
Äskettäin diagnosoitujen Parkinsonin tautia sairastavien potilaiden kävely ja tasapaino : itsekoetun ja mitatun pystyasennon hallinnan ja kävelyn suo…
2013
Tämän tutkimuksen tarkoituksena oli selvittää äskettäin diagnosoidun Parkinson-potilaan itsearvioimaa pystyasennon hallintaa ja kävelyä suhteessa valittuihin kliinisten mittausten muuttujiin. Tutkimuksessa käytetyt mittarit olivat Bergin tasapainotesti (BBS), Timed Up and Go-testi (TUG), Four Square Stepping Test (FSST), GoodBalance ja GaitRite. Tutkittaville suoritettiin myös strukturoitu kysely tasapaino- ja kävelyrajoituksista. Tutkimus oli poikkileikkaustutkimus, jonka aineisto kerättiin Satakunnan sairaanhoitopiirin alueella vapaaehtoisista, vuoden 2007 kuluessa diagnosoitujen uusien potilaiden joukosta. Toimintakyvyn, toimintarajoitteiden ja terveyden kansainvälisen luokituksen (ICF, …
Heme Oxygenase-1 and Blood Bilirubin Are Gradually Activated by Oral D-Glyceric Acid
2022
It has been shown that small doses of oral D-glyceric acid (DGA) activate mitochondrial metabolism and reduce inflammation among 50–60-year-old healthy volunteers. The present results with the same small doses reveal that after a 4-day DGA regimen, a dose of DGA activated the HO-1 pathway acutely, while enhanced inflammatory status after the 4-day DGA regimen seemed to be able to downregulate the HO-1 pathway in non-acute measurement. Blood bilirubin was strongly upregulated towards the end of the altogether 21-day study period with positive associations towards improved inflammation and reduced blood triglycerides. After the 4-day DGA regimen, hepatic inflow of blood bilirubin with albumin…