Search results for "Patch"
showing 10 items of 337 documents
Testosterone and male mating success on the black grouse leks
1996
On black grouse (Tetrao tetrix) leks females prefer dominant, viable males that have managed to acquire relatively central territories. The immunocompetence hypothesis predicts that, because high levels of testosterone are costly to the immune system, male sexual traits that are controlled by testosterone are likely to serve as reliable indicators of male health. Indeed, testosterone concentrations of black grouse males were highly variable, and strongly correlated with male mating success. This is related to the fact that males with high testosterone levels had most central territories. However, the association of testostestorone level with male mating success was not solely related to cen…
Vibro-acoustocal behavior of composite structures with damping elements
2013
This work is on the subject of modelization of structures treated with passive damping elements. A generic "equivalent single layer" plate model using transverse shear warping functions is presented. Several methods to obtain these functions are described, allowing the implementation of classical models and others issued from the litterature. Two new methods for obtaining these functions are also presented.Several discretization methods adapted to the generic plate model are studied. Navier's procedure allows the testing of the quality of each model associated with a set of transverse shear warping functions. Rayleigh-Ritz method allows the study of the vibrational behavior of a rectangular…
Understanding Human Cancer Using Drosophila
2003
Recessive mutations of the Drosophila gene lethal(2)-tumorous imaginal discs (l(2)tid) cause neoplastic growth of the anlagen of the adult organs, the imaginal discs. Here we report that the three proteins encoded by this evolutionarily conserved gene, Tid50, Tid47, and Tid40, identified as members of the DnaJ cochaperone family, are destined for different cellular compartments, build complexes with many proteins in a developmental stage-specific manner, and are likely to be involved in different cellular processes. We show that the cytosolic Tid47 molecule is a novel component of the Hedgehog (Hh)-Patched (Ptc) signaling regulating cell/tissue polarity and spatial patterning during develop…
Salivary Testosterone and Cortisol as Biomarkers for the Diagnosis of Sarcopenia and Sarcopenic Obesity in Community-Dwelling Older Adults
2021
Nowadays, the appearance of sarcopenia (S) or sarcopenic obesity (SO) is related to aging. According to the criteria of the European Working Group on Sarcopenia in Older People (EWGSOP), the feasibility of using salivary cortisol and testosterone levels was analyzed as diagnostic biomarkers of S or SO. One hundred and ninety non-institutionalized people aged &ge
New Molecular Targets and Lifestyle Interventions to Delay Aging Sarcopenia
2014
The term sarcopenia was originally created to refer age-related loss of muscle mass with consequent loss of strength (Morley et al., 2001). There are now four international definitions of sarcopenia (Cruz-Jentoft et al., 2010; Muscaritoli et al., 2010; Morley et al., 2011). In essence they all agree, requiring a measure of walking capability [either low gait speed or a limited endurance (distance) in a 6-min walk], together with an appendicular lean mass of <2 SDs of a sex and ethnically corrected normal level for individuals 20–30 years old. Sarcopenia is a prevalent health problem among the elderly. On average, 5–13 and 11–50% of people aged 60−70 years and ≥80 years, respectively suffer …
Classification of the lesions observed in female genital schistosomiasis
2014
Author's version of an article in the journal: International Journal of Gynecology and Obstetrics. Also available from the publisher at: http://dx.doi.org/10.1016/j.ijgo.2014.07.014
Heat-induced action potential discharges in nociceptive primary sensory neurons of rats.
2009
Although several transducer molecules for noxious stimuli have been identified, little is known about the transformation of the resulting generator currents into action potentials (APs). Therefore we investigated the transformation process for stepped noxious heat stimuli (42-47 degrees C, 3-s duration) into membrane potential changes and subsequent AP discharges using the somata of acutely dissociated small dorsal root ganglion (DRG) neurons (diameteror=32.5 microm) of adult rats as a model for their own peripheral terminals. Three types of heat-induced membrane potential changes were differentiated: type 1, heat-induced AP discharges (approximately 37% of the neurons); type 2, heat-induce…
A circularly polarized wideband high gain patch antenna for wireless power transfer
2018
This article deals with a microstrip patch antenna working at 868 MHz, suitable for the radio frequency wireless power transfer and energy harvesting applications. The proposed monolithic antenna is compact, lightweight and it is printed on a thick substrate in order to maximize the total gain in the broadside direction. The antenna radiates at 868 MHz with a fractional impedance bandwidth of 5% and it shows a gain of 4.14 dB.
Coexpression of heat-evoked and capsaicin-evoked inward currents in acutely dissociated rat dorsal root ganglion neurons.
1997
Noxious heat is able to activate heat-sensitive nociceptors in the skin very rapidly, but little is known about the mechanisms by which heat is transduced. We used the whole-cell patch-clamp technique to study the effects of noxious heat and capsaicin on freshly dissociated rat dorsal root ganglion neurons in vitro. Using temperatures between 41 degrees C and 53 degrees C, 8 of 19 small neurons (phior = 30 microm) exhibited a heat-evoked inward current. All heat-sensitive neurons tested were also capsaicin-sensitive. Moreover, the heat response tended to be enhanced after capsaicin (360 +/- 150 pA versus 125 +/- 45 pA, P0.1, n = 7). Two of five heat-insensitive neurons were excited by capsa…
Nanoparticle formulations as recrystallization inhibitors in transdermal patches
2020
Abstract Drug crystallization in transdermal patches is still a major challenge, confronting the formulation development of topical drug delivery systems. Encapsulation of drugs into nanoparticles is proposed here as a promising tool for regulating drug crystallization in transdermal patches. The degree of recrystallization and transdermal permeation of ibuprofen and hydrocortisone loaded in polymeric and lipid nanoparticles from matrix-type transdermal patches were investigated. Ethyl cellulose (EC4), poly (lactide-co-glycolic acid) (PLGA) and polycaprolactone (PCL) were employed for polymeric nanoparticle preparations; while medium chain triglyceride (MCT) and witepsol were used for the p…