Search results for "Patent"
showing 10 items of 126 documents
Patented intelligence: Cloning human decision models for Industry 4.0
2018
Industry 4.0 is a trend related to smart factories, which are cyber-physical spaces populated and controlled by the collective intelligence for the autonomous and highly flexible manufacturing purposes. Artificial Intelligence (AI) embedded into various planning, production, and management processes in Industry 4.0 must take the initiative and responsibility for making necessary real-time decisions in many cases. In this paper, we suggest the Pi-Mind technology as a compromise between completely human-expert-driven decision-making and AI-driven decision-making. Pi-Mind enables capturing, cloning and patenting essential parameters of the decision models from a particular human expert making …
Innovation in cardiovascular disease in Europe with focus on arrhythmias: current status, opportunities, roadblocks, and the role of multiple stakeho…
2018
The European Heart Rhythm Association (EHRA) held an Innovation Forum in February 2016, to consider issues around innovation. The objective of the forum was to extend the innovation debate outside of the narrow world of arrhythmia specialists and cardiology in general, and seek input from all stakeholders including regulators, strategists, technologists, industry, academia, health providers, medical societies, payers, and patients. Innovation is indispensable for a continuing improvement in health care, preferably at higher efficacy and lower costs. It requires people who have been trained in a good scientific environment, high-quality research for achieving ground breaking inventions and t…
Monoclonal Antibodies, Bispecific Antibodies and Antibody-Drug Conjugates in Oncohematology
2020
Background: The therapeutic outcomes and the prognosis of patients with various hematologic malignancies are not always ideal with the current standard of care. Objective: The aim of this study is to analyze the results of the use of monoclonal antibodies, bispecific antibodies and antibody-drug conjugates for the therapy of malignant hemopathies. Methods: A mini-review was achieved using the articles published in Web of Science and PubMed between January 2017 and January 2020 and the new patents were made in this field. Results: Naked monoclonal antibodies have improved the therapeutic results obtained with standard of care, but they also have side effects and the use of some of them can …
Biopiracy of natural products and good bioprospecting practice
2016
Made available in DSpace on 2018-11-26T16:27:45Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-02-15 Deutsche Forschungsgemeinschaft Background: Biopiracy mainly focuses on the use of biological resources and/or knowledge of indigenous tribes or communities without allowing them to share the revenues generated out of economic exploitation or other non-monetary incentives associated with the resource/knowledge. Methods: Based on collaborations of scientists from five continents, we have created a communication platform to discuss not only scientific topics, but also more general issues with social relevance. This platform was termed 'PhytCancer -Phytotherapy to Fight Cancer' (www.phy…
Earthquake-resistant construction techniques in Italy between 1880 and 1910: alternatives to reinforced concrete
2017
The series of earthquakes that struck Italy between the late nineteenth century and the first decade of the twentieth century spurred a lively debate about earthquake-resistant buildings that, through the influence of foreign experience, resulted in specialised literature and competitions that gave rise to a series of interesting patents. Innovative construction solutions for seismic areas were largely developed after the earthquake that struck the cities of Messina and Reggio Calabria in 1908, alongside the parallel advances in reinforced concrete. New earthquake-resistant construction solutions were based on a reassessment of traditional construction methods that used bricks, timber or me…
La necesidad de flexibilizar la competencia judicial internacional exclusiva para determinar la validez de los derechos de patente
2015
La presente obra aborda el impacto de la competencia judicial exclusiva para determinar la validez de los derechos de patente sobre los litigios relativos a la infracción de estos derechos. Para llevar a cabo su análisis, hemos seguido la estructura descrita a continuación. 1) En primer lugar, hemos examinado los antecedentes históricos que llevaron a la inclusión de la norma de competencia judicial internacional exclusiva. Iniciar nuestra investigación retrotrayéndonos a los orígenes de la norma no es baladí, sino que obedece a la necesidad de comprender las razones que llevaron a su configuración tal y como la conocemos hoy. 2) En segundo lugar, se ha desarrollado un capítulo eminentement…
Litigación internacional en materia de patentes en Brasil: Análisis de la competencia judicial internacional y del arbitraje en materia de infracción…
2016
RESUMEN: El foco principal de la investigación y de la tesis consiste en el análisis de los litigios internacionales en materia de patentes en Brasil. Actualmente, Brasil es la séptima economía del mundo, con el producto interno bruto (PIB) de aproximadamente U$2.200 millones . El creciente desarrollo comercial brasileño exige normas jurídicas eficientes que auxilien ese proceso de crecimiento de la economía del país, y que no se ponga como un coste a más a las relaciones comerciales. El sistema brasileño de DIPr está conformado principalmente por normas de competencia judicial internacional y cooperación judicial (normas de naturaleza procesal), normas que indican el derecho aplicable y la…
Recurrent cerebral ischaemia in a pregnant woman with patent foramen ovale II° and thrombophilia.
2014
SummaryThis case report concerns a pregnant multipara (age: 27 years) in the 16th gestational week. She developed a sudden onset of paraesthesia in her left lower arm although injecting dalteparin 5000 IU once daily subcutaneously (s. c.) due to a heterozygous factor V Leiden mutation and a prior miscarriage in the first pregnancy and preeclampsia in her third pregnancy. After the miscarriage she delivered two healthy children under prophylactic anticoagulation with low molecular weight heparin (LMWH). Now via magnetic resonance imaging (MRI) she was diagnosed as having multiple cerebral ischaemic lesions. Further workup revealed the presence of a patent foramen ovale (PFO) II° but no venou…
Mutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm/aortic dissection and patent ductus arteriosus
2006
We have recently described two kindreds presenting thoracic aortic aneurysm and/or aortic dissection ( TAAD) and patent ductus arteriosus (PDA)(1,2) and mapped the disease locus to 16p12.2-p13.13 (ref. 3). We now demonstrate that the disease is caused by mutations in the MYH11 gene affecting the C-terminal coiled-coil region of the smooth muscle myosin heavy chain, a specific contractile protein of smooth muscle cells (SMC). All individuals bearing the heterozygous mutations, even if asymptomatic, showed marked aortic stiffness. Examination of pathological aortas showed large areas of medial degeneration with very low SMC content. Abnormal immunological recognition of SM-MHC and the colocal…
Transient hepatic nodular lesions associated with patent ductus venosus in preterm infants.
2010
We report on two cases of low-birth-weight preterm infants with patent ductus venosus associated with hepatic hypoechoic lesions of the fourth segment in an otherwise normal liver. Although tumorlike hepatic lesions have been previously reported in association with portosystemic shunts in children and adults, they were never described in preterm infants during physiological patency of ductus venosus. In our patients, hepatic lesions disappeared shortly after the spontaneous ductus closure. Physiopathologic interactions are discussed regarding altered portal blood supply caused by ductus venosus shunt.