Search results for "Pathology and Forensic Medicine"

Using the fibre structure of paper to determine authenticity of the documents: analysis of transmitted light images of stamps and banknotes.

2014

A novel method is presented for distinguishing postal stamp forgeries and counterfeit banknotes from genuine samples. The method is based on analyzing differences in paper fibre networks. The main tool is a curvelet-based algorithm for measuring overall fibre orientation distribution and quantifying anisotropy. Using a couple of more appropriate parameters makes it possible to distinguish forgeries from genuine originals as concentrated point clouds in two- or three-dimensional parameter space.

GHB related acids are useful in routine casework of suspected GHB intoxication cases

2021

Abstract GHB related acids (3,4-dihydroxy butyric acid, 2,4-dihydroxy butyric acid and glycolic acid) are produced through oxidative GHB metabolism. These analytes could be potential biomarkers to ensure the diagnosis of a GHB intoxication and even prolong the detection window. Within this study, forensic routine cases were measured to consider the potential of additional gas chromatographic mass spectrometric analysis on these acids. 17 GHB positive real cases (10 serum samples and 7 urine samples) and 40 cases with suspicion of drugging in DFC cases and negative GHB results (21 serum samples and 19 urine samples) were evaluated. Increased GHB related acid concentrations were detected in a…

Near‐field optical addressing of single molecules in coplanar geometry: a theoretical study

2001

Photonic transfer through elongated optical structures of submicrometre section microfabricated at the surface of dielectric or semiconductor samples can be enhanced by an appropriate structuring of the local refraction index. We show from computerized simulations that both the light localization and the spectroscopic properties of such structures can be used to selectively excite, in coplanar geometry, individuals molecules located in the near-field.

Lysosomal and Peroxisomal Disorders. Recent Advances: Introduction

2006

Disciplines and thematics of scientific research in police training (1988-2012)

2014

Purpose – The purpose of this paper is to analyze the disciplines and thematic study of scientific production in police training over the period 1988-2012. Design/methodology/approach – Introduction and homogenization of keywords and assigning of descriptors to documents, thematic categorization of journals and, analysis of indicators of productivity and relationship of descriptors and thematic areas has been the used methodology. Findings – Totally, 59 different descriptors of a total of 585 assigned to the 182 articles that were published in 95 journals belonging into 20 different subject areas have been identified. The most frequent descriptors are “skills,” “management development” and…

Histological and immunohistochemical findings in a fatal case of thrombotic thrombocytopenia after ChAdOx1 nCov-19 vaccination

2021

This case report describes a fatal case of a young woman with superior sagittal, transverse and sigmoid sinus thrombosis after administration of the ChAdOx1 nCov-19 vaccination. Eleven days post-vaccination she was found unconscious and transferred to the Emergency Department. Blood parameters showed low platelets, and a CT scan showed an extensive left intracranial hemorrhage and the presence of an occlusive thrombus of the superior sagittal sinus. She under-went a craniectomy, but after the intervention, she remained in a comatose state. After a few days, her clinical conditions worsened, and she died. A complete autopsy was performed which showed a thrombosis of the cerebral venous distr…

Audiologic profile of OSAS and simple snoring patients: the effect of chronic nocturnal intermittent hypoxia on auditory function

2016

The objective of this work was to study the effect of nocturnal intermittent hypoxia on auditory function of simple snoring patients and subjects affected by OSAS; we compared the audiologic profile with the severity of OSAS to detect early signs of cochlear damage. One hundred-sixty patients underwent overnight polysomnography, micro-otoscopy, multi-frequency audiometry, acufenometry, TEOAE recording and d-ROMs test. All subjects were divided in four groups, based on presence/absence of AHI (simple snoring without OSAS, mild OSAS, moderate OSAS, severe OSAS). Sixty (37.5 %) patients were not affected by OSAS, 58 (36.25 %) presented a mild OSAS, 18 (11.25 %) a moderate OSAS and 24 (15 %) a …

Improved section bonding using silanated glass slides--application protocol.

1992

Silanated slides provide excellent tissue adhesion for routine histology, immunohistochemistry and in situ hybridization of frozen, paraffin embedded material or cell smears. An easy and inexpensive method of treating glass microscope slides with triethoxysilylpropylamine is reported.

Analysis of p53 and mdm2 proteins in malignant fibrous histiocytoma in absence of gene alteration: prognostic significance.

2000

TP53 and MDM2 genes and their protein expression were evaluated in frozen and paraffin-embedded tissue from 27 patients with malignant fibrous histiocytoma to elucidate the relationship between them, their implication in tumor progression mechanisms and their possible diagnostic-prognostic value in malignant fibrous histiocytoma. Single-strand conformation polymorphism analysis and direct sequencing of polymerase chain reaction-amplified DNA were used to establish two TP53 mutations (7.4%): a point mutation and a 63-bp duplication. Amplification of the MDM2 gene was observed in two tumors (7.4%) by means of Southern-blot analysis, one of them also carrying the TP53 point mutation. Immunohis…

More about the developing of invisible lipstick-contaminated lipmarks on human skin: The usefulness of fluorescent dyes

2006

At the present time fingerprints are one of the simplest, and most reliable means of identification. Increasingly, crime scene investigators look for palm, foot, ear or lip prints. With regard to lip prints, the use, very common today, of protective or permanent lipsticks allow the production an invisible lipmark (or invisible lipstick-contaminated lipmark) which is possible to develop. Some results have already been published about developers useful for different kinds of surfaces (both porous and non-porous) as well as those which are more efficient in case of old or recent prints. The latest studies are about the developing on human skin, and they prove the usefulness of lysochromes (spe…