Search results for "PaxGene"

Transgene verification and technical improvement in the establisment of transgenic miR-32 mouse line

2015

The main challenge to be faced with prostate cancer (PCa) is the segregation and treatment of patients with life-threatening disease. As current prognostic, diagnostic and therapeutic tools are insufficient, solution is tried to be found from new biomarkers. One of these could be microRNA miR-32, which is possible up-regulated target of androgen receptor in aggressive PCa. Btg2 and Klf2 have further been suggested to be potential down-regulated miR-32 targets. To study hypothesized miR-32 oncogenicity in vivo, transgenic mice over-expressing miR-32 specifically in the prostate are established. Establishment of transgenic mouse line is a prolonged process, in which transgene functionality ne…