Search results for "Pb"
showing 10 items of 3522 documents
Different Transcriptional Activity and In Vitro TNF-α Production in Psoriasis Patients Carrying the TNF-α 238A Promoter Polymorphism
2000
Genes encoded on chromosome 6 within the major histocompatibility complex region are thought to play an important role in the pathogenesis of psoriasis. A potential candidate gene is tumor necrosis factor alpha. The tumor necrosis factor alpha promoter contains several polymorphisms including two G--A transitions at position -308 and -238, which are the most common in Caucasian populations. The TNF238.2 (-238A) allele has been strongly associated with psoriasis. We have investigated the effect of the -238 and -308 variants on transcription of the tumor necrosis factor alpha gene in luciferase reporter gene assays. In addition, peripheral blood mononuclear cells of 47 patients with psoriasis…
Effect of the -420C/G variant of the resistin gene promoter on metabolic syndrome, obesity, myocardial infarction and kidney dysfunction.
2007
. Objective. Resistin is an adipokine that has been suggested to be correlated with markers of inflammation and to be predictive of coronary atherosclerosis and type II diabetes in humans. A common single nucleotide polymorphism (SNP) (−420C/G) in the promoter of resistin is associated with increased resistin plasma levels and susceptibility to type II diabetes. The aim of this study was to investigate the association of the -420C/G polymorphism with metabolic syndrome, obesity, myocardial infarction and kidney disease. Design and results. First we studied 1542 subjects from the PLIC study (a population based cohort). GG carriers showed an higher prevalence of obesity and metabolic syndro…
Nociceptin/orphanin FQ opioid receptor (NOP) selective ligand MCOPPB links anxiolytic and senolytic effects
2021
Accumulation of senescent cells may drive age-associated alterations and pathologies. Senolytics are promising therapeutics that can preferentially eliminate senescent cells. Here, we performed a high-throughput automatized screening (HTS) of the commercial LOPAC®Pfizer library on aphidicolin-induced senescent human fibroblasts, to identify novel senolytics. We discovered the nociceptin receptor FQ opioid receptor (NOP) selective ligand 1-[1-(1-methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole (MCOPPB, a compound previously studied as potential anxiolytic) as the best scoring hit. The ability of MCOPPB to eliminate senescent cells in in vitro models was further tested…
Symmetry and models of single-walled TiO2 nanotubes with rectangular morphology
2011
Abstract The formalism of line symmetry groups for one-periodic (1D) nanostructures with rotohelical symmetry has been applied for symmetry analysis of single-walled titania nanotubes (SW TiO2 NTs) formed by rolling up the stoichiometric two-periodic (2D) slabs of anatase structure. Either six- or twelve-layer (101) slabs have been cut from TiO2 crystal in a stable anatase phase. After structural optimization, the latter keeps the centered rectangular symmetry of initial slab slightly compressed along a direction coincided with large sides of elemental rectangles. We have considered two sets of SW TiO2 NTs with optimized six- and twelve-layer structures, which possess chiralities (−n, n) an…
Sub-lethal Doses of Polybrominated Diphenyl Ethers, in Vitro, Promote Oxidative Stress and Modulate Molecular Markers Related to Cell Cycle, Antioxid…
2019
In the present study, we evaluated the effects of different concentrations of the polybrominated diphenyl ethers (PBDEs) BDE-209, BDE-47 and BDE-99, on the vitality and oxidative stress of a HS-68 human cell culture exposed to the compounds for three days. The results showed that for this exposure time, only the highest concentrations produced a significant vitality reduction and oxidative stress induction (p <
Evaluación de las actividades realizadas mediante la metodología de Aprendizaje Basado en Problemas
2020
[ES] La metodología de Aprendizaje Basado en Problemas (ABP) requiere un enfoque de evaluación en el que se evalúen una serie de competencias específicas y transversales. Esta evaluación debe de tener un carácter formativo que permita a los estudiantes identificar y corregir los errores a tiempo. Por lo tanto, es necesario disponer de herramientas para poder evaluar apropiadamente los resultados de aprendizaje y las competencias establecidas. En la asignatura de Corrosión de segundo de Máster de Ingeniería Química, el ABP se ha evaluado a través de un informe a entregar tras cada sesión de ABP, en donde se recogen las principales conclusiones tras la resolución cooperativa del problema plan…
An innovative approach to manage uncertainties and stock diversity in the EPBD cost-optimal methodology
2018
The EU Energy Performance of Buildings Directive (EPBD) 2010/31/EU is a step in the right direction to promote near zero energy buildings (NZEB) in a step-wise manner, starting with minimum energy performance and cost optimal thresholds for “reference buildings” (RBs) for each category. Nevertheless, a standard method for defining RBs does not exist, which led to a great divergence between MS in the level of detail used to define RBs for the EPBD cost-optimal analysis. Such lack of harmonisation between MS is further evident given the resulting large discrepancies in energy performance indicators even between countries having similar climate. Furthermore, discrepancies of 30% or higher betw…
Grabfunde aus Estland: eine archäologische Studie
1896
"Table 10" of "Exploration of jet substructure using iterative declustering in pp and Pb-Pb collisions at LHC energies"
2022
Detector-level Pb--Pb distributions of $z_{\rm g}$ for $R=0.4$ jets with minimum angular separation of subjets $\DeltaR>0.1$ for jets in the range $80 \leq p_{\rm T,jet}^{\rm ch} < 120$ GeV/$c$.
"Table 12" of "Exploration of jet substructure using iterative declustering in pp and Pb-Pb collisions at LHC energies"
2022
Detector-level Pb--Pb distributions of $z_{\rm g}$ for $R=0.4$ jets with maximum angular separation of subjets $\DeltaR<0.1$ for jets in the range $80 \leq p_{\rm T,jet}^{\rm ch} < 120$ GeV/$c$.