Search results for "Pediatrics"

O26 Population pharmacokinetic meta-analysis of individual data to design the first randomized efficacy trial of vancomycin in neonates and young Inf…

2019

BackgroundIn the absence of consensus, the present meta-analysis was performed to determine an optimal dosing regimen of vancomycin for neonates.MethodsA ‘meta-model’ using NONMEM with 4894 concentrations from 1631 neonates was built and Monte Carlo simulations were performed to design an optimal intermittent infusion, aiming at reaching a target AUC0-24 of 400 mg*h/L at steady state in at least 80% of neonates.ResultsA two-compartment model best fitted the data. Current weight, post-menstrual age (PMA) and serum creatinine were the significant covariates for clearance (CL). After model validation, simulations showed that a loading dose (25 mg/kg) and a maintenance dose (15 mg/kg twice dail…

1440 Child Mortality Under Five in Latvia, Causal Relationship and Reduction Possibilities in An International Context

2010

Background and aims: To identify the reasons of the continuously highest infant and under five mortality (U5M) rates in Latvia (since restoration of independence) within EU - 25, in order to find solutions to minimize the mortality rate in accordance with Millenium Development Goals (MDG). Methods: Analytical study of statistical data bases was performed by monitoring reports, private publications to find causal relationship in international aspect between U5M in Latvia and following factors: GDP, health budget per capita, Gini coefficient, medical service availability, etc. Results: Structure of U5M in Latvia differs from EU-25, being 2 to 10 times higher by reason of external causes of de…

Aetiology for the covariation between combined type ADHD and reading difficulties in a family study: the role of IQ

2012

Background: Twin studies using both clinical and population-based samples suggest that the frequent co-occurrence of attention deficit hyperactivity disorder (ADHD) and reading ability/disability (RD) is largely driven by shared genetic influences. While both disorders are associated with lower IQ, recent twin data suggest that the shared genetic variability between reading difficulties and ADHD inattention symptoms is largely independent from genetic influences contributing to general cognitive ability. The current study aimed to extend the previous findings that were based on rating scale measures in a population sample by examining the generalisability of the findings to a clinical popul…

Genetic risk profiles for a childhood with severely overweight

2013

Summary What is already known about this subject Genome-wide association studies have identified susceptibility loci, conferring only small effects to obesity. We selected 12 from the most accepted susceptibility genes to overweight, which have been corroborated in different populations and series of thousands of adult individuals. Single-nucleotide polymorphisms variants can have a cumulative effect on common forms of obesity, to create a genetic risk score. What this study adds We concentrated on 109 single-nucleotide polymorphisms (SNPs) located in 12 loci previously reported in association to body mass index at genome-wide significant level, for individuals of European ancestry. To iden…

The Severe Asthma Registry – German data

2018

Patients with severe persistent asthma represent the highest unmet medical need among the asthmatic population. To improve the understanding of underlying mechanisms and disease progression the German Asthma Net (GAN, www.german-asthma-net.de) launched a Severe Asthma Registry in December 2011. Enrolled patients undergo detailed clinical and physiologic evaluations, including patients’ medical history, allergy and lung function tests, blood analyses as well as past and concomitant medication and comorbidities. Patients are followed up every year. As of February 2018, 1097 subjects were recruited in Germany, Austria, and Slovenia. The mean age±SEM of the 839 German adult patients is 50.6±0.5…

Transfusion Therapy in a Multi-Ethnic Sickle Cell Population Real-World Practice. a Preliminary Data Analysis of Multicentre Survey

2018

Abstract Introduction. Despite the increasing of number of patients with Sickle Cell Disease (SCD) in Italy, due to multi-ethnic migratory phenomena, a large percentage of Caucasian sickle population is already present in Italy mainly with b-thal/HbS genotype. Red cell transfusion is one effective treatment for both acute and chronic complications of SCD, while hydroxycarbamide (HC) is used to reduce the frequency of painful vaso-occlusive crises (VOCs) and decrease the need for blood transfusion. Through the National Comprehensive Reference Centers for SCD, the Italian Society of Thalassemia and Hemoglobinopathies (SITE), in collaboration with the Society Italian Transfusion Medicine and I…

Severe Sepsis Due To Community-acquired Pneumonia (CAP) In Population Under Age 65

2010

Geographical Disparities in Multiple Myeloma Survival in Three French Regions

2016

Abstract Introduction: Within the past decade, new therapeutic agents for Multiple Myeloma (MM) have improved survival of patients included in clinical trials. The aim of this study was to measure and compare characteristics and survival of patients with MM in different French regions in the general population. Methods: All incident cases with MM (ICD-O-3 codes, 9732/3 and) between January 1, 2008 and December 31, 2009 in the French population-based Hematological Malignancies registries (Calvados, Côte d'Or and Gironde) were included. The end point of follow-up was January 1, 2015. Specific clinical information was recorded from clinical charts. Incidence rates were calculated using estimat…

Frequency of mesiodens in the pediatric population in North India: A radiographic study

2013

Objectives: Mesiodens are the most common supernumerary teeth, occurring in 0.15% to 2.2% of the population. The aim of the present study was to analyze the frequency and radiological features of mesiodens in the pediatric population. Material and methods: The study was based on the radiographic evaluation of 4133 pediatric patients of the age range of 4-15 years, attending the Department of Oral Medicine and Radiology during the time period between September 2008 to December 2012. In addition to the presence of a supernumerary tooth between the 2 central incisors, data regarding the number, position, shape and associated complications were also recorded. Results: The prevalence of mesioden…

Epidemiology of Mantle Cell Lymphoma: A Population-Based Study in France

2011

Abstract Abstract 5222 Introduction: Mantle cell lymphoma (MCL) is an aggressive and rare B-cell lymphoma entity representing around 5–8% of non-Hodgkin's lymphomas in adults. To our knowledge no data is available on the epidemiology of MCL in France. We aimed to describe incidence, survival and main clinical characteristics of MCL in a French population. Methods: Patients diagnosed with MCL were identified in three administrative areas covered by an haematological malignancies registry: the Côte d'Or (from 1988 to 2008), the Basse-Normandie (from 1997 to 2006) and the Gironde (from 2002 to 2006). Main clinical features and management characteristics were collected. World age-standardised …