Search results for "Pediatrics"

Luspatercept Response in ESA-NaïVe/RS+ Patients and RS- Patients with Low-Intermediate Risk Myelodysplastic Syndromes (MDS)

2016

Abstract Background: Management of anemia is a common therapeutic challenge in patients with myelodysplastic syndromes (MDS). Luspatercept (ACE-536), a fusion protein containing modified activin receptor type IIB, is being developed for treatment of anemia in lower-risk MDS. Luspatercept binds GDF11 and other TGF-β superfamily ligands to promote late-stage erythroid differentiation and increase hemoglobin (Hgb) levels (Suragani R, Nat Med, 2014 and Attie K, Am J Hematol, 2014). Aims: This is an ongoing, phase 2, multicenter, open-label study to evaluate the effects of luspatercept in patient (pts) with low-intermediate risk MDS. Endpoints included erythroid response (IWG HI-E), RBC transfus…

MODIFICATION OF COAGULATION IMBALANCE DURING ANTITHROMBIN TREATMENT IN PREECLAMPTIC PATIENTS: OUR EXPERIENCE

2008

Preeclamptic conditions are often associated with a natural inhibitor consumption. Many studies have evidenced validity of antithrombin (AT) treatment during preeclamptic conditions. The aim of the study is to restore a congruous coagulation imbalance with administration of AT under the guide of thromboelastographic monitoring (TEG).

I06 Dysphagia In Huntington`s Disease: A Multicenter Study

2014

Background Dysphagia is a common complication of neurogenerative disorders, and a leading cause of death due to aspiration pneumonia. Little is known about the frequency and the characteristics of dysphagia in HD. Well-balanced strategies for treatment and prevention of dysphagia in HD are lacking. Objetives To determine the prevalence of dysphagia in HD. Methods National, multicenter, observational, cross-sectional Study (Spanish EHDN). Dysphagia was assessed using the questionnaire EAT-10 (eating assessment tool), caregiver burden using the SumaCare, functional capacity using the TFC score, disease severity using the Unified HD Rating Scale (UHDRS), psyquiatric status (PBA-s), nutritional…

Les accidents vasculaires cérébraux du sujet âgé : ce que nous a appris l’épidémiologie du sujet jeune

2008

Stroke in the elderly has more major differences compared to young people: it is the first complication of atherothrombosis disease associated with the following risk factors: hypertension, diabetes, hypercholesterolemia, tobacco consumption and sleep apnea syndrome; AVC is the first consequence of atrial fibrillation; from a clinical point of view, seizure at the onset of the stroke is more frequent; prognosis is characterized by a high risk of dementia (20%); primary and secondary prevention is very efficacious even in very old patients, not only on the risk of stroke, but also on the risk of dementia; time trends at Dijon show a slight decrease of incidence rates of stroke only over 85 y…

Effective childhood cancer treatment: The impact of large scale clinical trials in Germany and Austria

2013

In Germany and Austria, more than 90% of pediatric cancer patients are enrolled into nationwide disease-specific first-line clinical trials or interim registries. Essential components are a pediatric cancer registry and centralized reference laboratories, imaging review, and tumor board assistance. The five-year overall survival rate in countries where such infrastructures are established has improved from 80% since 1995. Today, treatment intensity is tailored to the individual patient's risk to provide the highest chances of survival while minimizing deleterious late effects. Multicenter clinical trials are internationalized and serve as platforms for further improvements by novel drugs an…

Psycho-oncological care in certified cancer centres-a nationwide analysis in Germany

2012

Background Over the last few years, a nationwide voluntary certification system for cancer centres has been established in Germany. To qualify for certification, cancer centres must provide psycho-oncological care to every patient who needs it. The aim of this study was to find out how many patients have been treated by a psycho-oncologist in the certified centres. Methods All cancer centres in Germany that were re-certified in 2010 provided data documenting how many patients with primary cancer received at least 30 min of psycho-oncological consultation in 2009. Results Data from n = 456 certified cancer centres were available. In the centres, a total of 36 165 patients were seen by a psyc…

P03-010-B - A novel mutation in MEFV gene is not enough

2013

Genotype-phenotype correlation is still challenging in FMF patients especially when the disease is part of a complex autoinflammatory disease.

Paradoxes in the old age – reverse epidemiology

2012

How is stroke care organised in Europe?

2016

Summary Introduction There is a wide difference in stroke care in European Countries, conditioning the performance in stroke management. Objective The authors review current national and regional stroke organisational models and their adherence to current European Stroke Organisation (ESO) guidelines across the Europe and on-going European Stroke Projects. Stroke Care Models investigated in: Austria, Switzerland, Bavaria (Germany), London and Greater Manchester in the UK, Catalonia (Spain), Lombardy Region in Italy, Poland and Northern Portugal. Discussion There is a lack of uniform stroke care in European Countries as defined by current ESO guidelines. For this reason, ESO has established …

Ernährung bei Patienten mit Kopf-Hals-Tumoren

2005

Nutrition in Patients with Head and Neck Cancer. Malnutrition is common in patients with head and neck cancer. Due to natural course of disease or therapy, malnutrition may increase. This leads to a reduced prognosis, quality of life, and should be considered in early stages of the disease. First choice is an enteral feeding via a nasogastral feeding tube or a PEG. In special cases a parenteral nutrition may be necessary.