Search results for "Peg"
showing 10 items of 460 documents
The effect of processing and molecular weight of poly(ethylenglycol) of polylactide-based scaffolds on viability and cell adhesion of SkHep1 cells
2011
Development of New Targeted Inulin Complex Nanoaggregates for siRNA Delivery in Antitumor Therapy.
2021
Here, a novel strategy of formulating efficient polymeric carriers based on the already described INU-IMI-DETA for gene material whose structural, functional, and biological properties can be modulated and improved was successfully investigated. In particular, two novel derivatives of INU-IMI-DETA graft copolymer were synthesized by chemical functionalisation with epidermal growth factor (EGF) or polyethylenglycol (PEG), named INU-IMI-DETA-EGF and INU-IMI-DETA-PEG, respectively, in order to improve the performance of already described “inulin complex nanoaggregates” (ICONs). The latter were thus prepared by appropriately mixing the two copolymers, by varying each component from 0 to 100 wt%…
Szczepienie przeciw COVID-19 przy podejrzeniu anafilaksji po pierwszej dawce szczepionki
2022
Wraz z rosnącą liczbą wykonanych szczepień przeciwko COVID-19 (p/COVID-19) wzrasta także liczba zgłaszanych reakcji o różnym obrazie klinicznym po podaniu szczepionki. Mimo że reakcje te występują stosunkowo rzadko i nie zawsze mają charakter alergiczny, to budzą lęk. Szczególnie pacjenci, którzy doznali działań niepożądanych szczepienia, często nie są kwalifikowani do podania kolejnych dawek tym samym preparatem. Rozpoznanie ciężkiej reakcji anafilaktycznej po podaniu szczepionki mRNA i/lub uczulenie na jej składniki są przeciwwskazaniami do szczepienia preparatem mRNA p/COVID-19.
 Prezentowany przypadek pacjentki przedstawia problem prawidłowej kwalifikacji reakcji, które miały miejs…
Riconfigurare i territori metroplitani. Forme di urbanizzazione e fenomeni di pressione insediativa sui sistemi di interesse naturale in Sicilia
2018
The consumption of the soil due to urbanization it is a phenomena already for many years under observations, but of which only the scientific environment has noticed the elevated environmental impact progress. From a disciplinary point of view, is possible to identify a line of research focusing on the analysis and identification of new morphologies of urbanization and on the interaction among different settlement patterns coexisting in a specific context. This reading complements with the scientific production about the forms of settlement pressure on environmental systems, producing change and deterioration on natural ecosystems and loss of biodiversity. A necessary reference for this lin…
Oxidation-responsive and "clickable" poly(ethylene glycol) via copolymerization of 2-(methylthio)ethyl glycidyl ether
2016
Poly(ethylene glycol) (PEG) is a widely used biocompatible polymer. We describe a novel epoxide monomer with methyl-thioether moiety, 2-(methylthio)ethyl glycidyl ether (MTEGE), which enables the synthesis of well-defined thioether-functional poly(ethylene glycol). Random and block mPEG-b-PMTEGE copolymers (Mw/Mn = 1.05-1.17) were obtained via anionic ring opening polymerization (AROP) with molecular weights ranging from 5 600 to 12 000 g·mol-1. The statistical copolymerization of MTEGE with ethylene oxide results in a random microstructure (rEO = 0.92 ± 0.02 and rMTEG E = 1.06 ± 0.02), which was confirmed by in situ 1H NMR kinetic studies. The random copolymers are thermorespon…
Pore size graded scaffold for selective cellular permeation
2014
Digitaalisten kuvaväärennösten tunnistaminen JPEG-pakkausta hyödyntäen
2010
Digitaalisten valokuvien muokkaamisesta on tullut hyvin helppoa ja yleistä, mikä on nostanut esille huolen valokuvien uskottavuudesta. Ongelman ratkaisuksi on esitetty erilaisia tekniikoita, joilla valokuvien aitoutta voidaan arvioida. Tarkastelen tässä tutkielmassa niin sanottuja passiivisia tekniikoita, jotka eivät edellytä kuvasta minkäänlaista ennakkotietoa, kuten vesileimaa. Vertailen viittä tällaista tekniikkaa laatimani neljä kohtaa käsittävän kriteeristön pohjalta. Vertailtavia ominaisuuksia ovat tarkkuus, tunnistetut muokkaustyypit, rajoitukset sekä vakaus vastatoimia vastaan. Vertailu osoittaa, että eräs merkittävimmistä tekniikoiden ongelmista on niiden huono toleranssi kuvan häv…
Strenču magnētiskās anomālijas ģeofizikālā izpēte
2022
Maģistra darbā tiek pētīta Strenču magnētiskā anomālija, izmantojot ģeofizikālo inversijas modelēšanu. Ģeofizikālais modelis tika veidots, balstoties uz apvienotiem, iepriekšējā gadsimtā iegūtiem ģeofizikālajiem un urbumu datiem, un jauniegūtiem papildu magnetometrijas datiem. Darba gaitā tika izveidoti magnētiskās uzņēmības un magnētisko vektoru inversijas modeļi, pēc kuriem tika veidota ģeoloģiskā un ģeofizikālā interpretācija. Tika secināts, ka magnētisko anomāliju izraisa līdz piecu kilometru dziļumā ieguļošā proterozoja kristāliskā pamatklintājā sastopamie stipri metamorfizētie granulītu fācijas ieži ar samērā augstu magnētisko uzņēmību un paliekošo magnetizāciju. Būtisku ietekmi uz mo…
EVALUATION OF BIODEGRADABILITY ON POLYSPARTAMIDE-POLYLACTIC ACID BASED NANOPARTICLES BY CHEMICAL HYDROLYSIS STUDIES POLYMER DEGRADATION AND STABILITY
2015
Here, the synthesis of two graft copolymers based on α,β-poly(N-2-hydroxyethyl)-D,L-aspartamide (PHEA) and poly(lactic acid) (PLA), the O-(2-aminoethyl)-O′-galactosyl polyethylene glycol (GAL-PEG-NH2) or the methoxypolyethylene glycol amine (H2N-PEG-OCH3) is described. Starting from the obtained PHEA-PLA-PEG-GAL and PHEA-PLA-PEG copolymers, polymeric nanoparticles were prepared by high pressure homogenization–solvent evaporation method. To demonstrate their biodegradability as a function of the matrix composition, a chemical stability study was carried out until 21 days by incubating systems in two media mimicking physiological compartments (pH 7.4 and pH 5.5). The degradability of both nan…