Search results for "Peptic"
showing 4 items of 34 documents
Pantoprazole: from drug metabolism to clinical relevance.
2008
Conditions requiring inhibition of acid secretion, such as gastro-oesophageal reflux disease (GORD), peptic ulcers, non-ulcer dyspepsia or the use of NSAIDs, are very common, and their prevalence is expecting to rise as they are seen predominantly amongst the elderly. Among the drugs available to inhibit acid secretion, proton pump inhibitors (PPI) have been shown to have the best efficacy-safety ratio and have been used widely.This paper was intended to provide an overall presentation of one of these PPIs, pantoprazole.This study was first intended to give an overview of pantoprazole, so a Medline search was conducted using pantoprazole as unique search term, without publication date restr…
Pharmacokinetic and clinical evaluation of esomeprazole and ASA for the prevention of gastroduodenal ulcers in cardiovascular patients.
2012
Low-dose aspirin (ASA, 75 - 325 mg/day) is widely used for the primary and secondary prevention of cardiovascular (CV) diseases. However, the value of primary prevention ASA is uncertain as the reduction in occlusive events needs to be weighed against the significant increase in major bleedings. Prevention with antisecretory drugs has been proposed to reduce the incidence of ASA-induced gastrointestinal (GI) bleedings, but non-adherence to gastro-protection is of concern, as it significantly increases the risk of upper GI adverse events. Beside patients and physicians education, one approach to overcome non-adherence is the development of fixed-dose combination.This review explores the resu…
Delayed-Onset Superior Mesenteric Artery Syndrome Presenting as Oesophageal Peptic Stricture
2012
Superior mesenteric artery (SMA) syndrome is an infrequent cause of vomiting and weight loss due to compression of the third part of the duodenum by the SMA. We describe the case of a 17-year-old woman, admitted to our department for progressive dysphagia and severe weight loss due to an oesophageal peptic stricture, caused by chronic acid reflux secondary to duodenal compression by the SMA. Symptoms improved after (par)enteral nutrition and repeated oesophageal dilatation, thus supporting the role of intensive medical and endoscopic intervention as an alternative to surgery, at least in some cases.
Czy należy rutynowo wykonywać endoskopię górnego odcinka przewodu pokarmowego przed naczyniowymi zabiegami rekonstrukcyjnymi?
2001
Badaniu poddano dwie grupy chorych z niedokrwieniem kończyn kwalifikowanych do leczenia rekonstrukcyjnego. W grupie pierwszej (300 chorych) u wszystkich pacjentów wykonano rutynową przedoperacyjną endoskopię górnego odcinka przewodu pokarmowego. W grupie drugiej (300 chorych) badanie endoskopowe wykonywano u chorych objawowych. Nadżerki lub też owrzodzenia w żołądku lub dwunastnicy stwierdzono u 81 chorych (27%) z grupy pierwszej — w 56 przypadkach bez jakichkolwiek klinicznych objawów choroby. U chorych niepoddanych badaniu endoskopowemu w okresie pooperacyjnym u 8 wystąpiło krwawienie z przewodu pokarmowego powodowane czynnym owrzodzeniem trawiennym. Dodatkowo u 4 chorych zmarłych z innyc…