Search results for "Performance."
showing 10 items of 4178 documents
The Graduates in the Knowledge and Innovation Society
2011
According to the crucial importance of innovation for modern economies, the role of graduates regarding innovation appears to be a major topic when their performances in the labour market at stake. Five main questions are addressed in this chapter: (1) What does innovation mean? (2) Which organisations are likely to be more innovative? (3) What role do Higher Education graduates play regarding innovation? (4) Are they equipped to do develop innovation? (5) Which are the occupations more related to innovation, and are innovative activities rewarded? The results presented in this chapter confirm that higher education graduates are crucial actors in the innovation process. The jobs of innovati…
El discurso totalitario del partido político España 2000
2016
Este artículo analiza los elementos principales del discurso del partido político español, España 2000, concebida como una formación adscrita a la corriente de «derecha radical populista». Para ello, se emplea la metodología de análisis de contenido y se aplica el modelo de «Totalismo Ideológico» propuesto por Robert Jay Lifton, que describe los elementos que caracterizan a las ideologías radicales. Como fuentes de información se utilizan las declaraciones de los líderes de la formación durante un conflicto sucedido en la ciudad de Valencia (España). La investigación muestra las particularidades totalitarias del discurso de la formación española y sus principales ejes ideológicos, que al ig…
Losing an Unexpected Throne: Deposing Second Sons of the Stuart Dynasty
2017
Two second sons of the Stuart dynasty who came as unexpected heirs to the throne lost their crown in depositions . Both of these kings, Charles I and James II , had a strong belief in a personal kingship over loyal subjects, which was at odds with the English concept of King-in-Parliament and the possibilities for subjects to participate in the rule of the kingdom. Charles I and James II lacked the natural confidence of born kings, and both tried to overcome this deficiency by overemphasizing their royal dignity. In doing so, they never realized that the generally accepted idea of a divine right of kings was to be articulated and represented, but not implemented in politics.
Impact of wage penalty on mobility return of French PhDs
2015
International audience; Expatriation of higher-education graduates raises much concern in many countries often in conjunction with talk about the brain drain. It supposedly entails a risk of losing the skills required for a competitive economy. The issue is all the more acute for PhD graduates, who are expected to play a major part in the knowledge economy. However, questions arise as to the causes of such mobility and its consequences for young graduates' individual career paths.
Programming languages for data-Intensive HPC applications: A systematic mapping study
2020
This work is a result of activities from COST Action 10406 High -Performance Modelling and Simulation for Big Data Applications (cHiPSet), funded by the European Cooperation in Science and Technology. FCT, Portugal for grants: NOVA LINCS Research Laboratory Ref. UID/ CEC/ 04516/ 2019); INESC-ID Ref. UID/CEC/50021/2019; BioISI Ref. UID/MULTI/04046/2103; LASIGE Research Unit Ref. UID/CEC/00408/ 2019. A major challenge in modelling and simulation is the need to combine expertise in both software technologies and a given scientific domain. When High-Performance Computing (HPC) is required to solve a scientific problem, software development becomes a problematic issue. Considering the complexity…
Silver ion chromatography and gas chromatography-mass spectrometry in the structural analysis of cyclic dienoic acids formed in frying oils
1995
The nature of the cyclic monoenoic fatty acids formed from linoleic acid in sunflower oil heated to 275°C has been determined by gas chromatography-mass spectrometry of the picolinyl ester derivatives, before and after hydrogenation and deuteration, and following simplification by silver ion high-performance liquid chromatography. In addition, they were examined by gas chromatography-Fourier transform infrared spectroscopy. Cyclopentene fatty acids (50% of the total monoenes) were formed from C-8 to C-12 and C-10 to C-14 of the original chain in equal amounts with unique stereochemistry. In some isomers the double bond appeared to remain in its original position, and in others it migrated t…
Stability of tacrolimus ophthalmic solution
2017
Purpose The stability of 0.3-mg/mL tacrolimus ophthalmic solution at different storage temperatures was studied. Methods A sterile ophthalmic solution of 0.3 mg/mL tacrolimus was prepared in triplicate under aseptic conditions by diluting tacrolimus in eye drops. Three aliquots of this solution were transferred into polypropylene bottles and stored at 25, 2–8, or −15 to −25 °C. Samples were collected immediately after preparation and at selected time points and assayed in triplicate using high-performance liquid chromatography (HPLC). Samples were also visually examined for macroscopic changes. The 0.3-mg/mL tacrolimus solution was also exposed to acidic treatment and heat to force its degr…
Micellar electrokinetic capillary chromatography for therapeutic drug monitoring of carbamazepine and its main metabolites.
1998
In carbamazepine (CBZ) therapy the concomitant monitoring of concentrations of CBZ and its metabolites is strictly recommended, primarily to avoid toxic side effects. Currently, clinical routine monitoring of CBZ is accomplished by high-performance liquid chromatography or immunological methods. In this study a micellar electrokinetic capillary chromatographic (MECC) method was developed for routine drug monitoring of CBZ and its main metabolites, carbamazepine 10,11-diol and carbamazepine 10,11-epoxide, in human serum or plasma samples. The MECC method enabled baseline separation of all analytes within 2.5 min. The assay revealed sufficient precision and sensitivity and the results of eith…
Automated analysis of quetiapine and other antipsychotic drugs in human blood by high performance-liquid chromatography with column-switching and spe…
2004
Abstract An automated HPLC method with column switching is described for the determination of quetiapine, clozapine, perazine, olanzapine and metabolites in blood serum. After clean-up on silica C8 material (20 μm particle size) drugs were separated on ODS Hypersil C18 material (5 μm; column size 250 mm × 4.6 mm i.d.) within 25 min and quantified by ultraviolet (UV) detection at 254 nm. The limit of quantification ranged between 10 and 50 ng/ml. At therapeutic concentrations of the drugs, the inter-assay reproducibility was below 10%. Analyses of drug concentrations in serum of 75–295 patients treated with therapeutic doses of the antipsychotic drugs revealed mean ± S.D. steady state concen…
Comparison of Dialysis and Dispersion Methods for In Vitro Release Determination of Drugs from Multilamellar Liposomes
2008
The aim of these studies was to compare dialysis and dispersion methods for determining in vitro release of propranolol, metoprolol, pindolol, and atenolol from multilamellar liposomes. Multilamellar vesicles (MLV) were prepared using hydrogenated soy-lecithin phospholipon 90H (Ph 90H) as the primary lipid. The same volume of pH 7.4 phosphate buffered saline was used as a receptor medium for both methods. Samples were withdrawn, and drug concentration was determined using HPLC. All drug-containing liposomes exhibited an initial burst release followed by a slower rate of release. The rate and extent of drug release from MLV was dependent on the physicochemical properties of the drug. For all…