Search results for "Performance."
showing 10 items of 4178 documents
Treatment of Stage III-IV Non-Small-Cell Lung Carcinoma with Vinorelbine in Combination with Ifosfamide plus MESNA: A Study by the Southern Italy Onc…
1996
Thirty-five patients affected by stage III-IV non-small-cell lung carcinomas were treated with ifosfamide 3 gr/m2 plus MESNA as uroprotector on day 1 and vinorelbine 25 mg/m2 i.v. bolus on day 1 and 8. This cycle was repeated every 21 days. Over a total of 35 evaluable patients, the overall response rate was 34% (95% CL 18-54%). One patient experienced a complete response with a duration of 7.2+ months, and 11 patients a partial response with a mean duration of 5.9+ months. Seven patients had no change and 16 improved. The overall survival was 7.6+ months. Over a total of 145 cycles, the most frequent toxicity was myelosuppression, but grade 3 leukopenia and grade 2 thrombocytopenia were se…
A randomized phase II study of estramustine phosphate versus estramustine phosphate plus etoposide in hormone refractory prostate cancer (HRPC)
2008
20632 Background: Docetaxel-based regimens represent the treatment of choice of HRPC. However, in some patients toxicity may be a concern and the quality of life may be compromised. The aim of this phase II randomized study is to investigate the efficacy and safety of low-dose chemotherapy regimen adopting a combination of EMP and VP16 in patients affected by HRPC. Methods: 54 HRPC patients were randomized between: arm A, daily oral standard dose EMP (10mg/kg) and arm B, low-dose EMP (3mg/kg) plus VP16 (25mg/mq) for 2 weeks followed by 2-weeks’rest. Systemic toxicity and hematologic exams were monitored every 2 weeks. Performance status, pain and analgesic use were evaluated according to WH…
Overview of Prognostic Systems for Hepatocellular Carcinoma and ITA.LI.CA External Validation of MESH and CNLC Classifications
2021
Simple Summary This review proposes a comprehensive overview of the main prognostic systems for HCC classified as prognostic scores, staging systems, or combined systems. Prognostic systems for HCC are usually compared in terms of homogeneity, monotonicity of gradients, and discrimination ability. However, despite the great number of published studies comparing HCC prognostic systems, it is rather difficult to identify a system that could be universally accepted as the best prognostic scheme for all HCC patients encountered in clinical practice. In order to give a contribute in this topic, we conducted a study aimed at externally validate the MESH score and the CNLC classification using the…
Cemiplimab for locally advanced and metastatic cutaneous squamous-cell carcinomas: Real-life experience from the French CAREPI study group
2021
Although cemiplimab has been approved for locally advanced (la) and metastatic (m) cutaneous squamous-cell carcinomas (CSCCs), its real-life value has not yet been demonstrated. An early-access program enrolled patients with la/mCSCCs to receive cemiplimab. Endpoints were best overall response rate (BOR), progression-free survival (PFS), overall survival (OS), duration of response (DOR) and safety. The 245 patients (mean age 77 years, 73% male, 49% prior systemic treatment, 24% immunocompromised, 27% Eastern Cooperative Oncology Group performance status (PS) ≥ 2) had laCSCCs (35%) or mCSCCs (65%). For the 240 recipients of ≥1 infusion(s), the BOR was 50.4% (complete, 21%
Hypofractionated Radiotherapy in Head and Neck Cancer Elderly Patients: A Feasibility and Safety Systematic Review for the Clinician
2021
ObjectiveRadiotherapy (RT) in the head and neck (H&N) site are undoubtedly the most challenging treatments for patients. Older and frail patients are not always able to tolerate it, and there are still no clear guidelines on the type of treatments to be preferred for them. The recommendations for Risk-Adapted H&N Cancer Radiation Therapy during the coronavirus disease 2019 (COVID-19) pandemic provided by the ASTRO-ESTRO consensus statement achieved a strong agreement about hypofractionated RT (HFRT). A systematic literature review was conducted in order to evaluate the feasibility and safety of HFRT for older patients affected by H&N malignancies.Materials and Method…
Comparison among different rainfall energy harvesting structures
2018
In this paper, an experimental comparison between different rainfall harvesting devices through the study of the electrical rectifying circuit is proposed. In more detail, three harvesting structures are considered: the cantilever, the bridge and the floating circle. Different waveforms were acquired and discussed. The processed data were compared in order to suggest the best choice for the rectifying circuit, from the simplest one to that most frequently endorsed in the technical literature.
Application of molecularly imprinted polymers in analytical chiral separations and analysis
2018
Over the last two decades the process of development and application of a new types of molecular imprinted polymer (MIP) sorbents in the field of analytical chemistry have been widely described in the literature. One of the new trends in analytical chemistry practice is the use of new types of MIP sorbents as specific sorption materials constituting the stationary phase in advanced separation techniques. The following review paper contains comprehensive information about the application of a specific and well defined MIP sorbents (with the data base in the paper about the reagents used in MIP preparation process) as stationary phases in separation techniques including high performance liqui…
A novel thermoeconomic analysis under dynamic operating conditions for space heating and cooling systems
2019
Abstract Thermoeconomic analysis allows for a deep understanding of the cost formation process within an energy system, providing insights into the possible routes for improvement. Several thermoeconomic approaches are well-established for application in systems with steady operating conditions, such as power plants, while a limited number of applications to air-conditioning systems in buildings have been proposed, due to the difficulties in dealing with very irregular load profiles and unsteady plant operating conditions. This study investigates the potential of Thermoeconomics as a support for decision making in building energy systems, proving its capability to identify trade-offs betwee…
Fiducia, Partecipazione a reti e performance economica
2014
Nell'ambito di una ricerca originale su un campione rappresentativo di imprese operanti in un numero selezionato di settori, è stato analizzato il ruolo della fiducia interpersonale e della fiducia istituzionale nel determinare una maggiore o minore propensione a collaborare; inoltre è stata approfondita la relazione fra partecipazione a reti (formali e informali) e performance economica, distinguendo anche il caso in cui le reti sono il risultato di legami forti di tipo parentale o amicale
Modelli di collaborazione fra imprese e dotazioni di capitale sociale
2014
Dopo aver esposto le principali linee di ricerca sul capitale sociale, ci si sofferma ad analizzare i principali risultati di una ricerca originale sulle imprese, dedicando particolare attenzione al ruolo dei costi di transazione e alla relazione fra cooperazione e performance economica