Search results for "Perfusion"

Precapillary Servo Control of Blood Pressure and Postcapillary Adjustment of Flow to Tissue Metabolic Status

1996

Background There are several shortcomings in current understanding of how the microvasculature maintains tissue homeostasis. Presently unresolved issues include (1) integration of the potentially conflicting needs for capillary perfusion and hydrostatic pressure regulation, (2) an understanding of signal transmission pathways for conveying information about tissue energetic status from undersupplied tissue sites to the arterioles, (3) accounting for the experimentally observed interrelations between precapillary and postcapillary resistances, and (4) an explanation of how precise local adjustment of perfusion to metabolic demands is achieved. Methods and Results A novel conceptualization o…

Objective Assessment of Pulmonary Embolism Can Be Deferred without Increased Risk

2005

Abstract Background. Management of patients with suspected Pulmonary Embolism (PE) is problematic if diagnostic imaging is not available. Pretest Clinical Probability (PCP) and D-dimer (D-d) assessment were shown to be useful to identify those high risk patients for whom empirical, protective anticoagulation is indicated (Siragusa S et al. Arch Intern Med2004;164:2477–82). Objective of the study. In consecutive patients with suspected PE, we evaluated whether PCP and D-d assessment, together with the use of low molecular weight heparins (LMWHs), allow objective appraisal of PE to be deferred for up to 72 hours. Methods. In case of deferment of diagnostic imaging for PE, patients identified …

Role of Ischemia/Reperfusion Injury in Organ Transplantation

1997

Reperfusion of oxygenated blood into previously ischemic tissue is essential to prevent the progression of cellular injury due to the decreased nutritional blood flow, i.e., the decreased delivery of oxygen and metabolic substrates, as well as the removal of harmful metabolic byproducts. However, it has become obvious that reperfusion also initiates a complex series of pathologic events that contribute to, rather than prevent, further tissue damage. Moreover, a growing body of evidence indicates that ischemia/reperfusion injury is initiated by events that occur at the level of the microcirculation. In the first part of this overview, we will delineate the major components of the microcircul…

P1742Experimental ischemic stroke in rats induce myocardial contractile dysfunction in vivo and ex vivo and increase cardiac vulnerability to ischemi…

2017

Extremitätenperfusion beim malignen Melanom: Indikation, Technik und Ergebnisse

2008

Imaging photoplethysmography for assessment of chronic pain patients

2019

In present pilot study application of multi-spectral imaging photoplethysmography for assessment of chronic pain patients during topical skin heating test was proposed. Photoplethysmography signal was recorded at 420nm, 530nm and 810nm illumination from the skin and corresponding perfusion indexes and perfusion maps were calculated. The novel parameter-PPGflare index was introduced and compared in neuropathic patients and healthy volunteers. Preliminary results suggest that neuropathic patients exhibited significantly lower PPGflare index, and that local heating substantially change PPG waveform at heat exposed skin region. Present study emphasizes advantages of imaging photoplethysmography…

Study of Post-Infarction Coronary Perfusion Using Quantitative Analysis of Myocardial Echocardiography With Intravenous Injection of Contrast

2005

Introduction and objectives. After a myocardial infarction, damage to the microcirculation indicates a worse prognosis. We compared the usefulness of the quantitative analysis of myocardial contrast echocardiography with intravenous injection of contrast (MCE-iv) with intracoronary injection (MCE-ic) for analyzing coronary perfusion. Patients and method. We studied 42 patients with a first ST-elevation myocardial infarction, single-vessel disease and a patent artery (TIMI 3, stenosis 0.75) and MCE-iv (perfusion of SonoVue, singleimage capture in 1 out of each 6 cycles with trigger set at end-systole, perfusion considered normal if >0.9). Perfusion was considered abnormal if 2 or more segmen…

Dominant frequency and complexity of electrical reentrant activation during ventricular fibrillation with releasing of NO after acute local stretchin…

2013

Ranolazine induced modifications of ventricular fibrillation activation complexity under mechanical stretch

2013

Effect of Streptomycin on Stretch-Induced Change in Myocardial Activation During Ventricular Fibrillation

2008

The aim of this study was to determine whether the changes in myocardial activation pattern resulting from acute stretching during ventricular fibrillation can be counteracted by administering a compound that blocks receptors sensitive to stretch. The study involved 16 isolated rabbit hearts, in which refractoriness and activation frequency during ventricular fibrillation were measured before, during and after localized acute stretching of the left ventricular free wall, either without (series A, n=8) or with (series B, n=8) the presence of streptomycin, 200 micromol. At baseline and during and after stretching, ventricular fibrillation was slower with streptomycin perfusion in series B tha…