Search results for "Permissive"
showing 10 items of 21 documents
The Human Leukocyte Antigen-DPB1 Degree of Compatibility Is Determined by Its Expression Level and Mismatch Permissiveness: A German Multicenter Anal…
2021
T-cell epitope matching according to the TCE3 algorithm classifies HLA-DPB1 mismatches in permissive and non-permissive. This classification has been shown to be predictive for mortality and acute GvHD (aGvHD) events in large international cohorts. We retrospectively genotyped HLA-DPB1 in 3523 patients transplanted in Germany between 2000 and 2014 and in their unrelated donors using an Illumina amplicon-NGS based assay. Aim of the study was to evaluate DP-compatibility beyond the established TCE3 algorithm by assessing the combined effect of several DP-mismatch parameters on post-transplant outcome. We implemented an extended DP-mismatch assessment model where TCE3, DP allotype expression w…
Permissive and suppressive effects of dexamethasone on enzyme induction in hepatocyte co-cultures.
2002
1. Steroids are known to act as permissive factors in hepatocytes. This study shows that dexamethasone (DEX) is a permissive factor for induction of CYP2B1/2, CYP3A1, CYP2A1 and probably also CYP2C11 in cultures with primary rat hepatocytes. 2. The induction factor of phenobarbital (PB)-induced formation of 16beta-hydroxytestosterone (OHT), a testosterone biotransformation product predominantly formed by CYP2B1, is increased 18-fold by the addition of 32 nM DEX to the culture medium. Interestingly, higher concentrations of DEX up to 1000 nM led to a concentration-dependent maximally 5-fold decrease (p = 0.002) of phenobarbital-induced 16beta-OHT formation compared with the effect observed w…
Microbiota Depletion Promotes Human Rotavirus Replication in an Adult Mouse Model
2021
Intestinal microbiota-virus-host interaction has emerged as a key factor in mediating enteric virus pathogenicity. With the aim of analyzing whether human gut bacteria improve the inefficient replication of human rotavirus in mice, we performed fecal microbiota transplant (FMT) with healthy infants as donors in antibiotic-treated mice. We showed that a simple antibiotic treatment, irrespective of FMT, resulted in viral shedding for 6 days after challenge with the human rotavirus G1P[8] genotype Wa strain (RVwa). Rotavirus titers in feces were also significantly higher in antibiotic-treated animals with or without FMT but they were decreased in animals subject to self-FMT, where a partial re…
DECORIN EFFECTS ON PROTEOMIC PROFILING OF BREAST CANCER CELLS: AN UPDATED STUDY
2015
The malignant carcinomas are characterized by several capabilities acquired by the neoplastic cells, among which the ability to invade the extracellular matrix (ECM) and to establish a crosstalk with several ECM components. Under this respect, the extracellular microenvironment is an entity extraordinarily rich of information with opposite signals. Our group has long undertaken the study of the effects of ECM molecules on the behavior of cancer cells in vitro. Among the studied molecules, the decorin was found to exert a non-permissive effect on the growth and motility of the transfected tumor cells. The decorin, belongs to the family of small leucine-rich proteoglycans (SLRP) and is involv…
Parenting, Peer Relationships, Academic Self-efficacy, and Academic Achievement: Direct and Mediating Effects
2017
The aim of the present study is to analyze the relation between authoritative and permissive parenting styles with the kinds of adolescent peer relationships (attachment, victimization, or aggression), and of the latter ones, in turn, with academic self-efficacy, and academic performance, in three waves that range from the early-mid adolescence to late adolescence. Five hundred Spanish adolescents, of both sexes, participated in a three-wave longitudinal study in Valencia, Spain. In the first wave, adolescents were either in the third year of secondary school or the fourth year of secondary school. The mean age in the first wave was 14.70 (SD = 0.68; range = 13–16 years). Child Report of Pa…
Contrasting associations between maternal feeding styles and different dimensions of pre-schoolers' eating behaviours
2023
International audience
Parenting Styles and Internet Use
2017
The Internet has become the most popular way for young people to communicate with one another. Recent data indicate that 95% of students have Internet access. This study examined the links between Internet use and the parenting styles that shape parent-child interactions. Empirical analysis showed that Internet use accounts for the majority of adolescents' leisure time. The neglecting parenting style has the strongest relationship with addictive Internet use by adolescent girls and boys. For boys, addictive Internet use is also related to a combination of different parenting styles resulting from inconsistencies and contradictions between parents.
Are oral health conditions associated with schoolchildren’s performance and school attendance in the Kingdom of Bahrain? A life‐course perspective
2021
Background: The link between oral diseases and school performance and school attendance remains unclear among Middle Eastern children.Aim: To investigate the relationship of oral conditions with schoolchildren's school performance and attendance using the life- course approach.Design: A cross- sectional study was conducted with 466 schoolchildren aged 7- 8 years from Kingdom of Bahrain (KoB) and their parents. Questionnaire data on children's current and at- birth environmental characteristics were completed by their parents. Children's oral health measures, including ICDAS (International Caries Detection and Assessment System), PUFA (pulp, ulcer, fistula, abscess), and DDE (developmental d…
INNATE IMMUNITY AND INFLAMMATION IN AGEING: A KEY FOR UNDERSTANDING AGE-RELATED DISEASES.
2005
Abstract The process of maintaining life for the individual is a constant struggle to preserve his/her integrity. This can come at a price when immunity is involved, namely systemic inflammation. Inflammation is not per se a negative phenomenon: it is the response of the immune system to the invasion of viruses or bacteria and other pathogens. During evolution the human organism was set to live 40 or 50 years; today, however, the immune system must remain active for much a longer time. This very long activity leads to a chronic inflammation that slowly but inexorably damages one or several organs: this is a typical phenomenon linked to ageing and it is considered the major risk factor for a…
Neurotic Depression and Suicidal Ideation in Finnish Men: a Learning Theory Approach
1983
The theme of this paper is neurotic depression and suicidal ideation as studied in seventeen Finnish men between the ages of 22 and 46. These men were seen in learning-theory oriented individual psychotherapy (10-46 sessions). The results of treatment are evaluated in relation to the Finnish concept of masculine identity and particularly the difficulty experienced by fathers in achieving a close and permissive relationship with their sons, so that a boy could learn to tolerate “weaknesses” within himself.