Search results for "Persona"

Droit romain et Code Noir. Quelques réflexions a posteriori

2015

In Roman times, slavery is domestic, before conquests transformed its nature. Colonial slavery is an economic exploitation based on slave trade. How do the administrators apprehend the slave’s legal status ? Does the Code noir follow local rules or Roman precedents to supervise practice, according to some expected effects on the settlers’s property ? If Roman law serves as a matrix, is it as a simple recovery or as an indirect influence ? The spirit of antique solutions is present, but it is not essential for the legal definition of "Negros". The Roman law provides a conceptual tool to understand a posteriori the inner wheels of a specific status, at the turning point between property right…

Experiencing Effects of Cocaine and Speed with Self-Regulation Therapy.

2015

AbstractThis study demonstrates the efficacy of Self-Regulation Therapy (SRT) to induce effects of cocaine and speed in a single session. SRT is a suggestion procedure of sensorial recall exercises (salivation, feeling of weight, tension, etc.) that increases the capacity to reproduce all sensation types and those that drugs produce. The Self-Regulation Scale (SRS) measures this capacity. Four groups participated, formed according to drug use: Group 1 (uses no illegal drugs); Group 2 (experimentally uses cannabis only); Group 3 (moderate drug users); Group 4 (regular drug users, especially stimulants). All four groups participated in an SRT session to induce relaxation. No differences in th…

2015

Drug resistance still impedes successful cancer chemotherapy. A major goal of early concepts in individualized therapy was to develop in vitro tests to predict tumors' drug responsiveness. We have developed an in vitro short-term test based on nucleic acid precursor incorporation to determine clinical drug resistance. This test detects inherent and acquired resistance in vitro and transplantable syngeneic and xenografted tumors in vivo. In several clinical trials, clinical resistance was predictable with more than 90% accuracy, while drug sensitivity was detected with less accuracy (~60%). Remarkably, clinical cross-resistance to numerous drugs (multidrug resistance, broad spectrum resistan…

Pharmacogenomics in colorectal carcinomas: Future perspectives in personalized therapy

2005

The recent introduction of new drugs such as capecitabine, irinotecan, and oxaliplatinum has greatly improved the clinical outcome of patients with advanced/metastatic colorectal cancer. Nevertheless, some patients may suffer from the adverse drug reactions which will probably be the main cause of chemotherapy failure. The goal of pharmacogenomics is to find correlations between therapeutic responses to drugs and the genetic profiles of patients; the different responses to a particular drug are due, in fact, not only to the specific clinico-pathological features of the patient or to environmental factors, but also to the ethnic origins and the particular individual's genetic profile. Genes …

Learning to be a psychostimulants addict with self-regulation therapy

2018

This article presents the results of a single-case experiment of alternative treatments in which a participant applied the Self-Regulation Therapy (SRT) to reproduce the effects of a stimulant drug, methylphenidate, and a sedative, alcohol. The SRT is a learning procedure based on classic conditioning and suggestion that reproduces the effect of drugs by remembering the effects they have. The participant reproduced the effects of both drugs during ten sessions held on 5 consecutive days. To record effects, adjective scales were used that measured Drug effect, High, Rush, Energy, Tension and the General Factor of Personality (GFP). The results indicated that the participant was capable of in…

Impact of reslizumab on outcomes of severe asthmatic patients: current perspectives.

2018

Approximately 5%-10% of asthmatics suffer from severe asthma. New biological treatments represent a great opportunity to reduce asthma burden and to improve asthma patients' lives. Reslizumab will soon be available in several European countries. This anti-IL-5 IgG4/kappa monoclonal antibody, administered intravenously at a dose of 3 mg/kg over 20-50 minutes every 4 weeks, has been shown to be safe and effective in patients with 400 eosinophils/mu L or more in their peripheral blood. The clinical effects in reducing asthma exacerbations and in improving the quality of life and lung function are clear, but further research is needed to determine the best biological compound for a specific clu…

Multi-residue determination of 47 organic compounds in water, soil, sediment and fish—Turia River as case study

2017

A sensitive and reliable method based on solid-liquid extraction (SLE) using McIlvaine-Na2EDTA buffer (pH = 4.5)-methanol and solid-phase extraction (SPE) clean up prior to ultra-high-performance liquid chromatography coupled to tandem mass spectrometry (UHPLC–MS/MS) was applied to determine 47 organic contaminants in fish, soil and sediments. The SPE procedure to clean-up the extracts was also used as extraction method to determine these compounds in water. Recoveries ranged from 38 to 104% for all matrices with RSDs 50% for 36 compounds in front of 9, matrix effect < 20% for 31 compounds against 21, and LOQs <25 ng g−1 for 38 compounds against 22) indicates that the proposed method is mor…

Wastewater-based epidemiology: current status and future prospects

2019

Wastewater-based epidemiology (WBE) has been consolidated as a tool to provide real-time information on consumption of legal and illegal drugs of abuse by the population. However, WBE is expected to achieve more ambitious objectives such as establishing exposure to certain agents (pesticides, personal care products, persistent organic pollutants, and pathogens), incidence of specific diseases (diabetes, allergies, oxidative stress, and cancer), and determination of some lifestyle consequences (exposure to personal care products, consumption of doping substances or products for the treatment of erectile dysfunction) or environmental factors (increase in temperature) in populations. Herein, w…

Psychological aspects in children affected by duchenne de boulogne muscular dystrophy.

2012

Impairment of intelligence in Duchenne muscular dystrophy (DMD) patients was described by Duchenne de Boulogne himself in 1868. Further studies report intelligence disorders with mayor impairment of memory. The aim of the present study was to assess the presence of affective and personality disorders in a group of children affected by DMD. Twenty six male DMD patients, mean age eleven and four months years old, were assessed for their affective and personality disorder. Only eight subjects had a total IQ below average with major difficulties in verbal and visual-spatial memory, comprehension, arithmetic and vocabulary. All the subjects presented some disorders: tendency to marginalization a…

Aphorismen und abgerissene Gedanken über verschiedene Gegenstände des Lebens

1807

Priekšvārda beigās uzrādīts tikai autora vārds: Frederick.