Search results for "Perte"

Relationships of different defintions of metabolic syndrome and left ventricular mass in essential hypertensive patients

2010

Redox signaling (cross-talk) from and to mitochondria involves mitochondrial pores and reactive oxygen species

2010

This review highlights the important role of redox signaling between mitochondria and NADPH oxidases. Besides the definition and general importance of redox signaling, the cross-talk between mitochondrial and Nox-derived reactive oxygen species (ROS) is discussed on the basis of 4 different examples. In the first model, angiotensin-II is discussed as a trigger for NADPH oxidase activation with subsequent ROS-dependent opening of mitochondrial ATP-sensitive potassium channels leading to depolarization of mitochondrial membrane potential followed by mitochondrial ROS formation and respiratory dysfunction. This concept was supported by observations that ethidium bromide-induced mitochondrial d…

Recurrent Mutations in the Basic Domain of TWIST2 Cause Ablepharon Macrostomia and Barber-Say Syndromes

2015

Contains fulltext : 153827.pdf (Publisher’s version ) (Open Access) Ablepharon macrostomia syndrome (AMS) and Barber-Say syndrome (BSS) are rare congenital ectodermal dysplasias characterized by similar clinical features. To establish the genetic basis of AMS and BSS, we performed extensive clinical phenotyping, whole exome and candidate gene sequencing, and functional validations. We identified a recurrent de novo mutation in TWIST2 in seven independent AMS-affected families, as well as another recurrent de novo mutation affecting the same amino acid in ten independent BSS-affected families. Moreover, a genotype-phenotype correlation was observed, because the two syndromes differed based s…

Characterization of diorganotin(IV) complexes with captopril. The first crystallographically authenticated metal complex of this anti-hypertensive ag…

2003

Abstract Diorganotin(IV) complexes R 2 Sn(cap) (capH 2 = N -[( S )-3-mercapto-2-methylpropionyl]- l -proline; R=Me, Et, n -Bu and t -Bu) were prepared and characterised. The FTIR and Raman spectra demonstrated that the organotin(IV) moieties interact with the {S} atom of the ligand, while the other coordination sites are the carboxylate and the amide –CO groups. Mossbauer Δ data showed that the diorganotin(IV) compounds adopt slightly distorted trigonal-bipyramidal (tbp) geometry. A single-crystal X-ray study was performed on the compound Me 2 Sn(cap): the Sn atom is five-coordinated in a distorted tbp environment, with two {O} atoms in the axial positions and the {S} and two {C} atoms in t…

Cisternostomy: A Timely Intervention in Moderate to Severe Traumatic Brain Injuries: Rationale, Indications, and Prospects.

2019

Traumatic brain injury (TBI) represents a major public health concern worldwide, with no significant change in its epidemiology over the last 30 years. After TBI, the primary injury induces irreversible brain damage, which is untreatable. The subsequent secondary injury plays a critical role in the clinical prognosis because without effective treatment it will provide additional tissue damage. The resulting scenario is the rise in intracranial pressure (ICP) with the development of progressive neurological deficits. Current optimal management is based on a progressive, target-driven approach combining both medical and surgical treatment strategies among which is decompressive hemicraniectom…

Potential of the EPA/DHA 6/1 formulation to prevent endothelial dysfunction and cardiopulmonary remodeling in pulmonary arterial hypertension in rats

2016

Pulmonary arterial hypertension (PAH) is characterized by remodeling of the small pulmonary arteries leading to a progressive increase in pulmonary vascular resistance and right ventricular failure. Pulmonary endothelial dysfunction, inflammation and oxidative stress promote the development of pulmonary hypertension. Omega-3 polyunsaturated fatty acids such as eicosapentaenoic acid (EPA) and docosahexaenoic acids (DHA) have been shown to protect the cardiovascular system and reduce inflammation and oxidative stress. The present study evaluate the potential of EPA:DHA 6:1 to prevent monocrotaline-induced PAH in rats. EPA:DHA 6:1 treatment (500 mg/kg/d, p.o) prevented the MCT-induced mean pul…

Technology for supporting web information search and learning in Sign Language

2009

Sign Languages (SL) are underrepresented in the digital world, which contributes to the digital divide for the Deaf Community. In this paper, our goal is twofold: (1) to review the implications of current SL generation technologies for two key user web tasks, information search and learning and (2) to propose a taxonomy of the technical and functional dimensions for categorizing those technologies. The review reveals that although contents can currently be portrayed in SL by means of videos of human signers or avatars, the debate about how bilingual (text and SL) versus SL-only websites affect signers' comprehension of hypertext content emerges as an unresolved issue in need of further empi…

Reading skills and children’s navigation strategies in hypertext

2011

Prior research has identified two important navigation strategies that have a clear impact on hypertext comprehension: link selection and overview processing strategies. The first relate to the order in which students select hyperlinks while trying to comprehend a hypertext, whereas the second relate to when and for how long students process navigation overviews, a text device that conveys the text structure by displaying sections, titles and their relations. Most prior research in navigation strategies has been conducted with undergraduate students. We extend prior research by exploring the navigation strategies used by sixth-graders while reading a hypermedia system. We also investigate h…

Children's Reading of Printed Text and Hypertext with Navigation Overviews: The Role of Comprehension, Sustained Attention, and Visuo-Spatial Abiliti…

2012

Hypertexts include new structural features, such as navigable graphical overviews, that dramatically change the way students interact with texts. Nevertheless, at school students traditionally practice literacy skills appropriate for reading and comprehending printed texts. We explored the possibility that those skills might not be the same as the ones required to master hypertext reading. Specifically, we tested the hypothesis that hypertext structural features, such as navigable graphical overviews, might scaffold students with low comprehension and sustained-attention abilities, but demand higher involvement of visuo-spatial skills. Results from a group of 6th-grade students only partia…

Does collaborative hypertext support better engagement in learning of the basics in informatics?

1997

Hypertext is a powerful cognitive tool supporting knowledge construction. We organized two courses about the basics in informatics using collaborative hypertext (experimental groups) based on the hyperbooks built by the students participating in the courses. Simultaneously, we ran two courses without collaborative hypertext (control groups). The study found that collaborative hypertext affects motivation equally regarding most themes of the basics in informatics.The result reflects the need for traditional uncomputerized learning methods in the basics of informatics or the need to concentrate on improving the truthfulness of hypertext-based learning. However, some students may benefit from …