Search results for "Perte"
showing 10 items of 1643 documents
Should inflammatory pathways be targeted for the prevention and treatment of hypertension?
2019
Hypertension is the most common modifiable risk factor for cardiovascular disease (CVD)1 and is a leading cause of death globally.2 Hypertension and CVD share common antecedent risk factors which include physical inactivity, obesity and excess alcohol intake.3 Though these established risk factors explain a large proportion of hypertension risk, its pathogenesis is still not fully established as it appears that other additional lifestyle and genetic factors may be involved. There is therefore a need to identify and evaluate putative risk factors that may increase our knowledge of hypertension development, may have causal or predictive relevance, and which will help develop preventive and ma…
A new clinical classification (V.I.A.) of hypertensive heart disease: our experience
2016
Markers di fibrosi miocardica e di infiammazione in ipertesi con e senza ipertrofia ventricolare.
2006
Il “milieu” citochinico del paziente cirrotico tra circolazione iperdinamica e bilancio simpato-vagale: il ruolo di Osteopontina, IL-22, IL-6, IL-17,…
2022
Markers of myocardial fibrosis and inflammation in hypertensives with and without left ventricular hypertrophy
2006
Contenedor Hipermedia de Estadística Aplicada a la Economía y Ciencias Sociales (CEACES): una aproximación
2010
En el articulo se pretende llevar a cabo una breve aproximacion al trabajo realizado en el entorno de la consecucion del proyecto CEACES. Por otro lado se sugieren las formas y metodos utilizados en la realizacion y desarrollo del proyecto. Por ultimo se lleva a cabo un pequeno recorrido a traves del trabajo realizado para mostrar algunos de los aspectos mas interesantes del mismo
A non-canonical chemical feedback self-limits nitric oxide-cyclic GMP signaling in health and disease
2018
Endothelial nitric oxide (NO) stimulates the heme protein, soluble guanylyl cyclase (sGC) to form vasoprotective cyclic GMP (cGMP). In different disease states such as pulmonary hypertension, NO-cGMP signaling is pharmacologically augmented, yet the pathomechanisms leading to its dysregulation are incompletely understood. Here we show in pulmonary artery endothelial cells that endogenous NO or NO donor compounds acutely stimulate sGC activity, but chronically down-regulate both sGC protein and cGMP formation. Surprisingly, this endogenous feedback mechanism was independent of canonical cGMP signaling via cGMP-dependent protein kinase. It did not involve thiol-dependent modulation, a process…
Nitric oxide metabolites (nitrite and nitrate) in several clinical condition.
2013
We determined the concentration of nitric oxide metabolites (NO2-+NO3-), expressed as NOx, in several clinical conditions. Regarding this, we have examined 25 subjects with arterial hypertension, 41 subjects with chronic kidney disease in conservative treatment, 106 subjects with metabolic syndrome subdivided according to the presence (n = 43) or not (n = 63) of diabetes mellitus, 48 subjects with obstructive sleep apnea syndrome (OSAS), 14 women with systemic sclerosis complicated with Raynaud's phenomenon, 42 dialyzed subjects and 105 young subjects with acute myocardial infarction (AMI). In subjects with arterial hypertension, chronic kidney disease, metabolic syndrome, systemic sclerosi…
Interrelazioni tra disfunzione endoteliale e stress ossidativo; valutazione della perossidazione lipidica in particolari quadri clinici
2015
Il termine "disfunzione endoteliale" identifica una condizione patologica caratterizzata da ridotta vasodilatazione e da attività procoagulante e pro-infiammatoria, correlata ad una ridotta biodisponibilità di ossido nitrico (NO), ad un eccesso ossidativo e ad un'aumentata azione dell'endotelian 1 (ET-1).
Biomarcadores en hipertensión pulmonar de causa cardiaca izquierda. Valor diagnóstico y pronóstico.
2015
La hipertensión pulmonar (HP) debida a enfermedad del corazón izquierdo es una patología prevalente, grave y asociada a importante morbilidad y mortalidad, sobre todo cuando produce un deterioro de la función ventricular derecha. Dentro de esta enfermedad, existen varios tipos según la respuesta del lecho vascular pulmonar. Se asume que en la HP pasiva se inicia una disfunción endotelial que puede progresar hacia una hiperplasia vascular con grave repercusión sobre el ventrículo derecho y sin posibilidad de regresión. Actualmente, para el diagnóstico de HP es indispensable un cateterismo cardíaco derecho causante de morbilidad e incluso mortalidad. Lo que se pretende con este proyecto es in…