Search results for "Pf"
showing 10 items of 526 documents
Macrophage MerTK promotes profibrogenic cross-talk with hepatic stellate cells via soluble mediators
2022
Background & aims: Activation of Kupffer cells and recruitment of monocytes are key events in fibrogenesis. These cells release soluble mediators which induce the activation of hepatic stellate cells (HSCs), the main fibrogenic cell type within the liver. Mer tyrosine kinase (MerTK) signaling regulates multiple processes in macrophages and has been implicated in the pathogenesis of non-alcoholic steatohepatitis-related fibrosis. In this study, we explored if MerTK activation in macrophages influences the profibrogenic phenotype of HSCs. Methods: Macrophages were derived from THP-1 cells or differentiated from peripheral blood monocytes towards MerTK+/CD206+/CD163+/CD209- macrophages. Th…
Expression of Ia-antigens on guinea pig Kupffer cells
1986
Summary The expression of the Ia-antigen on guinea pig Kupffer cells was studied employing two monoclonal antibodies against two different determinants of the Ia-molecule. The study was performed in situ on liver sections and on isolated highly purified Kupffer cells kept in culture up to 6 days. The influence of guinea pig hepatocyte culture supernatant and of supernatants of phytohemoagglutinin (PHA)-stimulated human peripheral blood lymphocytes (PBL) on the Ia expression was measured. Immunofluorescence staining of cryostat sections revealed that the monoclonal antibodies used are able to detect Ia-antigens on liver macrophages in situ. The in vitro studies strongly suggest that all Kupf…
Dynamics of the caring family
2003
When several individuals simultaneously provide for offspring, as in families, the effort of any one individual will depend on the efforts of the other family members. This conflict of interest among family members is made more complicated by their relatedness because relatives share genetic interest to some degree. The conflict resolution will also be influenced by the differences in reproductive value between breeders and helpers. Here, we calculate evolutionarily stable provisioning efforts in families with up to two helpers. We explicitly consider that the behavioral choices are made in a life-history context, and we also consider how group sizes change dynamically; this affects, for ex…
Hopf algebras, renormalization and noncommutative geometry
1998
We explore the relation between the Hopf algebra associated to the renormalization of QFT and the Hopf algebra associated to the NCG computations of transverse index theory for foliations.
Quantum and Braided Integrals
2001
We give a pedagogical introduction to integration techniques appropriate for non-commutative spaces while presenting some new results as well. A rather detailed discussion outlines the motivation for adopting the Hopf algebra language. We then present some trace formulas for the integral on Hopf algebras and show how to treat the $\int 1=0$ case. We extend the discussion to braided Hopf algebras relying on diagrammatic techniques. The use of the general formulas is illustrated by explicitly worked out examples.
Global Linear Stability Analysis of the Flow Around a Superhydrophobic Circular Cylinder
2016
International audience; Over the last few years, superhydrophobic (SH) surfaces have been receiving an increasing attention in many scientific areas by virtue of their ability to enhance flow slip past solid walls and reduce the skin-friction drag. In the present study, a global linear-stability analysis is employed to investigate the influence of the SH-induced slip velocity on the primary instability of the 2D flow past a circular cylinder. The flow regions playing the role of 'wavemaker' are identified by considering the structural sensitivity of the unstable mode, thus highlighting the effect of slip on the global instability of the considered flow. In addition, a sensitivity analysis t…
Modified post-bifurcation dynamics and routes to chaos from double-Hopf bifurcations in a hyperchaotic system
2012
In order to understand the onset of hyperchaotic behavior recently observed in many systems, we study bifurcations in the modified Chen system leading from simple dynamics into chaotic regimes. In particular, we demonstrate that the existence of only one fixed point of the system in all regions of parameter space implies that this simple point attractor may only be destabilized via a Hopf or double Hopf bifurcation as system parameters are varied. Saddle-node, transcritical and pitchfork bifurcations are precluded. The normal form immediately following double Hopf bifurcations is constructed analytically by the method of multiple scales. Analysis of this generalized double Hopf normal form …
Hopf bifurcation at infinity for planar vector fields
2007
We study, from a new point of view, families of planar vector fields without singularities $ \{ X_{\mu}$  :  $-\varepsilon < \mu < \varepsilon\} $ defined on the complement of an open ball centered at the origin such that, at $\mu=0$, infinity changes from repellor to attractor, or vice versa. We also study a sort of local stability of some $C^1$ planar vector fields around infinity.
FLUCTUATION-INDUCED LOCAL OSCILLATIONS AND FRACTAL PATTERNS IN THE LATTICE LIMIT CYCLE MODEL
2003
The fractal properties of the Lattice Limit Cycle model are explored when the process is realized on a 2-dimensional square lattice support via Monte Carlo Simulations. It is shown that the structure of the steady state presents inhomogeneous fluctuations in the form of domains of identical particles. The various domains compete with one another via their borders which have self-similar, fractal structure. The fractality is more prominent, (fractal dimensions df < 2), when the parameter values are near the critical point where the Hopf bifurcation occurs. As the distance from the Hopf bifurcation increases in the parameter space the system becomes more homogeneous and the fractal dimens…
Post-Double Hopf Bifurcation Dynamics and Adaptive Synchronization of a Hyperchaotic System
2012
In this paper a four-dimensional hyperchaotic system with only one equilibrium is considered and its double Hopf bifurcations are investigated. The general post-bifurcation and stability analysis are carried out using the normal form of the system obtained via the method of multiple scales. The dynamics of the orbits predicted through the normal form comprises possible regimes of periodic solutions, two-period tori, and three-period tori in parameter space. Moreover, we show how the hyperchaotic synchronization of this system can be realized via an adaptive control scheme. Numerical simulations are included to show the effectiveness of the designed control.