Search results for "Pf"
showing 10 items of 526 documents
2019
Aims To report corneal topometric and aberrometric values in mucopolysaccharidosis (MPS) and to investigate their correlation with biomechanical corneal parameters. Methods One randomly chosen eye of 20 MPS patients with no to moderate corneal clouding and one eye of 23 healthy controls with comparable age were prospectively included into this study. Corneal surface regularity was assessed by index of surface variance (ISV), -vertical asymmetry (IVA), -height asymmetry (IHA), -height decentration (IHD); keratoconus index (KI), central keratoconus index (CKI) and Zernike indices of anterior and posterior corneal surface using Scheimpflug imaging (Pentacam). Corneal resistance factor (CRF) an…
Inhibition Mechanism of SARS‐CoV‐2 Main Protease with Ketone‐Based Inhibitors Unveiled by Multiscale Simulations: Insights for Improved Designs**
2021
Abstract We present the results of classical and QM/MM simulations for the inhibition of SARS‐CoV‐2 3CL protease by a hydroxymethylketone inhibitor, PF‐00835231. In the noncovalent complex the carbonyl oxygen atom of the warhead is placed in the oxyanion hole formed by residues 143 to 145, while P1–P3 groups are accommodated in the active site with interactions similar to those observed for the peptide substrate. According to alchemical free energy calculations, the P1′ hydroxymethyl group also contributes to the binding free energy. Covalent inhibition of the enzyme is triggered by the proton transfer from Cys145 to His41. This step is followed by the nucleophilic attack of the Sγ atom on …
Ar nāvi sodāmi noziegumi padomju krimināltiesībās
2020
Bakalaura darbs “Ar nāvi sodāmi noziegumi padomju krimināltiesībās” sniedz ieskatu padomju laika cilvēka dzīves ritējumā, kas ļauj noskaidrot, kā izpaudās totalitārisms un tam raksturīgā apspiestība, kas negatīvi varēja ietekmēt teju ikvienu, kas nepakļāvās tā laika noteiktajiem likumiem un stājās pretī grožus turošajai varai. Pētījuma mērķis ir noskaidrot, kāda veida noziegumu pastrādāšana padomju laikā bija pamats nāvessoda piespriešanai. Lai nonāktu pie izvirzītā mērķa, tiek izpētīti un salīdzināti divi tam laikam raksturīgie Kriminālkodeksi – Krievijas Padomju Federatīvās Sociālistiskās Republikas Kriminālkodekss ar Latvijas Padomju Sociālistiskās Republikas Kriminālkodeksu – un tiek ie…
Botanisches Handbuch. 5. Theil: Vier und zwanzigste Klasse des Linnéischen Pflanzensystems oder Kryptogamische Gewächse, 1. Band
1815
Erster Band der Ausgabe mit zweihundert und neunzehn ausgemalten Kupfertafeln enthält ausser den sämmtlichen Farnkräutern Deutschlands noch eine grosse Anzahl anderer aus allen Welttheilen, welche noch nicht, oder zum Theil unvollkommen, auch nur in seltnen Werken abgebildet sind. Inhalt: Vorbericht ; Verzeichniss der in der Vorrede erwähnten Schriftsteller ; Conspectus generum Filicum : Uebersicht der Gattungen der Farnkräuter ; Species Filicum ;Tab. 1-25.
HIV/HCV co-infection: putting the pieces of the puzzle together
2003
The most relevant consequence of human immunodeficiency virus (HIV) infection is the exposure of the patient to opportunistic agents. In addition, HIV may also modify the natural history of some non-opportunistic pathogens, which in turn may alter the course of HIV infection.
Lesbas meliķu pēdas romiešu lirikā: maģistra darbs
1944
La letteratura tedesca dei Narratori nordici (Sperling & Kupfer)
2019
Uso combinato di SBT e PFGE quali metodi molecolari per la tipizzazione di stipiti di Legionella pneumophila sierogruppo 1
2008
Determination of scattering in intraocular lenses by spectrophotometric measurements.
2014
This study presents a method for measuring scattering in explanted intraocular lenses (IOLs). Currently, determining scattering in IOLs is usually performed by Scheimpflug cameras and the results are expressed in the units used by this apparatus. The method we propose uses a spectrophotometer and this makes it possible to measure the total transmission of the IOL by using an integrating sphere; the direct transmission is determined by the double-beam mode. The difference between these two transmissions gives a value of the scattering in percentage values of light lost. In addition, by obtaining the spectral transmission curve, information about the most scattered wavelengths is also obtaine…
Agreement of predicted intraocular lens power using swept-source optical coherence tomography and partial coherence interferometry
2021
PURPOSE To analyze the agreement of the predicted intraocular lens (IOL) power obtained with ANTERION, IOLMaster 700 and Pentacam AXL biometers. METHODS We calculated the monofocal and trifocal IOL power using the SRK/T, Haigis, Barrett Universal II and Hoffer Q formulas for 106 eyes. IOL power agreement between devices was evaluated using the Bland-Altman method. RESULTS We found significant differences between biometers comparisons (p 0.05), with the same outcomes for medium- and long-eyes. No significant differences were found using the SRK/T, Haigis, or Hoffer Q formulas for short-eyes (p > 0.1). However, Barrett Universal II formula produced significant differences (p < 0.05) and thes…