Search results for "Pf"
showing 10 items of 526 documents
Dracocephalum ruyschiana L. (Ogre)
1915
Nordischer Drachenkopf ist find in Oger, Sandhügel an der Lindenbergschen Starsse. /// Ruiša pūķgalve, atradne: Ogre, dienvidu nogāze pie Liepkalnu ielas. /// Northern Dragon-head, deposit: Ogre, southern slope at Liepkalnu street. /// Zīmogs/ stamp: "Legit et Societati Naturae Scrutatorum Rigensi donavit Th. Anders". [Attēls no LU Muzeja kolekcijas Herbarium Latvicum (RIG II); (BOT1029_22).]
Molecular mechanisms of sorafenib action in liver cancer cells.
2012
Sorafenib, a multikinase inhibitor, recently received FDA approval for the treatment of advanced hepatocellular carcinoma (HCC). However, as the clinical application of sorafenib evolves, there is increasing interest in defining the mechanisms underlying its anti-tumor activity. Considering that this specific inhibitor could target unexpected molecules depending on the biologic context, a precise understanding of its mechanism of action could be critical to maximize its treatment efficacy, while minimizing adverse effects. Two human HCC cell lines (HepG2 and Huh7), carrying different biological and genetic characteristics, were used in this study to examine the intracellular events leading …
Immune networks: multitasking capabilities near saturation
2013
Pattern-diluted associative networks were introduced recently as models for the immune system, with nodes representing T-lymphocytes and stored patterns representing signalling protocols between T- and B-lymphocytes. It was shown earlier that in the regime of extreme pattern dilution, a system with $N_T$ T-lymphocytes can manage a number $N_B!=!\order(N_T^\delta)$ of B-lymphocytes simultaneously, with $\delta!<!1$. Here we study this model in the extensive load regime $N_B!=!\alpha N_T$, with also a high degree of pattern dilution, in agreement with immunological findings. We use graph theory and statistical mechanical analysis based on replica methods to show that in the finite-connectivit…
Immune networks: Multi-tasking capabilities at medium load
2013
Associative network models featuring multi-tasking properties have been introduced recently and studied in the low load regime, where the number $P$ of simultaneously retrievable patterns scales with the number $N$ of nodes as $P\sim \log N$. In addition to their relevance in artificial intelligence, these models are increasingly important in immunology, where stored patterns represent strategies to fight pathogens and nodes represent lymphocyte clones. They allow us to understand the crucial ability of the immune system to respond simultaneously to multiple distinct antigen invasions. Here we develop further the statistical mechanical analysis of such systems, by studying the medium load r…
Lévy–Khintchine decompositions for generating functionals on algebras associated to universal compact quantum groups
2018
We study the first and second cohomology groups of the $^*$-algebras of the universal unitary and orthogonal quantum groups $U_F^+$ and $O_F^+$. This provides valuable information for constructing and classifying L\'evy processes on these quantum groups, as pointed out by Sch\"urmann. In the case when all eigenvalues of $F^*F$ are distinct, we show that these $^*$-algebras have the properties (GC), (NC), and (LK) introduced by Sch\"urmann and studied recently by Franz, Gerhold and Thom. In the degenerate case $F=I_d$, we show that they do not have any of these properties. We also compute the second cohomology group of $U_d^+$ with trivial coefficients -- $H^2(U_d^+,{}_\epsilon\Bbb{C}_\epsil…
Deconstructing Stereotypes Through Reading Children’s Literature as Intergenerational Play: The Case of the Stepmother
2021
One of the key roles within stepfamilies, the role of stepmother has been and still is stigmatized with an aura of wickedness, produced by folk and fairy tales as well as by the media. As a review of theoretical frameworks of children’s literature indicates, there is a shortage of methodological proposals for handling such controversial topics in literary education. Thus, the objective of this chapter is to present and test a methodology for analyzing the capacity of children’s literature to shape social understanding of such intergenerational topics. This study was based on the exploration of the picture book by Gonzalez and Alberdi entitled La novia de papa tambien me quiere (My Dad’s Gir…
Genotoxic and endocrine activities of bis(hydroxyphenyl)methane (bisphenol F) and its derivatives in the HepG2 cell line
2008
International audience; Human can be exposed to bis(hydroxyphenyl)methane (bisphenol F or BPF) and its derivatives as environment and food's contaminants. This study was investigated to identify and to compare toxic potency of BPF, BFDGE, and two of BPF metabolites using in vitro methods. BPF did not induce any genic mutation in bacteria when the Ames test was performed according to the OECD guideline. In contrast, using Human cell lines and Comet assay, we demonstrated that BPF and Bisphenol F Diglycidyl Ether (BFDGE) were effective on HepG2 cell DNA fragmentation at non-cytotoxic concentrations. DHB was also positive but at higher concentrations, near its limit of solubility. Neither BPF,…
Combined Anchoring: Prosecution and defense claims as sequential anchors in the courtroom
2021
Purpose When making judgements under uncertainty not only lay people but also professional judges often rely on heuristics like a numerical anchor (e.g., a numerical sentencing demand) to generate a numerical response. As the prosecution has the privilege to present its demand first, some scholars have speculated about an anchoring���based unfair disadvantage for the defence (who has the last albeit less effective word in court). Despite the plausibility of this reasoning, it is based on a hitherto untested assumption that the first of two sequential anchors exerts a greater influence on a later judgement (a primacy effect). We argue that it is also conceivable that the last word in court h…
What drives the helpfulness of online reviews? A deep learning study of sentiment analysis, pictorial content and reviewer expertise for mature desti…
2021
Los destinos turísticos se ven cada vez más afectados por la información relacionada con los viajes que se comparte a través de las redes sociales. Basándose en teorías de proceso dual sobre cómo los individuos procesan la información, este estudio examina el papel de las rutas de procesamiento de información central y periférica en la formación de las percepciones de los consumidores sobre la utilidad de las reseñas en línea de destinos maduros. Llevamos a cabo un proceso de dos pasos para abordar la utilidad percibida del contenido generado por el usuario, un análisis de sentimiento utilizando técnicas avanzadas de aprendizaje automático (aprendizaje profundo) y un análisis de regresión. …
Are Neural Networks Imitations of Mind?
2015
Artificial neural networks are often understood as a good way to imitate mind through the web structure of neurons in brain, but the very high complexity of human brain prevents to consider neural networks as good models for human mind;anyway neural networks are good devices for computation in parallel. The difference between feed-forward and feedback neural networks is introduced; the Hopfield network and the multi-layers Perceptron are discussed. In a very weak isomorphism (not similitude) between brain and neural networks, an artificial form of short term memory and of acknowledgement, in Elman neural networks, is proposed.