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Assessment of a qualitative serological assay to screen for allergic sensitization in elderly subjects

2013

We used a commercially available specific IgE qualitative serological assay to screen for allergic sensitization. Two hundred twenty-eight elderly subjects took part in the study. Skin-prick tests (SPTs) to a panel of relevant aeroallergens present in the study area were used as the diagnostic reference procedure (gold standard). Subjects with at least one positive SPT (≥3 mml n = 76) were considered to have developed an allergic sensitization. The qualitative assay correctly classified subjects as sensitized to an allergen or not sensitized in 257 of 288 cases (accuracy, 88.9%; 95% CI, 85.0-92.0%). The qualitative assay sensitivity was 70.0 (95% CI, 58.1-79.7) and specificity was 95.7 (95%…

MalePulmonary and Respiratory Medicinemedicine.medical_specialtySettore MED/09 - Medicina InternadiagnosisPopulationPharmacologymedicine.disease_causeSensitivity and SpecificityLikelihood ratios in diagnostic testingGastroenterologySerologyAllergenElderlyPredictive Value of TestsInternal medicineRespiratory HypersensitivitymedicineHumansMass ScreeningImmunology and AllergySerologic TestseducationAgedPhadiatopeducation.field_of_studybusiness.industryAtopyReproducibility of ResultsGeneral MedicineGold standard (test)Assay sensitivityAllergensImmunoglobulin EPredictive value of testsDiagnostic odds ratioFemaleImmunizationbusiness
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