Search results for "Pharmacological"

Pharmacological interventions for somatoform disorders in adults, a Cochrane systematic review

2015

Farmakoloģija ar toksikoloģiju un receptūru: mācību grāmata studentiem un ārstiem

1942

Grāmatas nodaļas: Autora priekšvārdi. Saīsinājumi I. Vispārīgā farmakoloģija II. Zāļu parakstīšanas mācība III. Nemetālu un metālu savienojumi IV. Alifātiskās rindas organiskās substances V. Aromātiskās rindas organiskās substances VI. Alkaloīdl VII. Glikozīdi VIII. Rūgtvielas IX. Ēteriskās eļļas X. Vitamīni XI. Hormoni XII. Hormonoīdi jeb II šķiras hormoni XIII. Fermenti XIV. Baktēriju produkti un specifiskie serumi XV. Līdzekļi nespecifiskai kairināšanas, proteīna jeb imūnterapijai XVI. Pirmā palīdzība akūtas saindēšanās gadījumos XVII. Indikācijas. Personu saraksts. Reģistrs

Alteration of signaling pathways in hepatocellular carcinoma: identification of new pharmacological targets and possible prognosis markers.

2012

Alnus glutinosa (L.) Gaertn. and Alnus cordata (Loisel) Duby as new sources of safe cosmetic and pharmacological anti-melanogenic agents

2018

The genus Alnus (Betulaceae) comprises many species with a long history in traditional medicines. The crude extracts and isolated compounds from Alnus species exhibit a wide spectrum of in vitro and in vivo pharmacological activities (1). Phytochemical investigations revealed the presence of diarylheptanoids, a class of natural products typically found in Alnus genus with two aryl groups joined by a heptane chain in the main skeleton that have drawn attention due to their multiple biological properties and their therapeutic potential (2). A previous study reported that oregonin and other structurally analogous diarylheptanoids isolated from the bark of A. hirsuta showed inhibitory effects o…

Application of molecular topology to the prediction of antiparasitic activity against Giardia intestinalis and Trichomonas vaginalis of 2-Acylamino-n…

2020

Giardia intestinalis y Trichomonas vaginalis destacan por su importancia clínica. G. intestinalis causa la giardiosis, una parasitosis de gran importancia epidemiológica y clínica por presentar una elevada prevalencia. T. vaginalis causa la tricomoniasis, la enfermedad de transmisión sexual (ETS) no viral con mayor incidencia del mundo. Ambas parasitosis comparten el mismo tratamiento farmacológico: los nitroimidazoles. Se ha aplicado la topología molecular en la búsqueda de derivados del 2-Acylamino-nitro-1,3-tiazol con actividad antiparasitaria frente a G. intestinalis y T. vaginalis . Con el análisis lineal discriminante se obtuvo un modelo capaz de clasificar correctamente el 92,85 % de…

Xanthium strumarium - a potential cheap resource of plant substances for medicinal use

2019

Xanthium strumarium L. (Asteraceae) is an annual herb which reproduces solely by seed. So far its centre of origin was considered Central or South America. Recent archeological research revealed that the burs of X. strumarium were used in Yuergou site (400-200 cal BC) in the Turpan Basin of northwestern China. This plant adventive to Europe reduces germination of various crops and behaves like and aggressive invasive species. X. strumarium is the most frequently recorded plant in the field borders between the crop land and adjacent territories the agricultural areas in Bulgaria. We aim of this study is to reveal the potential of X. strumarium as a cheap source of compounds with valuable pha…

Familial amyloidosis: great progress for an orphan disease.

2015

Familial amyloidosis: Great progress for an orphan disease Ana Paula Barreiros1,2,*, Gerd Otto3, Bita Kahlen1, Andreas Teufel1,2, Peter R. Galle1 1Department of Internal Medicine I, Universitatsmedizin of the Johannes Gutenberg-University Mainz, Germany; 2Department of Internal Medicine I, Universitatsklinikum of the University Regensburg, Germany; 3Department of Hepatobiliary and Transplantation Surgery, Universitatmedizin of the Johannes Gutenberg-University Mainz, Germany. *Corresponding author. Address: Universitatsklinikum Regensburg, Department of Internal Medicine I, Franz-Josef-Strauss Allee 11, 93053 Regensburg, Germany. Tel.: +49 941-944-7021. E-mail address: Ana.Barreiros@ukr.de …

Clinical profiles and quality of care of adults with type 1 diabetes according to their cardiovascular Risk: A Multicenter, Observational, retrospect…

2021

Abstract Aims The European Society of Cardiology (ESC) recently defined cardiovascular risk classes for subjects with diabetes. Aim of this study was to explore the distribution of subjects with type 1 diabetes (T1D) by cardiovascular risk groups according to the ESC classification and to describe the quality indicators of care. Methods The study is based on data extracted from electronic medical records of patients treated at the 258 Italian diabetes centers participating in the AMD (Associazione Medici Diabetologi) Annals initiative. Patients with T1D were stratified by cardiovascular risk. Measures of intermediate outcomes, intensity/appropriateness of pharmacological treatment, and over…

Treatment of Anderson-Fabry Disease

2020

Fabry disease is an X-linked disorder of glycosphingolipid metabolism that results in progressive accumulation of neutral glycosphingolipids, predominantly globotriaosylsphingosine (Gb3) in lysosomes, as well as other cellular compartments of several tissues, causing multi-organ manifestations (acroparesthesias, hypohidrosis, angiokeratomas, signs and symptoms of cardiac, renal, cerebrovascular involvement). Pathogenic mutations lead to a deficiency of the lysosomal enzyme alpha-galactosidase A (GLA). In the presence of high clinical suspicion, a careful physical examination and specific laboratory tests are required. Finally, the diagnosis of Fabry’s disease is confirmed by the demonstrat…

LXR, prostate cancer and cholesterol: the Good, the Bad and the Ugly.

2012

International audience; Cholesterol is a fundamental molecule for life. Located in the cell membrane, this sterol participates to the cell signaling of growth factors. Inside the cell it can be converted in hormones such as androgens or modulate the immune response. Such important functions could not be solely dependent of external supply by diet hence de novo synthesis could occur from acetate in almost all mammalian cells. If a deficiency in cholesterol sourcing leads to development troubles, overstocking has been associated to various diseases such as atherosclerosis and cancers. Cholesterol homeostasis should thus be tightly regulated at the uptake, de novo synthesis, storage and export…