Search results for "Philosophy of Science"
showing 10 items of 808 documents
Todavía unas palabras sobre las venas cefálica y basílica
1993
Ever since 1879, when Josef Hyrtl first formulated his thesis that the names of the cephalic and basilic veins, as applied to the arm veins, were of Arab origin, a discussion began between philologists and historians of medicine as the former defended the Greek source of such denominations whilst the latter shared the view of the Viennese anatomist. The author, after making a critical review of the -relevant works published hitherto, unearthes a text drawn from a Persian manuscript dating back to the 15th century that, in his view, confirms the rigthness of the Viennese anatomist's thesis.
But who killed Harry?
1996
Review of Capone (2010): Perspectives on Language Use and Pragmatics. A Volume in Memory of Sorin Stati
2011
On Big Data: How should we make sense of them?
2020
The topic of Big Data is today extensively discussed, not only on the technical ground. This also depends on the fact that Big Data are frequently presented as allowing an epistemological paradigm shift in scientific research, which would be able to supersede the traditional hypothesis-driven method. In this piece, I critically scrutinize two key claims that are usually associated with this approach, namely, the fact that data speak for themselves, deflating the role of theories and models, and the primacy of correlation over causation. In so doing, I will also refer to a recent case history of data mining projects in the field of biomedicine, i.e. EXPOsOMICS. My intention is both to acknow…
The Sixth Annual Translational Stem Cell Research Conference of the New York Stem Cell Foundation
2012
The New York Stem Cell Foundation's "Sixth Annual Translational Stem Cell Research Conference" convened on October 11-12, 2011 at the Rockefeller University in New York City. Over 450 scientists, patient advocates, and stem cell research supporters from 14 countries registered for the conference. In addition to poster and platform presentations, the conference featured panels entitled "Road to the Clinic" and "The Future of Regenerative Medicine". © 2012 New York Academy of Sciences.
Anti-C1q Autoantibodies in Lupus Nephritis: Prevalence and Clinical Significance
2005
Recently, anti-C1q autoantibodies have been proposed as a useful marker in systemic lupus erythematosus (SLE) since their occurrence correlates with renal involvement and, possibly, with nephritic activity. We aimed to evaluate the prevalence of anti-C1q antibodies in patients with SLE, with and without renal involvement, and to correlate these markers' presence and levels with the activity of the disease and nephropathy. We studied 61 patients with SLE, 40 of whom had biopsy-proven lupus nephritis; 35 patients with other connective tissue diseases; and 54 healthy controls. In addition, 18 lupus nephritis patients were followed up during the disease time course. Anti-C1q antibodies were mea…
Expectation of sensory stimulation modulates brain activation during visual motion stimulation.
2005
The differential effects of visual hemifield motion stimulation during fixation of a stationary target were compared under two conditions: fixation straight ahead without any further instructions and fixation straight ahead with attention shifted to the "dark hemifield." Data from nine right-handed volunteers revealed that striate and extrastriate right hemispheric visual areas exhibited larger activations during left hemifield motion stimulation when attention was shifted to the right dark hemifield. Montreal Neurological Institute (MNI) coordinates (26, -98, -4) of the additional clusters activated in the latter condition corresponded best to the kinetic occipital region, which is known t…
Curcumin as a possible lead compound against hormone-independent, multidrug-resistant breast cancer
2009
We examine the possible evidence that the phytochemical curcumin may overcome resistance to hormonal and cytotoxic agents in breast cancer. We present our observations on MCF-7R, a multidrug-resistant (MDR) variant of the MCF-7 breast cancer cell line. In contrast to MCF-7, MCF-7R lacks aromatase and estrogen receptor alpha (ERalpha) and overexpresses the multidrug transporter ABCB1 and the products of different genes implicated in cell proliferation and survival, like c-IAP-1, NAIP, survivin, and COX-2. Nevertheless, in cytotoxicity and cell death induction assays, we found that the antitumor activity of curcumin is substantial both in MCF-7 and in MCF-7R. We elaborated the diketone system…
PECAM-1/CD31 in infarction and longevity.
2007
: Inflammation has recently proven to be associated with the pathogenesis of atherosclerosis and inflammatory genes are good candidates for the risk of developing atherosclerosis. The early phase of atherosclerosis involves the recruitment of inflammatory cells from the circulation and their transendothelial migration. This process is mainly mediated by cellular adhesion molecules, which are expressed by the vascular endothelium and by circulating leukocytes in response to several inflammatory stimuli. Adhesion of circulating cells to the arterial surface is among the first detectable events in atherogenesis. Cellular adhesion molecules, expressed by the vascular endothelium and by circulat…