Search results for "Philosophy of Science"

Primary cultures of human synovial macrophages metabolize androgens.

1996

Visual Attention Patterns Differ in Gynephilic and Androphilic Men and Women Depending on Age and Gender of Targets

2017

Visual attention patterns measured with eye-tracking techniques provide indirect clues about sexual response. This study aimed to test the category specificity of sexual responses to stimuli varying in gender and age by evaluating both early and late attention of gynephilic and androphilic men and women. We simultaneously presented sexually preferred and nonpreferred stimuli and measured time to first fixation and total duration of fixation on four areas of interest: entire body, then face, chest, and pelvis. Androphilic women's early attention patterns were nonspecific, whereas gynephilic women and both groups of men showed a category-specific pattern for the entire body. In contrast, all …

Cytokine Gene Transcription By NF-kappaB Family Members in Patients with Inflammatory Bowel Disease

1998

We examined the expression of the transcription factor NF-kappa B, a nuclear trans-acting factor known to play a key role in cytokine gene regulation, in patients with inflammatory bowel disease (IBD). It was found that LP macrophages in Crohn's disease (CD) and ulcerative colitis (UC) display high levels of NF-kappa B DNA-binding activity accompanied by an increased production of interleukin (IL)-1, IL-6, and tumor necrosis factor (TNF) alpha. Western blot studies showed an increased expression of the p50 and c-rel subunits of NF-kappa B; however, the most striking finding was an increased expression level of NF-kappa B p65 in patients with CD and UC. Selective downregulation of p65 in IBD…

Differences in Visual Attention Patterns to Sexually Mature and Immature Stimuli Between Heterosexual Sexual Offenders, Nonsexual Offenders, and Nono…

2018

Men, whether gynephilic or androphilic, show both early and late attention toward adults and not toward children. We examined early and late visual attention to sexually mature versus immature stimuli in four groups of heterosexual men: sexual offenders against children (SOAC = 18), sexual offenders against adults (SOAA = 16), nonsexual offenders (NSO = 18), and nonoffending men (NOM = 19). We simultaneously presented adult and child stimuli and measured time to first fixation, number of first fixations, total duration of fixation, and fixation count to four areas of interest: entire body, then face, chest, and pelvis. We found a significant interaction where only SOAC tended to fixate more…

Etiology of Homosexuality and Attitudes Toward Same-Sex Parenting: A Randomized Study

2013

Attribution theory suggests the hypothesis that heterosexuals' attitudes toward homosexual sexual orientation will be more negative when homosexuality is attributed to controllable causes. Our randomized study analyzed (a) whether beliefs about the genetic or environmental etiology of the homosexual sexual orientation can be immediately modified by reading a text and (b) the causal effect of attributions about the controllability (environmental etiology) or noncontrollability (genetic etiology) of homosexual sexual orientation on the rejection of same-sex parenting and their social rights. The sample was composed of 190 Spanish university students with a mean age of 22.07 years (SD = 8.46).…

Functional Magnetic Resonance Imaging Activations of Cortical Eye Fields during Saccades, Smooth Pursuit, and Optokinetic Nystagmus

2009

Saccades, smooth pursuit, and optokinetic nystagmus (OKN) are three basic eye movements in our ocular motor repertoire that enable us to explore the visual field. These eye movements are cortically controlled in different cortical eye fields, including the frontal eye fields (FEF) and parietal eye fields (PEF), as well as the motion-sensitive visual area MT+/V5. It is not known if this cortical control is organized in parallel cortico-cortical networks or in adjacent subregions of one system. Nor do we know where the specific eye fields are exactly located. Functional magnetic resonance imaging (fMRI) was used to investigate these open questions about the FEF, PEF, and MT+/V5. Activations o…

Inhibitory interhemispheric visuovisual interaction in motion perception.

2003

Findings of an earlier functional magnetic resonance imaging (fMRI) study that coherent motion stimulation of the right or left visual hemifield exhibited negative signal changes (deactivations) in the primary visual cortex and the lateral geniculate nucleus contralateral to the stimulated hemisphere were evaluated to determine the functional significance of this contralateral inhibition of the visual system. Fourteen subjects participated in a psychophysical study on the perception of single object motion (0.4 degrees /s) in one visual hemifield with or without concurrent coherent motion stimulation of the contralateral hemifield. Mean detection times for horizontal object motion (0.5 +/- …

Anxiety, Stress, and Contingent Negative Variation Reconsidered

1984

Role of proinflammatory alleles in longevity and atherosclerosis: results of studies performed on -1562C/T MMP-9 in centenarians and myocardial infar…

2007

Centenarians are characterized by marked delay or escape from age-associated diseases that cause mortality at earlier ages. Jointly, atherosclerosis and its complications, such as myocardial infarction (AMI), significantly contribute to mortality in the elderly. Inflammation is a key component of atherosclerosis and inflammatory genes are good candidates for the risk of the development of atherosclerosis. Genetic traits contribute to the risk of AMI and allelic variations in inflammatory genes should boost the risk of disease. If proinflammatory genotypes significantly contribute to the risk of AMI, alleles associated with disease susceptibility should not be included in the genetic backgro…

Torsional eye movement responses to monaural and binaural galvanic vestibular stimulation: side-to-side asymmetries.

2003

Vestibular stimulation by head accelerations always involves multisensory activation of the vestibular, somatosensory, and visual systems. Over the past few years, galvanic vestibular stimulation (GVS) has become increasingly popular for testing vestibular function for clinical and research purposes. Although GVS provides a nonphysiological stimulation, it is more selective than natural head accelerations and is thus an attractive tool for such tests. Eye movement responses elicited by GVS mainly consist of torsional and horizontal components, as first described by Hitzig in 1871. Animal experiments have shown that GVS increases the vestibular afferent spike frequency at the cathodal site a…