Search results for "Phosphines"

showing 10 items of 59 documents

Reactivity of bimetallic dibridged complexes Cp2Ta(H)(μ-H)(μ-PMe2)M′(CO)4 (M′ = Cr, Mo, W) toward two-electron donor ligands L (L = PR3, Me2P(CH2)nPM…

1998

Abstract The reaction of the heterobimetallic phosphido- and hydrido-bridged complexes Cp 2 TaH(μ-H)(μ-PMe 2 )M′(CO) 4 (M′ = Cr, Mo, W) ( 1–3 ) with phosphines (L = PPh 2 Me, PMe 2 Ph) or diphosphines (L = dmpm, dmpe) leads to Cp 2 Ta(H) 2 (μ-PMe 2 )M′(CO) 4 (L) ( 1a, 1b, c, d-3b, c, d ) with L regiospecifically coordinated to M′. Except for L = PPh 2 Me, the reaction is stereospecific, since a cis arrangement (with respect to the PMe 2 bridge) on the M′ site is obtained. The new compounds Cp 2 Ta(H) 2 (μ-PMe 2 )M′ (CO) 4 (Me 2 P(CH 2 ) 2 PMe 2 ) (M′ = Mo, W) are able to bind [Cr(CO) 5 ] fragments affording the linear trinuclear chain compounds Cp 2 Ta(H) 2 (μ-PMe 2 )M′(CO) 4 (Me 2 P(CH 5 )…

Inorganic Chemistrychemistry.chemical_compoundCrystallographyStereospecificityChemistryDiphosphinesMaterials ChemistryInfrared spectroscopyReactivity (chemistry)Electron donorPhysical and Theoretical ChemistryBimetallic stripPolyhedron
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[1,2,3]Triazolo[1,5-a]pyridyl phosphines reflecting the influence of phosphorus lone pair orientation on spectroscopic properties

2010

A series of new triazolopyridine-based phosphines has been prepared. These compounds revealed unexpected spectroscopic patterns. In particular, the NMR spectra are highly dependent on the relative conformational preference of the phosphine substituent at C7. Here, we report on their complete NMR analysis, X-ray structures and DFT calculations that confirm the particular arrangement of the phosphorus lone pair orbital related to the substituent pattern of the chosen phosphine.

IonsMagnetic Resonance Spectroscopy[CHIM.ORGA]Chemical Sciences/Organic chemistryPhosphines010405 organic chemistryStereochemistryPhosphorusMolecular ConformationSubstituentchemistry.chemical_elementPhosphorusTriazolesCrystallography X-Ray010402 general chemistry01 natural sciences3. Good health0104 chemical sciencesInorganic ChemistryNMR spectra databasechemistry.chemical_compoundCrystallographychemistryTriazolopyridineLone pairPhosphineDalton Trans.
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Lanthanide complexation with CMPO and CMPO-calix[4]arenes in solution: spectrophotometric and electrospray mass spectrometric approaches.

2007

The binding of lanthanide(III) cations with organophosphorous ligands like CMPO and related calix[4]arene-based derivatives have been investigated using two experimental methods. The stability constants of the lanthanum, europium and ytterbium complexes were first determined in methanol by UV absorption spectrophotometry in the presence of nitrate or chloride anions. The results showed that the stoichiometry and the stability of the complexes formed depend on the position of the CMPO moieties either on the wide or the narrow rim of the calixarene scaffold, the nature of the medium, the conformational mobility of the ligands. Complexation of lanthanum was also followed by ESI-mass spectromet…

LanthanideSpectrometry Mass Electrospray Ionizationmedicine.diagnostic_testChemistryPhosphinesInorganic chemistrychemistry.chemical_elementAnalytical ChemistrySolventEuropiumPhenolsStability constants of complexesLanthanumSpectrophotometryCalixareneLanthanummedicineSpectrophotometry UltravioletCalixarenesYtterbiumEuropiumStoichiometryTalanta
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Ceramide inhibits Kv currents and contributes to TP-receptor-induced vasoconstriction in rat and human pulmonary arteries

2011

et al.

MalePatch-Clamp TechniquesPhysiologyReceptors ThromboxaneSpider Venoms030204 cardiovascular system & hematologyMuscle Smooth VascularMembrane Potentialschemistry.chemical_compound0302 clinical medicineHypoxic pulmonary vasoconstrictionVasoconstrictor AgentsProtein Kinase C0303 health sciencesAniline Compounds3. Good healthSphingomyelin Phosphodiesterasemedicine.anatomical_structurePotassium Channels Voltage-GatedCirculatory systemmedicine.symptomSphingomyelinSignal TransductionBlood vesselmedicine.medical_specialtyCeramidePhosphinesMyocytes Smooth MusclePulmonary ArteryBiologyCeramidesBenzylidene Compounds03 medical and health sciencesInternal medicinemedicineAnimalsHumansRats Wistar030304 developmental biologyCell BiologySphingolipidRatsHEK293 CellsEndocrinologychemistryVasoconstriction15-Hydroxy-11 alpha9 alpha-(epoxymethano)prosta-513-dienoic AcidVascular resistanceVascular ResistancePeptidesVasoconstrictionAmerican Journal of Physiology-Cell Physiology
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High Photoluminescence Quantum Yields in Organic Semiconductor-Perovskite Composite Thin Films.

2017

One of the obstacles towards efficient radiative recombination in hybrid perovskites is a low exciton binding energy, typically in the orders of tens of meV. It has been shown that the use of electron-donor additives can lead to a substantial reduction of the non-radiative recombination in perovskite films. Herein, the approach using small molecules with semiconducting properties, which are candidates to be implemented in future optoelectronic devices, is presented. In particular, highly luminescent perovskite-organic semiconductor composite thin films have been developed, which can be processed from solution in a simple coating step. By tuning the relative concentration of methylammonium l…

Materials sciencePhotoluminescenceLuminescencePhosphinesGeneral Chemical EngineeringNanoparticle02 engineering and technologyElectroluminescence010402 general chemistry01 natural scienceslaw.inventionlawEnvironmental ChemistryGeneral Materials SciencePerovskite (structure)Titaniumbusiness.industryOxidesCalcium Compounds021001 nanoscience & nanotechnology0104 chemical sciencesOrganic semiconductorGeneral EnergySemiconductorSemiconductorsOptoelectronics0210 nano-technologybusinessLuminescenceLight-emitting diodeChemSusChem
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Anticancer Agents: Does a Phosphonium Behave Like a Gold(I) Phosphine Complex? Let a “Smart” Probe Answer!

2015

Gold phosphine complexes, such as auranofin, have been recognized for decades as antirheumatic agents. Clinical trials are now underway to validate their use in anticancer or anti-HIV treatments. However, their mechanisms of action remain unclear. A challenging question is whether the gold phosphine complex is a prodrug that is administered in an inactive precursor form or rather that the gold atom remains attached to the phosphine ligand during treatment. In this study, we present two novel gold complexes, which we compared to auranofin and to their phosphonium analogue. The chosen ligand is a phosphine-based smart probe, whose strong fluorescence depends on the presence of the gold atom. …

Models MolecularBiodistributionAuranofinPhosphinesStereochemistryAntineoplastic AgentsLigandsStructure-Activity Relationshipchemistry.chemical_compoundAuranofinNeoplasmsDrug DiscoveryTumor Cells CulturedZebrafish larvaemedicineAnimalsHumansTissue DistributionPhosphoniumZebrafishCell ProliferationMolecular StructureChemistryLigandProdrugAntirheumatic AgentsLarvaMolecular MedicineGoldPhosphineDerivative (chemistry)medicine.drugJournal of Medicinal Chemistry
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New concepts in multidentate ligand chemistry: effects of multidentarity on catalytic and spectroscopic properties of ferrocenyl polyphosphines.

2008

This tutorial review devoted to ligand chemistry deals with the design and properties of ferrocenyl polyphosphines, an original class of multidentate ligands. The development of a varied library of ferrocenyl tetra-, tri- and diphosphine ligands is reviewed. The multidentate nature of these species has led to unique spectroscopic and catalytic properties, in which the spatial proximity of phosphorus atoms is crucial. Regarding their catalytic applications, the key issues of catalyst longevity and ultralow catalyst loadings are discussed. Another part is concerned with fundamental advances gained in physical chemistry for structure elucidation by the study of the intriguing “through-space” N…

Models MolecularDenticityMagnetic Resonance SpectroscopyMetallocenesferrocenyl polyphosphinesSuzukiMolecular ConformationSonogashira coupling010402 general chemistryLigands01 natural sciencescatalystsCatalysisCatalysis[ CHIM.CATA ] Chemical Sciences/Catalysisthrough-space interactionOrganometallic CompoundsOrganic chemistryCombinatorial Chemistry Techniques[CHIM.COOR]Chemical Sciences/Coordination chemistryFerrous CompoundsAminationComputingMilieux_MISCELLANEOUSGroup 2 organometallic chemistryCombinatorial Chemistry Techniquesnuclear spin-spin coupling010405 organic chemistryChemistryLigand[ CHIM.COOR ] Chemical Sciences/Coordination chemistrySonogashiraaminationStereoisomerismGeneral ChemistryNuclear magnetic resonance spectroscopy[CHIM.CATA]Chemical Sciences/CatalysisReference StandardsCombinatorial chemistry0104 chemical sciencesmultidentarityHeckChemical Society reviews
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Thioetherification of Chloroheteroarenes: A Binuclear Catalyst Promotes Wide Scope and High Functional-Group Tolerance

2014

A constrained binuclear palladium catalyst system affords selective thioetherification of a wide range of functionalized arenethiols with chloroheteroaromatic partners with the highest turnover numbers (TONs) reported to date and tolerates a large variety of reactive functions. The scope of this system includes the coupling of thiophenols with six- and five-membered 2-chloroheteroarenes (i.e., functionalized pyridine, pyrazine, quinoline, pyrimidine, furane, and thiazole) and 3-bromoheteroarenes (i.e., pyridine and furane). Electron-rich congested thiophenols and fluorinated thiophenols are also suitable partners. The coupling of unprotected amino-2-chloropyridines with thiophenol and the s…

Models MolecularHalogenationPyrazinePhosphinesPyridineschemistry.chemical_elementSulfidesLigandsCatalysisCatalysischemistry.chemical_compoundPhenolsPyridineOrganic chemistrySulfhydryl CompoundsFuransThiazoleThiophenolOrganic ChemistryQuinolineGeneral ChemistryCombinatorial chemistryThiazoleschemistryPyrazinesFunctional groupQuinolinesPalladiumPalladiumChemistry - A European Journal
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Luminescent alkynyl-gold(i) coumarin derivatives and their biological activity

2013

The synthesis and characterization of three propynyloxycoumarins are reported in this work together with the formation of three different series of gold(i) organometallic complexes. Neutral complexes are constituted by water soluble phosphines (PTA and DAPTA) which confer water solubility to them. The X-ray crystal structure of 7-(prop-2-in-1-yloxy)-1-benzopyran-2-one and its corresponding dialkynyl complex is also shown and the formation of rectangular dimers for the gold derivative in the solid state can be observed. A detailed analysis of the absorption and emission spectra of both ligands and complexes allows us to attribute the luminescent behaviour to the coumarin organic ligand. More…

Models MolecularLuminescenceThioredoxin-Disulfide ReductasePhosphinesAntineoplastic AgentsCrystal structureCrystallography X-RayPhotochemistryInorganic ChemistryMetalchemistry.chemical_compoundCoumarinsCell Line TumorNeoplasmsPolymer chemistryHumansPropynyloxycoumarins; Gold(I) complexes; X-ray crystallography; Luminiscence; Biological activityta116Aqueous solutionLigandWaterBiological activityCoumarinSolubilitychemistryvisual_artvisual_art.visual_art_mediumDrug Screening Assays AntitumorLuminescencePhosphorescenceOrganogold CompoundsDalton Trans.
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Congested ferrocenyl polyphosphanes bearing electron-donating or electron-withdrawing phosphanyl groups: assessment of metallocene conformation from …

2011

International audience; The synthesis of novel substituted cyclopentadienyl salts that incorporate both a congested branched alkyl group (tert-butyl, (triphenyl)methyl, or tri(4-tert-butyl)phenylmethyl) and a phosphanyl group is reported. The introduction of either electron-withdrawing or electron-donating substituents (furyl, i-propyl, cyclohexyl, tert-butyl) on P atoms was generally achieved in high yield. The modular synthesis of ferrocenyl polyphosphanes from an assembly of these cyclopentadienyl salts was investigated, leading to the formation of new triphosphanes (denoted as 9-12) and diphosphanes (denoted as 14-16). The resulting phosphanes are not sensitive to air or moisture, even …

Models MolecularMagnetic Resonance SpectroscopyStereochemistryMetallocenesPhosphinesMolecular Conformationchemistry.chemical_elementElectronsElectron[CHIM.INOR]Chemical Sciences/Inorganic chemistry010402 general chemistryChlorobenzenes01 natural sciencesMedicinal chemistryCatalysisCatalysisInorganic Chemistrychemistry.chemical_compoundCyclopentadienyl complexOrganometallic CompoundsFerrous CompoundsPhysical and Theoretical ChemistrySpin (physics)Alkylchemistry.chemical_classification010405 organic chemistry[ CHIM.INOR ] Chemical Sciences/Inorganic chemistry0104 chemical scienceschemistryPolar effectMetallocenePalladiumPalladium
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