Search results for "Phosphorane"

showing 10 items of 13 documents

Ferrocenylbis(ylene) phosphoranes

1997

The ferrocenylbis(methylene)phosphorane Fc-P(=CTms 2 ) 2 ( 1 ) (Fc = −C 5 H 4 FeC 5 H 5 ) can be synthesized starting from ferrocenyldichlorophosphane FcPCl 2 or ferrocenyldilithiophosphane FcPLl 2 . The X-ray structure of ( 1 ) shows some unusual structural features, which indicate considerable electronic interaction of the ferrocenyl group and the σ 3 λ 5 -phosphorane unit. As a consequence of this interaction, the rotational barrier of the methylene bonds is extraordinary low. Therefore, in contrast to other bis(methylene)phosphoranes, the endo - and exo -Tms groups are indistinguishable on the NMR time scale even at −100°C. The analogous ferrocenylbis(imino)phosphorane Fc-P(=NTms) 2 ( 9…

Addition reactionStereochemistryOrganic Chemistrychemistry.chemical_elementBiochemistryPhosphoraneNitrogenInorganic Chemistrychemistry.chemical_compoundchemistryReagentElectrophileX-ray crystallographyMaterials ChemistryFerrocenyl groupPhysical and Theoretical ChemistryMethyleneJournal of Organometallic Chemistry

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Cytotoxic hydrophilic iminophosphorane coordination compounds of d8 metals. Studies of their interactions with DNA and HSA

2012

The synthesis and characterization of a new water-soluble N,N-chelating iminophosphorane ligand TPAN-C(O)-2-NC(5)H(4) (N,N-IM) (1) and its d(8) (Au(III), Pd(II) and Pt(II)) coordination complexes are reported. The structures of cationic [AuCl(2)(N,N-IM)]ClO(4) (2) and neutral [MCl(2)(N,N-IM)] M=Pd (3), Pt(4) complexes were determined by X-ray diffraction studies or by means of density-functional calculations. While the Pd and Pt compounds are stable in mixtures of DMSO/H(2)O over 4 days, the gold derivative (2) decomposes quickly to TPAO and previously reported neutral gold(III) compound [AuCl(2)(N,N-H)] 5 (containing the chelating N,N-fragment HN-C(O)-2-NC(5)H(4)). The cytotoxicities of co…

Circular dichroismMagnetic Resonance SpectroscopyStereochemistryPhosphoranesAntineoplastic AgentsBiochemistryMedicinal chemistryArticleCoordination complexInorganic ChemistryX-Ray DiffractionCell Line TumorSpectroscopy Fourier Transform InfraredmedicineHumansChelationSerum Albuminchemistry.chemical_classificationCisplatinLigandCircular DichroismIsothermal titration calorimetryDNANuclear magnetic resonance spectroscopyHuman serum albuminSpectrometry FluorescencechemistryMetalsCisplatinHydrophobic and Hydrophilic Interactionsmedicine.drugJournal of Inorganic Biochemistry

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In Vitro and in Vivo Evaluation of Water-Soluble Iminophosphorane Ruthenium(II) Compounds. A Potential Chemotherapeutic Agent for Triple Negative Bre…

2014

A series of organometallic ruthenium(II) complexes containing iminophosphorane ligands have been synthesized and characterized. Cationic compounds with chloride as counterion are soluble in water (70–100 mg/mL). Most compounds (especially highly water-soluble 2) are more cytotoxic to a number of human cancer cell lines than cisplatin. Initial mechanistic studies indicate that the cell death type for these compounds is mainly through canonical or caspase-dependent apoptosis, nondependent on p53, and that the compounds do not interact with DNA or inhibit protease cathepsin B. In vivo experiments of 2 on MDA-MB-231 xenografts in NOD.CB17-Prkdc SCID/J mice showed an impressive tumor reduction (…

Programmed cell deathStereochemistryPhosphoranesAntineoplastic AgentsTriple Negative Breast NeoplasmsMice SCIDPharmacologyIn Vitro TechniquesArticleRutheniumIn vivoCoordination ComplexesMice Inbred NODDrug DiscoverymedicineOrganometallic CompoundsCytotoxic T cellAnimalsHumansCathepsinCisplatinChemistryWaterIn vitro3. Good healthHEK293 CellsSolubilityCell cultureApoptosisMolecular MedicineFemalemedicine.drugJournal of Medicinal Chemistry

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CCDC 113389: Experimental Crystal Structure Determination

2000

Related Article: U.Riese, N.Faza, W.Massa, K.Harms, T.Breyhan, P.Knochel, J.Ensling, V.Ksenofontov, P.Gutlich, K.Dehnicke|1999|Z.Anorg.Allg.Chem.|625|1494|doi:10.1002/(SICI)1521-3749(199909)625:9<1494::AID-ZAAC1494>3.0.CO;2-U

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(mu~3~-Bromo)-tris(mu~3~-tris(dimethylamino)phosphoraneiminato)-tetrabromo-tetra-manganese dichloromethane solvateExperimental 3D Coordinates

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CCDC 113390: Experimental Crystal Structure Determination

2000

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates(mu~3~-Bromo)-tris(mu~3~-tris(dimethylamino)phosphoraneiminato)-tetrabromo-tetra-cobalt dichloromethane solvate

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CCDC 868768: Experimental Crystal Structure Determination

2013

Related Article: Vincent Diemer, Anaïs Berthelot, Jérôme Bayardon, Sylvain Jugé, Frédéric R. Leroux, and Françoise Colobert|2012|J.Org.Chem.|77|6117|doi:10.1021/jo3009098

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameterslambda^5^-Boranyl(2'-bromo-2''6''-dimethoxy-11':3'1''-terphenyl-2-yl)dicyclohexylphosphorane cyclohexane solvateExperimental 3D Coordinates

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CCDC 1053706: Experimental Crystal Structure Determination

2015

Related Article: Jérôme Bayardon , Julie Bernard , Emmanuelle Rémond , Yoann Rousselin , Raluca Malacea-Kabbara , and Sylvain Jugé|2015|Org.Lett.|17|1216|doi:10.1021/acs.orglett.5b00167

Space GroupCrystallographyCrystal SystemCrystal Structurelambda5-Boranyl(dicyclohexyl)(2-(4455-tetramethyl-132-dioxaborolan-2-yl)phenyl)phosphoraneCell ParametersExperimental 3D Coordinates

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CCDC 113392: Experimental Crystal Structure Determination

2000

Space GroupCrystallographyCrystal SystemCrystal Structuretetrakis(mu~3~-Triethylphosphoraneiminato)-tetrabromo-tetra-manganese dichloromethane solvateCell ParametersExperimental 3D Coordinates

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CCDC 1053708: Experimental Crystal Structure Determination

2015

Related Article: Jérôme Bayardon , Julie Bernard , Emmanuelle Rémond , Yoann Rousselin , Raluca Malacea-Kabbara , and Sylvain Jugé|2015|Org.Lett.|17|1216|doi:10.1021/acs.orglett.5b00167

Space GroupCrystallographylambda5-Boranyl(2-(dimesitylboryl)phenyl)ferrocenyl(phenyl)phosphoraneCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates

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Spin Trapping of Carbon-Centered Ferrocenyl Radicals with Nitrosobenzene

2015

In contrast to metal centered 17 valence electron radicals, such as [Mn(CO)5]•, ferrocenium ions [Fe(C5H5)2]+ (1+), [Fe(C5Me5)2]+ (2+), [Fe(C5H5)(C5H4Et)]+ (3+), [Fe(C5H5)(C5H4NHC(O)Me)]+ (4+), and [Fe(C5H5)(C5H4NHC(S)Me)]+ (5+) do not add to nitrosobenzene PhNO to give metal-coordinated stable nitroxyl radicals. In the presence of the strong and oxidatively stable phosphazene base tert-butylimino-tris(dimethylamino)phosphorane, the quite acidic ferrocenium ions 1+–5+ are deprotonated to give a pool of transient and persistent radicals with different deprotonation sites [1–Hx]•–[5–Hx]•. One rather persistent iron-centered radical [4–HN]•, deprotonated at the nitrogen atom, has been detected…

Spin trappingRadicalOrganic ChemistryPhotochemistryPhosphoranelaw.inventionInorganic ChemistryMetalNitrosobenzenechemistry.chemical_compoundDeprotonationchemistrylawvisual_artvisual_art.visual_art_mediumPhysical and Theoretical ChemistryElectron paramagnetic resonancePhosphazeneOrganometallics

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