Search results for "Photodermatosis"
showing 3 items of 3 documents
Inmunohistochemical detection of mastocytes in tissue from patients with actinic prurigo
2015
Background: Actinic prurigo (AP) is a type of photodermatosis, the pathophysiology of which has not been determined. AP has been suggested to be a hypersensitivity reaction to the presence of eosinophils and the local production of IgE. Material and Methods: Descriptive study, using paraffin blocks of tissue that have been diagnosed with AP from the Dermopathology department, Hospital General Dr. Manuel Gea González. In 66 blocks from 63 patients, eosinophils were identified by hematoxylin and eosin staining, and mastocytes were labeled by immunohistochemistry. Three random microphotographs (40x) were used, and cell counts were calculated as the mean count in the 3 microphotographs. Results…
Ketoprofen photodermatosis
2013
Background and aim of the study: The aim of the following review is that of stimulating and highlighting the importance of pharmacovigilance, examining all the data about ketaprofen (a well known NSAD) photodermatosis cases reported in literature, especially those occurred in patients under topical therapy that have been revealed to be adverse reactions. Materials and methods: Analysed data concern studies carried out from 1991 to 2011 among different European countries, in particular at the Swedish University of Lund, Katholieke University of Leuven in Belgium, and in France. All the data arrived through the Italian national pharmacovigilance network. Results: Evidences show that the basic…
Apoptosis and apoptotic pathway in actinic prurigo by immunohistochemistry
2015
Background Actinic prurigo (AP) is an idiopathic photodermatosis, this entity requires exposure to UV-B and -A to develop lesions. Apoptosis is a physiological death program that can be initiated by a permanently active mechanism (extrinsic pathway) or irreparable damage (intrinsic pathway). Material and Methods Descriptive study, the sample size comprised 64 paraffin blocks of tissue with a diagnosis of AP. In H&E-stained slides, the diagnosis of AP was corroborated, and 1-µm-thick sections were processed for immunohistochemistry (IHC). A database was constructed with SPSS version 20, Inc., Chicago, IL, USA, and descriptive statistics were analyzed by X2 test and comparison of means. Resul…