Search results for "Pies"
showing 10 items of 510 documents
Worldwide experience of homozygous familial hypercholesterolaemia:retrospective cohort study
2022
[Background]: Homozygous familial hypercholesterolaemia (HoFH) is a rare inherited disorder resulting in extremely elevated low-density lipoprotein cholesterol levels and premature atherosclerotic cardiovascular disease (ASCVD). Current guidance about its management and prognosis stems from small studies, mostly from high-income countries. The objective of this study was to assess the clinical and genetic characteristics, as well as the impact, of current practice on health outcomes of HoFH patients globally.
Relationship between Meditative Practice and Self-Reported Mindfulness: the MINDSENS Composite Index
2014
Mindfulness has been described as an inherent human capability that can be learned and trained, and its improvement has been associated with better health outcomes in both medicine and psychology. Although the role of practice is central to most mindfulness programs, practice-related improvements in mindfulness skills is not consistently reported and little is known about how the characteristics of meditative practice affect different components of mindfulness. the present study explores the role of practice parameters on self-reported mindfulness skills. A total of 670 voluntary participants with and without previous meditation experience (n = 384 and n = 286, respectively) responded to an…
Intrauterine therapy of goitrous hypothyroidism in a boy with a new compound heterozygous mutation (Y453D and C800R) in the thyroid peroxidase gene. …
2004
We report the results of intrauterine L-thyroxine therapy, and the long-term follow-up in a fetus who presented at 32 weeks' gestation with goitrous hypothyroidism, hyperextension of the neck, and polyhydramnios. Spontaneous delivery was possible and hypothyroidism improved. Molecular analysis revealed a new compound heterozygous mutation (Y453D/C800R) in the TPO gene.
Autosomal Recessive Hypercholesterolemia Long-Term Cardiovascular Outcomes
2017
BACKGROUND Autosomal recessive hypercholesterolemia (ARH) is a rare lipid disorder characterized by premature atherosclerotic cardiovascular disease (ASCVD). There are sparse data for clinical management and cardiovascular outcomes in ARH. OBJECTIVES Evaluation of changes in lipid management, achievement of low-density lipoprotein cholesterol (LDL-C) goals and cardiovascular outcomes in ARH. METHODS Published ARH cases were identified by electronic search. All corresponding authors and physicians known to treat these patients were asked to provide follow-up information, using a standardized protocol. RESULTS We collected data for 52 patients (28 females, 24 males; 31.1 +/- 17.1 years of age…
Timing of quality of life improvements in psoriatic patients treated with different systemic therapies
2019
Psoriasis impacts the quality of life (QoL) by disrupting overall health and social life. Thus, the use of a QoL evaluation item is crucial in assessing a therapeutic regimen. Also, faster improvements in QoL lead to better patient compliance, but very few studies compare psoriasis traditional and biologic therapies timing. To evaluate how much different systemic therapies improve disease severity and QoL, a retrospective analysis was performed on 56 patients. Subjects were administered different drugs and their vital statistics, psoriasis area severity index (PASI) and PSOdisk were collected at baseline and after 30 days. We found a moderate correlation between PASI and PSOdisk score with …
Alternatīvā enerģija un tās izmantošanas iespējas Latvijā
2021
Darba tēma alternatīvā enerģija un tās izmantošanas iespējas Latvijā, tās ekonomiskais izdevīgums, nākotnes perspektīvās un problēmas tās tālākai attīstībai izvēlēta, lai analizētu atjaunojamo resursu izmantošanu, konkrēti Latvijā, tās priekšrocības salīdzinājuma ar citu energoresursu izmantošanas iespējām. Darbā tiek analizēta pašreizējā situācija un tiek sniegti priekšlikumi nākotnes attīstībai. Darba mērķis - Analizēt alternatīvās enerģijas veidus, pielietojumu un ekonomisko efektivitāti Latvijā, veikt salīdzināšanu ar ES un izdarīt secinājumus par alternatīvās enerģijas izmantošanu Latvijā, kā arī sniegt priekšlikumus problēmu risinājumiem. Pētījuma rezultātā tika noskaidroti nozares ek…
In light of the ends. Copyright hysteresis and private copy exception after the British Academy of Songwriters, Composers and Authors (BASCA) and oth…
2015
In British Academy of Songwriters, Composers and Authors (BASCA) and others v Secretary of State for Business, Innovation and Skills, the High Court of Justice in matter of private copy exception provides the twofold prime opportunity to shed light on the state of the art of copyright in the UK and to flesh out the idea of 'legal hysteresis’. I support the reintroduction of the private copy exception, possibly in a less narrow fashion, and I explain the reasons why I am confident that my expectations will be fulfilled.
Laboratory Tests in Crohn’s Disease
2015
Laboratory tests are useful for diagnosing Crohn’s disease, assessing disease activity, identifying complications, and monitoring response to therapy. Their role has been considered limited in the past due to lack of specificity. The introduction of biological therapies in inflammatory bowel disease (IBD) has renewed interest in inflammatory markers, especially C-reactive protein (CRP), given their potential to select responders to these treatments. There are several reasons why laboratory markers have been studied in IBD in the past decades: firstly, to gain an objective measurement of disease activity as symptoms are often subjective; secondly, to avoid invasive (endoscopic) procedures wh…
Bērnu pašapziņas attīstības veicināšana jaunākajā pirmsskolas vecumā
2021
Bakalaura darbs tika izstrādāts par tēmu “Bērnu pašapziņas attīstības veicināšana jaunākajā pirmsskolas vecumā”. Pētījuma mērķis: Noteikt bērnu pašapziņas attīstības veicināšanas paņēmienu efektivitāti jaunākajiem pirmsskolas vecuma bērniem. Hipotēze: Jaunākā pirmsskolas vecuma bērnu pašapziņas attīstība veidosies veiksmīgi, ja darbā ar bērniem tiks izmantotas dažādas metodes un paņēmieni (rotaļas, dzejoļi, pirkstiņu rotaļas), kas veicinās bērnu pašapziņas attīstību. Darbs sastāv no divām daļām – teorētiskās un praktiskās daļas. Teorētiskajā daļā tika pētīta un analizēta pedagoģiskā un psiholoģiskā literatūra par pašapziņas attīstību un tās veicināšanas iespējām jaunākajiem pirmsskolas vecu…
A method to enable the investigation of murine bronchial immune cells, their cytokines and mediators.
2007
Innovative therapies for severe lung diseases (such as allergic and chronic asthma, chronic obstructive pulmonary disease or any type of lung cancer) require a detailed understanding of the cellular and immune processes in the lung. This protocol details a method to obtain the immune cells of the bronchi as well as the cytokines and mediators produced by these cells for further investigation. The broncho-alveolar lavage fluid (BALF) is taken by injecting physiological solution through the tracheal tube into the murine airways and carefully regained by winding up the connected syringe. After centrifugation, the resulting BALF supernatant can be stored for detection of cytokines or other medi…