Search results for "Pinaverium"

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Increased calcium influx is responsible for the sustained mechanical tone in colon from dystrophic (mdx) mice

2001

Abstract Background & Aims: Proximal colon from dystrophic mice develops spontaneous tone increment, but the mechanisms involved in its development have not been investigated. This study examined whether alterations in the properties of cell membrane calcium channels and/or sarcoplasmic reticular (SR) Ca 2+ -adenosine triphosphatase (ATPase) contribute to tone development. Methods: Effects of calcium-free solution, nifedipine, pinaverium (calcium channel blockers), and cyclopiazonic acid (CPA; SR Ca 2+ -ATPase inhibitor) on the contractile activity of colon from mdx and control mice were determined. Results Calcium-free solution abolished spontaneous contractions in both preparations, but d…

Malemedicine.medical_specialtyIndolesNifedipineColonSarcoplasmchemistry.chemical_elementCalciumMuscular DystrophiesCalcium in biologyMicechemistry.chemical_compoundNifedipineInternal medicinemedicineAnimalsHepatologyVoltage-dependent calcium channelCalcium channelGastroenterologyPinaveriumMice Inbred C57BLEndocrinologychemistryMice Inbred mdxCalciumCyclopiazonic acidMuscle Contractionmedicine.drugGastroenterology

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