Search results for "Pines"

Benzodiazepines for catatonic symptoms, stupor, and mutism.

1988

Comparative study of the toxicity of molinate for freshwater organisms.

2003

The diversity of GABAA receptors. Pharmacological and electrophysiological properties of GABAA channel subtypes.

1998

The amino acid gamma-aminobutyric-acid (GABA) prevails in the CNS as an inhibitory neurotransmitter that mediates most of its effects through fast GABA-gated Cl(-)-channels (GABAAR). Molecular biology uncovered the complex subunit architecture of this receptor channel, in which a pentameric assembly derived from five of at least 17 mammalian subunits, grouped in the six classes alpha, beta, gamma, delta, sigma and epsilon, permits a vast number of putative receptor isoforms. The subunit composition of a particular receptor determines the specific effects of allosterical modulators of the GABAARs like benzodiazepines (BZs), barbiturates, steroids, some convulsants, polyvalent cations, and et…

Happy Aged People Are All Alike, While Every Unhappy Aged Person Is Unhappy in Its Own Way

2011

Aging of the world’s population represents one of the most remarkable success stories of medicine and of humankind, but it is also a source of various challenges. The aim of the collaborative cross-cultural European study of adult well being (ESAW) is to frame the concept of aging successfully within a causal model that embraces physical health and functional status, cognitive efficacy, material security, social support resources, and life activity. Within the framework of this project, we show here that the degree of heterogeneity among people who view aging in a positive light is significantly lower than the degree of heterogeneity of those who hold a negative perception of aging. We base…

The Urban Built Environment, Walking and Mental Health Outcomes Among Older Adults: A Pilot Study

2020

The benefits of walking in older age include improved cognitive health (e.g., mental alertness, improved memory functioning) and a reduced risk of stress, depression and dementia. However, research capturing the benefits of walking among older people in real-time as they navigate their world is currently very limited. This study explores cognitive health and well-being outcomes in older people as they walk in their local neighborhood environment. Residents from an independent living facility for older people (mean age 65, n = 11) walked from their home in two dichotomous settings, selected on the basis of significantly different infrastructure, varying levels of noise, traffic and percentag…

A new actor involved in hypothalamic glucose detection : the Transient Receptor Potential Canonical (TRPC) channels

2015

Hyperglycemia is detected and integrated by the mediobasal hypothalamus (MBH) which, in turn, inhibits food intake and triggers insulin secretion. The MBH houses specialized glucose-sensitive (GS) neurons, which directly or indirectly modulate their electrical activity in response to changes in glucose level. In a first study, we hypothesized that indirect detection of glucose by MBH GS neurons involves the secretion of endozepine by astrocytes, a gliotransmitter known to inhibit food intake in response to hyperglycemia. The present work shows that endozepines selectively activate anorexigenic MBH pro-opiomelanotortine (POMC) neurons. In the second study, we show that the direct detection o…

Synthesis and induction of G0–G1 phase arrest with apoptosis of 3,5-dimethyl-6-phenyl-8-(trifluoromethyl)-5,6-dihydropyrazolo[3,4-f][1,2,3,5]tetrazep…

2007

The multistep synthesis of 3,5-dimethyl-6-phenyl-8-(trifluoromethyl)-5,6-dihydropyrazolo[3,4-f][1,2,3,5]tetrazepin-4(3H)-one 15 has been carried out. The compound showed antiproliferative and apoptotic effects against K562, K562-R (imatinib mesilate resistant), HL60 and multidrug resistant (MDR) HL60 cell lines. Compound 15 showed a pro-apoptotic activity against HL60 and K562 resistant cell lines markedly higher than etoposide and busulfan, respectively. Flow cytometry studies carried out on K562 cells allowed to establish that 15 induces G0-G1 phase arrest followed by apoptosis.

The human side of leadership: exploring the relationship between servant leadership, organisational facilitators and happiness at work

2018

Although human resource management (HRM) research has established a significant relationship between leadership styles and different attitudinal outcomes, few studies have considered the important role of organisational facilitators as a more proximal outcome of servant leadership to explain happiness at work (HAW). This paper explores the relationships between servant leadership, organisational facilitators and HAW, based on the leader-member exchange (LMX) and job-demands resources (JD-R) theories. Individual-level analyses from a sample of 189 machine operators revealed that organisational facilitators fully mediate the relationship between servant leadership and HAW. The discussion revi…

Liderazgo femenino y felicidad en el trabajo: el papel mediador del intercambio líder-colaborador

2018

Objetivo: el objetivo de este artículo es examinar el papel del liderazgo femenino en la felicidad en el trabajo de sus colaboradores. Además, se analiza el papel mediador de la relación entre el líder y el colaborador, entendida como el intercambio líder-colaborador (LMX). Método: se ha utilizado la encuesta como método de investigación; se analizaron datos cuantitativos a nivel individual a través de modelos de ecuaciones estructurales. La muestra está compuesta por 292 empleados no directivos del sector hotelero español, para los que se analiza su percepción individual acerca de las variables objeto de estudio. Resultados: los resultados revelan que el liderazgo femenino ejerce un papel …

Freedom and the Pursuit of Happiness

2014

This book is about the relationship between different concepts of freedom and happiness. The book's authors distinguish three concepts for which an empirical measure exists: opportunity to choose (negative freedom), capability to choose (positive freedom), and autonomy to choose (autonomy freedom). They also provide a comprehensive account of the relationship between freedom and well-being by comparing channels through which freedoms affect quality of life. The book also explores whether the different conceptions of freedom complement or replace each other in the determination of the level of well-being. In so doing, the authors make freedoms a tool for policy making and are able t…