Search results for "Piper"
showing 10 items of 632 documents
CCDC 1900203: Experimental Crystal Structure Determination
2019
Related Article: Yathreb Oueslati, Sevgi Kansız, Arto Valkonen, Thameur Sahbani, Necmi Dege, Wajda Smirani|2019|J.Mol.Struct.|1196|499|doi:10.1016/j.molstruc.2019.06.110
CCDC 104621: Experimental Crystal Structure Determination
1999
Related Article: J.Ratilainen, K.Airola, R.Frohlich, M.Nieger, K.Rissanen|1999|Polyhedron|18|2265|doi:10.1016/S0277-5387(99)00117-5
CCDC 1429015: Experimental Crystal Structure Determination
2016
Related Article: Balasubramaniam Arul Prakasam, Anssi Peuronen, Manu Lahtinen, Manickavachagam Muruganandham, Erkki Kolehmainen, Esa Haapaniemi, Mika Sillanpää|2017|Polyhedron|123|453|doi:10.1016/j.poly.2016.11.027
CCDC 1873576: Experimental Crystal Structure Determination
2019
Related Article: Angeliki A. Athanasopoulou, Luca M. Carrella, Eva Rentschler|2019|Dalton Trans.|48|4779|doi:10.1039/C9DT00552H
CCDC 1873578: Experimental Crystal Structure Determination
2019
Related Article: Angeliki A. Athanasopoulou, Luca M. Carrella, Eva Rentschler|2019|Dalton Trans.|48|4779|doi:10.1039/C9DT00552H
CCDC 1957876: Experimental Crystal Structure Determination
2020
Related Article: Maciej Bujak, Dawid Siodłak|2020|Molecules|25|1361|doi:10.3390/molecules25061361
CCDC 1957877: Experimental Crystal Structure Determination
2020
Related Article: Maciej Bujak, Dawid Siodłak|2020|Molecules|25|1361|doi:10.3390/molecules25061361
CCDC 908616: Experimental Crystal Structure Determination
2015
Related Article: Pawel Jewula, Jean-Claude Berthet, Jean-Claude Chambron, Yoann Rousselin, Pierre Thuéry, Michel Meyer|2015|Eur.J.Inorg.Chem.||1529|doi:10.1002/ejic.201403206
Synthesis, radiofluorination and first evaluation of (±)-[18F]MDL 100907 as serotonin 5-HT2Areceptor antagonist for PET
2009
In some psychiatric disorders 5-HT2A receptors play an important role. In order to investigate those in vivo there is an increasing interest in obtaining a metabolically stable, subtype selective and high affinity radioligand for receptor binding studies using positron emission tomography (PET). Combining the excellent in vivo properties of [11C]MDL 100907 for PET imaging of 5-HT2A receptors and the more suitable half-life of fluorine-18, MDL 100907 was radiofluorinated in four steps using 1-(2-bromoethyl)-4-[18F]fluorobenzene as a secondary labelling precursor. The complex reaction required an overall reaction time of 140 min and (±)-[18F]MDL 100907 was obtained with a specific activity of…
Investigating the Molecular Mechanism of H3B-8800: A Splicing Modulator Inducing Preferential Lethality in Spliceosome-Mutant Cancers.
2021
The SF3B1 protein, part of the SF3b complex, recognizes the intron branch point sequence of precursor messenger RNA (pre-mRNA), thus contributing to splicing fidelity. SF3B1 is frequently mutated in cancer and is the target of distinct families of splicing modulators (SMs). Among these, H3B-8800 is of particular interest, as it induces preferential lethality in cancer cells bearing the frequent and highly pathogenic K700E SF3B1 mutation. Despite the potential of H3B-8800 to treat myeloid leukemia and other cancer types hallmarked by SF3B1 mutations, the molecular mechanism underlying its preferential lethality towards spliceosome-mutant cancer cells remains elusive. Here, microsecond-long a…