Search results for "Placement."

Transcranial Magnetic Stimulation Combined With Nicotine Replacement Therapy for Smoking Cessation: A Randomized Controlled Trial.

2015

Abstract Background Further evidence suggests that repetitive Transcranial Magnetic Stimulation (rTMS) is an effective method to reduce tobacco craving among smokers. Hypothesis As relapse is common within a few days after smoking cessation, we hypothesized that combining the anti-craving effects of rTMS with Nicotine replacement therapy (NRT) to attenuate withdrawal symptoms could increase abstinence rates in smokers with severe nicotine dependence who quit smoking. Methods Thirty-seven smokers who failed to quit with the usual treatments were randomly assigned to two treatment groups to receive either active ( n  = 18) or sham ( n  = 19) 1-Hz rTMS of the right dorsolateral prefrontal cort…

Perturbations of symmetric elliptic Hamiltonians of degree four

2006

AbstractIn this paper four-parameter unfoldings Xλ of symmetric elliptic Hamiltonians of degree four are studied. We prove that in a compact region of the period annulus of X0 the displacement function of Xλ is sign equivalent to its principal part, which is given by a family induced by a Chebychev system; and we describe the bifurcation diagram of Xλ in a full neighborhood of the origin in the parameter space, where at most two limit cycles can exist for the corresponding systems.

Diffusion of colloids in one-dimensional light channels

2004

Single-file diffusion (SFD), prevalent in many chemical and biological processes, refers to the one-dimensional motion of interacting particles in pores which are so narrow that the mutual passage of particles is excluded. Since the sequence of particles in such a situation remains unaffected over time t, this leads to strong deviations from normal diffusion, e.g. an increase of the particle mean-square-displacement as the square root of t. We present experimental results of the diffusive behaviour of colloidal particles in one-dimensional channels with varying particle density. The channels are realized by means of a scanning optical tweezers. Based on a new analytical approach (Kollmann 2…

In silico, spectroscopic, and biological insights on annelated pyrrolo[3,2-e]pyrimidines with antiproliferative activity

2013

The in silico COMPARE analysis was performed on 8-[3-(piperidino)propyl]-4,10-dimethyl-9-phenyl-6-(methylsulfanyl)-3,4-dihydropyrimido[1,2-c]pyrrolo[3,2-e]pyrimidin-2(8H)-one, a compound with promising antiproliferative activity, previously synthetized and screened against a panel of 60 human tumor cell lines. The results evidenced that this compound matches the biological properties of Chromomycin A3 and Actinomycin D, known drugs with high DNA binding affinity. Prompted by such results, a thorough spectroscopic investigation of its DNA aqueous solutions was performed, with the aim to verify its DNA-binding properties. DNA groove-binding interaction was assigned by UV-vis spectrophotometri…

Non-porous microparticulate supports in high-performance liquid chromatography (HPLC) of biopolymers — concepts, realization and prospects

1986

A symmetric tangent stiffness approach to cohesive mechanical interfaces in large displacements

2022

The present article proposes a formulation for a cohesive interface element in large displacement conditions. Theoretical and computational aspects, useful for an effective and efficient finite element implementation, are examined in details. A six-node (or higher) isoparametric interface element for two dimensional cohesive fracture propagation problems is developed. The element operators are consistently derived by a variational approach enforced in the current configuration, where a current frame is defined with axes tangential and normal to the middle line of the interface opening displacement gap. Under the constitutive assumption of small value of the modulus of the vector product bet…

Methodology for Structured Data-Path Implementation in VLSI Physical Design: A Case Study

2022

State-of-the-art modern microprocessor and domain-specific accelerator designs are dominated by data-paths composed of regular structures, also known as bit-slices. Random logic placement and routing techniques may not result in an optimal layout for these data-path-dominated designs. As a result, implementation tools such as Cadence’s Innovus include a Structured Data-Path (SDP) feature that allows data-path placement to be completely customized by constraining the placement engine. A relative placement file is used to provide these constraints to the tool. However, the tool neither extracts nor automatically places the regular data-path structures. In other words, the relative placement f…

Extended constrained deformations: a new sculpturing tool

1999

Modelling tools tend to virtual sculpturing, in which a basic object is deformed by user supplied actions. The model we present aims to be generic: whatever the geometric description of the object, we can deform it to satisfy location constraints. Our model deforms the whole space, the image of a point is a blend of deformation functions with a projection matrix which allows the satisfaction of the constraints. The user can define the extent of the deformation (i.e. the part of the object to be deformed), the shape of the deformation function to create profiles and the displacement of the constraint points to be satisfied.

A Case for Raising the Camera: A Driving Simulator Test of Camera-Monitor Systems

2021

Objective This experiment provides a first-of-its-kind driving-simulator study to investigate the feasibility of camera-monitor systems (CMS) with displaced side-mounted cameras in sedans. Background Among the increasing number of studies investigating the replacement of side-mounted rearview mirrors with CMS, the placement of side-mounted cameras has been largely neglected. Moreover, user preferences with respect to camera placement have not been validated in a driving simulator. Past research merely has shown that the vertical camera position can affect distance perception. Method In a driving simulator experiment, we investigated the effects of rearward camera placement on driver accepta…

High Precision Conservative Surface Mesh Generation for Swept Volumes

2015

We present a novel, efficient, and flexible scheme to generate a high-quality mesh that approximates the outer boundary of a swept volume. Our approach comes with two guarantees. First, the approximation is conservative, i.e., the swept volume is enclosed by the generated mesh. Second, the one-sided Hausdorff distance of the generated mesh to the swept volume is upper bounded by a user defined tolerance. Exploiting this tolerance the algorithm generates a mesh that is adapted to the local complexity of the swept volume boundary, keeping the overall output complexity remarkably low. The algorithm is two-phased: the actual sweep and the mesh generation. In the sweeping phase, we introduce a g…