Search results for "Plate"

L'INRA prépare activement l'agriculture de demain

2018

National audience

Precambrian crustal evolution and continental drift

1981

One of the major questions of Precambrian research is whether present-day plate tectonic models can be applied to the evolution of the ancient continental crust or whether the tectonic style suggests a unidirectional and therefore non-uniformitarian development in response to gradual changes in the global thermal regime through time.

Traps N' Clots: NET-Mediated Thrombosis and Related Diseases.

2020

Gut microbiota regulate hepatic von Willebrand factor synthesis and arterial thrombus formation via Toll-like receptor-2.

2016

The symbiotic gut microbiota play pivotal roles in host physiology and the development of cardiovascular diseases, but the microbiota-triggered pattern recognition signaling mechanisms that impact thrombosis are poorly defined. In this article, we show that germ-free (GF) and Toll-like receptor-2 (Tlr2)-deficient mice have reduced thrombus growth after carotid artery injury relative to conventionally raised controls. GF Tlr2-/- and wild-type (WT) mice were indistinguishable, but colonization with microbiota restored a significant difference in thrombus growth between the genotypes. We identify reduced plasma levels of von Willebrand factor (VWF) and reduced VWF synthesis, specifically in he…

The evolving role of platelets in inflammation.

2003

Platelets are small in size and simple in structure. Nevertheless, these anucleate cytoplasts utilize complex molecular systems to regulate a variety of biological functions. Here we review evolutionary paths, traditional roles, and previously unrecognized biological capacities of platelets that interface thrombosis with inflammation and potentially identify new roles in inflammatory diseases.

Serum brain-derived neurotrophic factor and platelet activation evaluated by soluble P-selectin and soluble CD-40-ligand in patients with acute myoca…

2009

Little is known about the role of neurotrophins (NT) under adult vascular homeostasis in normal and pathological conditions. The NT family, including nerve growth factor and brain-derived neurotrophic factor (BDNF) are expressed in atherosclerotic vessels. Previous studies demonstrated that plasma BDNF levels were increased in the coronary circulation in patients with unstable angina. However, the role of BDNF during the onset and evolution of unstable angina remains to be elucidated. The objective of this study was to evaluate the relationship between BDNF, functional parameters and biological markers associated with inflammatory processes and platelet activation. BDNF serum levels were as…

Tectonic evolution of the Sierra Maestra Mountains, SE Cuba, during Tertiary times: From arc-continent collision to transform motion

2008

Abstract A structural study was carried out along the southern Sierra Maestra mountain range, SE Cuba. This was aimed to monitor the effects of Paleogene island arc formation and collision due to convergence of the Caribbean and North American plates and subsequent Neogene disruption of the arc by initiation of the North Caribbean Transform Fault. In the Sierra Maestra two different and unrelated volcanic arcs are exposed, one of Cretaceous age (pre-Maastrichtian) and the other of Paleogene age, the latter forming the main expression of the mountain range. The volcanic arcs are overlain by Middle–Upper Eocene siliciclastic, carbonate and terrigenous rocks. Six distinct phases of deformation…

Block Based Deconvolution Algorithm Using Spline Wavelet Packets

2010

This paper presents robust algorithms to deconvolve discrete noised signals and images. The idea behind the algorithms is to solve the convolution equation separately in different frequency bands. This is achieved by using spline wavelet packets. The solutions are derived as linear combinations of the wavelet packets that minimize some parameterized quadratic functionals. Parameters choice, which is performed automatically, determines the trade-off between the solution regularity and the initial data approximation. This technique, which id called Spline Harmonic Analysis, provides a unified computational scheme for the design of orthonormal spline wavelet packets, fast implementation of the…

A bacterial metabolite, trimethylamine N-oxide, disrupts the hemostasis balance in human primary endothelial cells but no coagulopathy in mice

2019

: The gut microbial metabolite, trimethylamine N-oxide (TMAO), was previously reported to induce platelet hypersensitivity, which leads to thrombotic risk. However, the molecular mechanism underlying the effects of TMAO on endothelial cells (EC), which is the primary vessel wall contact with the lumen, remains unclear. Here, we investigated the impact of TMAO on procoagulant activity (PCA) in EC and mice, for a possible link between microbiota and coagulation. To test the PCA of TMAO in EC, we performed one-stage clotting assays and converted into PCA. Antitissue factor (TF) antibody was used to test the TF role in PCA. Quantitative PCR was performed to measure the TF, thrombomodulin, IL-6,…

Dose Responsive Effects of Subcutaneous Pentosan Polysulfate Injection in Mucopolysaccharidosis Type VI Rats and Comparison to Oral Treatment

2014

Background We previously demonstrated the benefits of daily, oral pentosan polysulfate (PPS) treatment in a rat model of mucopolysaccharidosis (MPS) type VI. Herein we compare these effects to once weekly, subcutaneous (s.c.) injection. The bioavailability of injected PPS is greater than oral, suggesting better delivery to difficult tissues such as bone and cartilage. Injected PPS also effectively treats osteoarthritis in animals, and has shown success in osteoarthritis patients. Methodology/principal findings One-month-old MPS VI rats were given once weekly s.c. injections of PPS (1, 2 and 4 mg/kg, human equivalent dose (HED)), or daily oral PPS (4 mg/kg HED) for 6 months. Serum inflammato…