Search results for "Plate"

Comparison of GTR, T-PRF and open-flap debridement in the treatment of intrabony defects with endo-perio lesions : a randomized controlled trial

2019

Background Titanium- prepared platelet rich fibrin (T-PRF) is an autologous hemo-component with a high concentration of platelets that also incorporates leukocytes, and growth factors into the dense fibrin matrix and can be used as a healing biomaterial. This study assesses the adjunctive use of T-PRF in intrabony defects (IBDs) with open flap debridement (OFD) in comparison with guided tissue regeneration (GTR) as a gold standard and OFD alone as a control. Material and Methods A total of 45 patients (15 per group) were randomized as either T-PRF (test group), GTR (test group), or OFD alone (control group) sites. Probing depth (PD), clinical attachment level (CAL), and IBD were recorded. T…

Magnetic Resonance Imaging and Ultrasound Evaluation after Breast Autologous Fat Grafting Combined with Platelet-Rich Plasma

2014

LAAE-14, a new in vitro inhibitor of intracellular calcium mobilization, modulates acute and chronic inflammation.

2003

Abstract A new lipidic acid-amido ether derivative (LAAE-14) able to reduce dose-dependently the calcium increases mediated either by calcium ionophore ionomycin, by the endoplasmic reticular Ca 2+ -ATPase inhibitor thapsigargin, or by the chemotactic tripeptide N -formyl- l -methionyl- l -leucyl- l -phenylalanine (fMLP), in human neutrophils as well as in murine peritoneal macrophages, but not ATP, has been evaluated as a potential anti-inflammatory drug. This compound attenuated leukocyte activation by means of its inhibitory effect on the respiratory burst elicited in both types of cells by 12- O -tetradecanoyl phorbol 13-acetate, by inhibition of the degranulation process induced by cyt…

Pannello precompresso di vetromattoni assemblati a secco per la realizzazione di involucri traslucidi

2012

L’invenzione riguarda la realizzazione di un pannello di vetromattoni montati “a secco” -da impiegare per la realizzazione di involucri edilizi traslucidi anche nel caso di edifici alti- che è in grado di rispondere adeguatamente alle sollecitazioni orizzontali (quali quelle dovute a vento e sisma) grazie all’applicazione della tecnica della precompressione mondirezionale. Per offrire una risposta ai limiti imposti dalla tecnica di assemblaggio tradizionale dei vetromattoni (“ad umido”), l’applicazione della precompressione consente, infatti, di dare ai pannelli preassemblati “a secco” una rigidezza adeguata anche in direzione normale al loro piano di posa, sfruttando le buone caratteristic…

Experimental and Numerical Simulations of Flow and Heat Transfer in Heat Exchanger Elements Using Liquid Crystal Thermography

2004

Experimental and numerical investigation of heat transfer and fluid flow were conducted for classic heat exchanger elements (flat plate with fin-tubes in-line, staggered and with vortex generators) and corrugated-undulated ducts under transitional and weakly turbulent conditions. The dependence of average heat transfer and pressure drop on Reynolds number and geometrical parameters was investigated. Distributions of local heat transfer coefficient were obtained by using liquid crystal thermography and surface-averaged values were computed. Three-dimensional numerical simulations were conducted by a finite-volume method using a low-Reynolds number k-e model under the assumption of fully deve…

A bacterial metabolite, trimethylamine N-oxide, disrupts the hemostasis balance in human primary endothelial cells but no coagulopathy in mice

2019

: The gut microbial metabolite, trimethylamine N-oxide (TMAO), was previously reported to induce platelet hypersensitivity, which leads to thrombotic risk. However, the molecular mechanism underlying the effects of TMAO on endothelial cells (EC), which is the primary vessel wall contact with the lumen, remains unclear. Here, we investigated the impact of TMAO on procoagulant activity (PCA) in EC and mice, for a possible link between microbiota and coagulation. To test the PCA of TMAO in EC, we performed one-stage clotting assays and converted into PCA. Antitissue factor (TF) antibody was used to test the TF role in PCA. Quantitative PCR was performed to measure the TF, thrombomodulin, IL-6,…

A critical evaluation of caplacizumab for the treatment of acquired thrombotic thrombocytopenic purpura

2020

Introduction: Acquired thrombotic thrombocytopenic purpura (aTTP) is a thrombotic microangiopathy caused by inhibitory autoantibodies against ADAMTS13 protein. Until recently, the combination of plasma exchange (PEX) and immunosuppression has been the standard front-line treatment in this disorder. However, aTTP-related mortality, refractoriness, and relapse are still a matter of concern. Areas covered: The better understanding of the pathophysiological mechanisms of aTTP has allowed substantial improvements in the diagnosis and treatment of this disease. Recently, the novel anti-VWF nanobody caplacizumab has been approved for acute episodes of aTTP. Caplacizumab is capable to block the adh…

COVID-19 as a Potential Trigger for Immune Thrombotic Thrombocytopenic Purpura and Reason for an Unusual Treatment: A Case Report

2021

AbstractImmune thrombotic thrombocytopenic purpura (iTTP) is a rare autoimmune disorder characterized by severely reduced activity of the von Willebrand factor (VWF)-cleaving protease ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) due to autoantibodies. This leads to the development of pathogenic multimers of VWF, causing a thrombotic microangiopathy with decreased number of platelets, hemolysis, and life-threatening tissue ischemia of mostly brain, heart, and kidneys. Standard treatment of iTTP involves daily plasma exchange to remove ultra large multimers of VWF, inhibitors, substituting ADAMTS13, and the accompaniment of an immunosuppressive …

Spline Algorithms for Deconvolution and Inversion of Heat Equation

2014

In this chapter, we present algorithms based on Tikhonov regularization for solving two related problems: deconvolution and inversion of heat equation. The algorithms, which utilize the SHA technique, provide explicit solutions to the problems in one and two dimensions.

Cardiovascular effects of air pollution

2017

Air pollution is composed of particulate matter (PM) and gaseous pollutants, such as nitrogen dioxide and ozone. PM is classified according to size into coarse particles (PM 10), fine particles (PM 2.5) and ultrafine particles. We aim to provide an original review of the scientific evidence from epidemiological and experimental studies examining the cardiovascular effects of outdoor air pollution. Pooled epidemiological studies reported that a 10 μg/m 3 increase in long-term exposure to PM 2.5 was associated with an 11% increase in cardiovascular mortality. Increased cardiovascular mortality was also related to long-term and short-term exposure to nitrogen dioxide. Exposure to air pollution…