Search results for "Platelets"

Consensus document on intermittent claudication from the Central European Vascular Forum 1st edition - Abano Terme (Italy) - May 2005 2nd revision - …

2008

What Can Proteomics Tell Us About Platelets?

2014

More than 130 years ago, it was recognized that platelets are key mediators of hemostasis. Nowadays, it is established that platelets participate in additional physiological processes and contribute to the genesis and progression of cardiovascular diseases. Recent data indicate that the platelet proteome, defined as the complete set of expressed proteins, comprises >5000 proteins and is highly similar between different healthy individuals. Owing to their anucleate nature, platelets have limited protein synthesis. By implication, in patients experiencing platelet disorders, platelet (dys)function is almost completely attributable to alterations in protein expression and dynamic difference…

Platelet function testing in pigs using the Multiplate® Analyzer.

2019

PLOS ONE 14(8), e0222010 (2019). doi:10.1371/journal.pone.0222010

Synthesis and processing of nanocrystalline tungsten carbide: Towards cemented carbides with optimal mechanical properties

2011

Abstract Nanocrystalline tungsten carbide has been obtained by reduction/carburization at low temperature from precursors obtained by freeze-drying of aqueous solutions. Nanocrystalline WC powders with a adequate content of carbon were mixed with submicrometric Cobalt powder (12 wt.%), obtained by same synthesis method, and sintered in vacuum furnace. The cemented carbides fabricated from experimental powders were compared with both commercial ultrafine and nanocrystalline WC-12Co mixtures consolidated by the same route. The synthesised powders were characterized by X-ray powder diffraction, elemental analysis and scanning and high resolution transmission electron microscopy. On the other h…

The Essential Thrombocythemia in 2020: What We Know and Where We Still Have to Dig Deep

2020

The Essential Thrombocythemia is a Chronic Philadelphia-negative Myeloproliferative Neoplasm characterized by a survival curve that is only slightly worse than that of age- and sex-adjusted healthy population. The criteria for diagnosis were reviewed in 2016 by WHO. The incidence varies from 0.2 to 2.5:100 000 people per year, with a prevalence of 38 to 57 cases per 100 000 people. The main characteristics of ET are the marked thrombocytosis and the high frequency of thrombosis. The spectrum of symptoms is quite wide, but fatigue results to be the most frequent. Thrombosis is frequently observed, often occurring before or at the time of diagnosis. The classification of thrombotic risk has …

Insights in ChAdOx1 nCoV-19 vaccine-induced immune thrombotic thrombocytopenia

2021

Abstract SARS-CoV-2 vaccine ChAdOx1 nCoV-19 (AstraZeneca) causes a thromboembolic complication termed vaccine-induced immune thrombotic thrombocytopenia (VITT). Using biophysical techniques, mouse models, and analysis of VITT patient samples, we identified determinants of this vaccine-induced adverse reaction. Super-resolution microscopy visualized vaccine components forming antigenic complexes with platelet factor 4 (PF4) on platelet surfaces to which anti-PF4 antibodies obtained from VITT patients bound. PF4/vaccine complex formation was charge-driven and increased by addition of DNA. Proteomics identified substantial amounts of virus production-derived T-REx HEK293 proteins in the ethyle…

Effect of graphene nanoplatelets on the photo-oxidative behavior of PP based nanocomposites

2018

The photo-oxidation behavior of polymer nanocomposites depends not only on the photo-oxidation behavior of the matrix, but also on the chemical composition and on the physical properties of the nanoparticles and on the possible interactions between the two phases. Graphene nanoplatelets (GnP) are short stacks of individual layers of graphite that, even at low contents, strongly affects many properties of the thermoplastic matrix. Indeed, by GnP adding, also at low filler concentration (< 5 wt.%), the mechanical, heat-resistance, thermal and electrical properties of the polymer matrix can be surprisingly modified. Of course, the effects of these nanoparticles on the properties of the poly…

Polypropylene/graphene nanoplatelets nanocomposites subjected to elongational flow

2018

In this work the effect of the presence of graphene nanoplatelets (GnP) on the morphology and mechanical properties of polypropylene/GnP nanocomposites has been investigated when these polymer systems are subjected to non-isothermal elongational flow in a melt spinning operation. The presence of the GnP magnifies the effect of the elongational flow. Indeed, the elastic modulus and the tensile strength increases with the orientation more than that observed for the pure matrix.

Photo-oxidative behavior of PP/GnP nanocomposites

2018

In this work the photo-oxidative behavior of neat polypropylene (PP) and PP based nanocomposites incorporating graphene nanoplatelets (GnP) was studied. In particular, the influence of the amount of incorporated GnP was evaluated. The photo-oxidation has been followed by monitoring the change of the rheological, mechanical and spectroscopic properties upon artificial exposure to UV-B light. The results revealed that the presence of GnP reduced the rate of photooxidation of the PP matrix and, in the investigated composition range, the photo-stabilizing action improved with increasing the GnP content.

Platelet changes in patients with hepatitis C virus-related liver cirrhosis after directly acting antiviral therapy

2017

Background and Purpose of the study:Thrombocytopenia is the most common haematological abnormality in patients with Liver Cirrhosis and it is caused by multiple factors. This study evaluated platelets (PLT) count changes in patients with HCV related LC after DAAs therapy. Materials and Methods: We enrolled 83 patients with LC. In all patients were evaluated liver function tests and PLT count at baseline (BL), at end of therapy (ET) and three months post treatment (PostT), Elastography and ultrasound (US) at BL, and US at PostT. LC diagnosis was histological in 13 patients, in 71 with liver stiffness >12 kPa. All patients were SVR (58 patients had DAAs therapy without, 25 with Ribavirin).…