Search results for "Plot"

Is the Kidscreen-27 a valid measure of health-related quality of life in 10-year-old Norwegian children?

2015

The aim of this study was to investigate the reliability and validity of the Norwegian Kidscreen-27 questionnaire, a measure of generic health-related quality of life, in 10 year-old children. The Kidscreen-27 consists of five domains and was validated in a sample of 56 school children (29 boys). The children completed the questionnaire at three different time points during two consecutive school days. For convergent validity, the study was powered to detect a statistically significant correlation coefficient of 0.4. Cronbach's alpha values ranged from 0.73 to 0.83. Floor effects were all zero and ceiling effects ranged from 1.7% to 23.7%. Intraclass correlation values over time ranged from…

A systematic comparison of kinetic modelling methods generating parametric maps for [11C]-(R)-PK11195

2006

[(11)C]-(R)-PK11195 is presently the most widely used radiotracer for the monitoring of microglia activity in the central nervous system (CNS). Microglia, the resident immune cells of the brain, play a critical role in acute and chronic diseases of the central nervous system and in host defence against neoplasia. The purpose of this investigation was to evaluate the reliability and sensitivity of five kinetic modelling methods for the formation of parametric maps from dynamic [(11)C]-(R)-PK11195 studies. The methods we tested were the simplified reference tissue model (SRTM), basis pursuit, a simple target-to-reference ratio, the Logan plot and a wavelet based Logan plot. For the reliabilit…

Momentum dependence of the decay η→π+π−π0

1998

Abstract The π 0 momentum dependence of the decay η → π + π − π 0 has been measured with the Crystal Barrel detector. The analysis is based on 3230 events. The results of this independent measurement are compared to new chiral perturbation theory calculations and previous measurements.

El territorio inmediato de Kelin en época ibérica (siglos IV-III a.C.): estrategias productivas y poblacionales

2009

Kelin (Caudete de las Fuentes, València) es un oppidum ibérico con una ocupación entre finales del siglo VII hasta el I a.C., que se consolida como lugar central ya a finales del V a.C. Kelin organizó su territorio en base a un patrón de asentamiento jerarquizado que incluía asentamientos de rango superior (oppida), granjas, caseríos y establecimientos rurales, atalayas fortificadas y lugares cultuales como necrópolis, cuevas y santuarios. Nuestra intención es analizar el entorno del yacimiento para aproximarnos a las estrategias económicas y poblacionales que se desarrollaron. El ejemplo que presentamos combina el análisis mediante SIG de las áreas de captación con la información arqueológ…

Die Verwandlung der senecanischen Tragödie in Marc-Antoine Murets “Julius Caesar” und Jacques Grévins “César”

1994

In 1547 Marc-Antoine Muret wroteJulius Caesar, the first tragedy by a French author with an exclusively historical plot. While imitating the dramatic structure of Seneca's tragedies, he fundamentally changed the nature of the tragic conflict, transferring it from the character of the tragic hero to the clash of two basically positive principles, monarchy and Republican liberty. Muret's Caesar does not plan a revengeful crime as the Senecan heroes did; he is rather the successful statesman, ready to die after having won the victory over the entire world, and his apotheosis is soon fulfilled by the gods. On the other side are the Republican heroes Brutus and Cassius who succeed in killing the…

Comparison of some dispersion-corrected and traditional functionals as applied to peptides and conformations of cyclohexane derivatives.

2012

We compare the energetic and structural properties of fully optimized α-helical and antiparallel β-sheet polyalanines and the energetic differences between axial and equatorial conformations of three cyclohexane derivatives (methyl, fluoro, and chloro) as calculated using several functionals designed to treat dispersion (B97-D, ωB97x-D, M06, M06L, and M06-2X) with other traditional functionals not specifically parametrized to treat dispersion (B3LYP, X3LYP, and PBE1PBE) and with experimental results. Those functionals developed to treat dispersion significantly overestimate interaction enthalpies of folding for the α-helix and predict unreasonable structures that contain Ramachandran φ and …

A comprehensive study of polymorphisms in the ABCB1, ABCC2, ABCG2, NR1I2 genes and lymphoma risk.

2011

Owing to their role in controlling the efflux of toxic compounds, transporters are central players in the process of detoxification and elimination of xenobiotics, which in turn is related to cancer risk. Among these transporters, ATP-binding cassette B1/multidrug resistance 1 (ABCB1/MDR1), ABCC2/multidrug resistance protein 2 (MRP2) and ABCG2/breast cancer resistance protein (BCRP) affect susceptibility to many hematopoietic malignancies. The maintenance of regulated expression of these transporters is governed through the activation of intracellular "xenosensors" like the nuclear receptor 1I2/pregnane X receptor (NR1I2/PXR). SNPs in genes encoding these regulators have also been implicate…

Using Y-chromosome capture enrichment to resolve haplogroup H2 shows new evidence for a two-path Neolithic expansion to Western Europe

2021

Uniparentally-inherited markers on mitochondrial DNA (mtDNA) and the non-recombining regions of the Y chromosome (NRY), have been used for the past 30 years to investigate the history of humans from a maternal and paternal perspective. Researchers have preferred mtDNA due to its abundance in the cells, and comparatively high substitution rate. Conversely, the NRY is less susceptible to back mutations and saturation, and is potentially more informative than mtDNA owing to its longer sequence length. However, due to comparatively poor NRY coverage via shotgun sequencing, and the relatively low and biased representation of Y-chromosome variants on capture assays such as the 1240 k, ancient DNA…

Proyecto de creación de un grupo de propietarios de agrios

1980

New Author Guidelines for Displaying Data and Reporting Data Analysis and Statistical Methods in Experimental Biology

2019

The American Society for Pharmacology and Experimental Therapeutics has revised the Instructions to Authors for Drug Metabolism and Disposition, Journal of Pharmacology and Experimental Therapeutics, and Molecular Pharmacology These revisions relate to data analysis (including statistical analysis) and reporting but do not tell investigators how to design and perform their experiments. Their overall focus is on greater granularity in the description of what has been done and found. Key recommendations include the need to differentiate between preplanned, hypothesis-testing, and exploratory experiments or studies; explanations of whether key elements of study design, such as sample size and …