Search results for "Plunc"
showing 3 items of 3 documents
Plasma PLTP (phospholipid-transfer protein): an emerging role in ‘reverse lipopolysaccharide transport’ and innate immunity
2011
Plasma PLTP (phospholipid-transfer protein) is a member of the lipid transfer/LBP [LPS (lipopolysaccharide)-binding protein] family, which constitutes a superfamily of genes together with the short and long PLUNC (palate, lung and nasal epithelium clone) proteins. Although PLTP was studied initially for its involvement in the metabolism of HDL (high-density lipoproteins) and reverse cholesterol transport (i.e. the metabolic pathway through which cholesterol excess can be transported from peripheral tissues back to the liver for excretion in the bile), it displays a number of additional biological properties. In particular, PLTP can modulate the lipoprotein association and metabolism of LPS …
Proteomic characterization of the mucosal pellicle formed in vitro on a cellular model of oral epithelium
2020
The oral mucosal pellicle is a thin lubricating layer generated by the binding of saliva proteins on epithelial oral cells. The protein composition of this biological structure has been to date studied by targeted analyses of specific salivary proteins. In order to perform a more exhaustive proteome characterization of pellicles, we used TR146 cells expressing or not the transmembrane mucin MUC1 and generated pellicles by incubation with human saliva and washing to remove unbound proteins. A suitable method was established for the in vitro isolation of the mucosal pellicle by "shaving" it from the cells using trypsin. The extracts, the washing solutions and the saliva used to constitute the…
Radioterapia adaptada a los movimientos fisiológicos. Incertidumbres asociadas
2015
Los movimientos del paciente, de órganos y tumores son la nueva frontera tecnológica para los tratamientos de radioterapia. Con el creciente uso de la radioterapia externa altamente conformada, se ha logrado reducir el tumor mediante la reducción de las incertidumbres geométricas durante el curso del tratamiento. Contabilizando las incertidumbres en la intrafracción (dentro de la misma fracción de tratamiento) e interfracción (entre dos fracciones distintas, generalmente consecutivas, i.e. dos días de tratamiento distintos) asociadas al posicionamiento del paciente, movimientos tumorales (incluidos los movimientos de pulmón e hígado con la respiración) y los cambios entre las 5 y 7 semanas …