Search results for "Pori"
showing 10 items of 761 documents
Vaporization characteristics of 1-propanol droplets at high temperatures
2011
International audience; The gasification of a droplet via vaporization is one of the main processes in combustion systems, namely diesel and propulsion engines. In these combustion systems, always the liquid fuel is atomized as a cloud of droplets in the chamber, which then vaporizes, and mixes with the oxidant and burns to release heat. Therefore, to afford a better knowledge especially in modelling complex spray flows and mixture formation issues, the study of the droplet vaporization which involves mass, heat and momentum transfer processes is really vital. Alcohol has been chosen for this particular study due to its potential as an alternative fuel to the current conventional hydrocarbo…
Salaviinarinkien toimintaympäristöt Helsingissä 1770-1787
2017
Tutkielma käsittelee salaviinarinkien toimintaympäristöjä vuosien 1770–1787 Helsingissä. Aikakautta määritti Kustaa III:n ailahtelevainen alkoholipolitiikka (1772–1787), jonka vuoksi arkinen viinanpoltto muuttui laittomaksi toiminnaksi. Samalla kriminalisoitiin muun muassa laittomasti poltetun viinan hallussapito ja myynti. Lisäksi alkoholinkäyttöä rajoittivat vanhemmat lait, jotka tähtäsivät ylenjuonnin aiheuttamien järjestyshäiriöiden siistimiseen pois julkisesta tilasta. Varhaismodernilla ajalla alkoholin käyttö oli runsasta ja kuului kiinteänä osana arkeen sekä juhlaan. Lainsäädännön ristiriita tapakulttuurin kanssa muodosti julkisten salaisuuksien kulttuurin, jossa rikollista toimintaa…
Cytoplasmic Parvovirus Capsids Recruit Importin Beta for Nuclear Delivery
2019
Parvoviruses are an important platform for gene and cancer therapy. Their cell entry and the following steps, including nuclear import, are inefficient, limiting their use in therapeutic applications. Two models exist on parvoviral nuclear entry: the classical import of the viral capsid using nuclear transport receptors of the importin (karyopherin) family or the direct attachment of the capsid to the nuclear pore complex leading to the local disintegration of the nuclear envelope. Here, by laser scanning confocal microscopy and in situ proximity ligation analyses combined with coimmunoprecipitation, we show that infection requires importin β-mediated access to the nuclear pore complex and …
Failure to differentiate Cryptosporidium parvum from C. meleagridis based on PCR amplification of eight DNA sequences.
1998
ABSTRACT In order to determine the specificities of PCR-based assays used for detecting Cryptosporidium parvum DNA, eight pairs of previously described PCR primers targeting six distinct regions of the Cryptosporidium genome were evaluated for the detection of C. parvum , the agent of human cryptosporidiosis, and C. muris , C. baileyi , and C. meleagridis , three Cryptosporidium species that infect birds or mammals but are not considered to be human pathogens. The four Cryptosporidium species were divided into two groups: C. parvum and C. meleagridis , which gave the same-sized fragments with all the reactions, and C. muris and C. baileyi , which gave positive results with primer pairs targ…
Bruton tyrosine kinase-like protein, BtkSD, is present in the marine sponge Suberites domuncula.
2003
Sponges, the simplest and most ancient phylum of Metazoa, encode in their genome complex and highly sophisticated proteins that evolved together with multicellularity and are found only in metazoan animals. We report here the finding of a Bruton tyrosine kinase (BTK)-like protein in the marine sponge Suberites domuncula (Demospongiae). The nucleotide sequence of one sponge cDNA predicts a 700-aa-long protein, which contains all of the characteristic domains for the Tec family of protein tyrosine kinases (PTKs). The highest homology (38% identity, 55% overall similarity) was found with human BTK and TEC PTKs. Sponge PTK was therefore named BtkSD. Human BTK is involved in the maturation of B …
A galectin links the aggregation factor to cells in the sponge (Geodia cydonium) system.
1996
The cDNA for the full-length lectin from the marine sponge Geodia cydonium was cloned. Analysis of the deduced aa sequence revealed that this lectin belongs to the group of galectins. The full-length galectin, which was obtained also in a recombinant form, has an M(r) of 20,877; in the processed form it is a 15 kDa polypeptide. The enriched aggregation factor from G.cydonium also was determined to contain, besides minimal amounts of the galectin, a 140 kDa polypeptide which is involved in cell-cell adhesion. Monoclonal antibodies have been raised against this protein; Fab' fragments prepared from them abolished cell-cell reaggregation. Cell reaggregation experiments revealed that the aggreg…
Early evolution of metazoan serine/threonine and tyrosine kinases: identification of selected kinases in marine sponges.
1997
The phylum Porifera (sponges) was the first to diverge from the common ancestor of the Metazoa. In this study, six cDNAs coding for protein-serine/threonine kinases (PS/TKs) are presented; they have been isolated from libraries obtained from the demosponges Geodia cydonium and Suberites domuncula and from the calcareous sponge Sycon raphanus. Sequence alignments of the catalytic domains revealed that two major families of PS/TK, the "conventional" (Ca(2+)-dependent) protein kinase C (PKC), the cPKC subfamily, as well as the "novel" (Ca(2+)-independent) PKC (nPKC), form two separate clusters. In each cluster, the sequence from S. raphanus diverges first. To approach the question about the or…
Histone Deacetylase Inhibitors
2020
Histone deacetylases (HDACs) are key components of the epigenetic machinery controlling gene expression. They are involved in chromatin remodeling events via post-translational histone modifications but may also act on nonhistone proteins, influencing many fundamental cellular processes. Due to the key involvement of HDACs in serious human pathologies, including cancer, HDAC inhibitors (HDACis) have received increased attention in recent years. It is known that marine invertebrates produce significant amounts of secondary metabolites showing active pharmacological properties and an extensive spectrum of biomedical applications. Some of these compounds possess HDACi properties.
Modificētus mālus saturošu materiālu antimikrobiālā iedarbība
2017
Mikroorganismu attīstība uz dažādiem materiāliem izsenis ir ietekmējusi cilvēka dzīves kvalitāti. Vieni no biežāk būvmateriālos sastopamajiem mikroorganismiem ir sēnes. Pētījuma mērķis bija noskaidrot modificēta māla un tā piedevu ietekmi uz mikroskopisko sēņu attīstību uz dažādiem būvniecības materiāliem. Pētīti 12 ar dažādu metālu joniem modificētu māla pulvera paraugu, kas 0,2% un 2% koncentrācijas iestrādāti iesala agara barotnēs, ietekme uz Cladosporium herbarum un Alternaria alternata augšanu. Tika pētīta sēņu attīstība uz dažāda veida krāsām, ar lineļļu apstrādātiem kokmateriāliem un saplākšņa materiāliem. Ietekme tika novērota sešiem no divpadsmit māla pulvera paraugiem Alternaria a…
Ipotesi sul valore filosofico di “pontano igualmente” nel canto IV, 26 del Paradiso di Dante
2010
Analisi storico-filosofica di quei luoghi nel "Paradiso" di Dante in cui si manifesta la crisi della discorsività e della logica della proporzione