Search results for "Pose"
showing 10 items of 1189 documents
How many sites of action for endocannabinoids to control energy metabolism?
2006
The promising results obtained by clinical trials using Rimonabant to tackle visceral obesity and related disorders recently promoted a remarkable impulse to carry out detailed investigations into the mechanisms of action of endocannabinoids in regulating food intake and energy metabolism. The endocannabinoid system has been known for many years to play an important role in the modulation of the neuronal pathways mediating the rewarding properties of food. However, in the last few years, with the advanced understanding of the crucial role of the hypothalamic neuronal network in the regulation of appetite, several studies have also directed attention to the orexigenic role of the endocannabi…
Nutritional supplementation with trans-10, cis-12-conjugated linoleic acid induces inflammation of white adipose tissue.
2006
Conjugated linoleic acids (CLAs) are conjugated dienoic isomers of linoleic acid. Many people supplement their diets with CLAs to attempt weight loss, and the trans-10,cis-12 isomer (t10,c12-CLA) of CLA reduces adiposity in animal models and humans. However, CLA treatment in mice causes insulin resistance that has been attributed to the lipoatrophic state, which is associated with hyperinsulinemia and hepatic steatosis. Here, we investigated the effect of t10,c12-CLA on adipose tissue inflammation, another factor promoting insulin resistance. We confirmed that t10,c12-CLA daily gavage performed in mice reduces white adipose tissue (WAT) mass and adiponectin and leptin serum levels and provo…
Molecular dynamics, dynamic site mapping, and highthroughput virtual screening on leptin and the Ob receptor as anti-obesity target.
2014
Body weight control is a mechanism finely regulated by several hormonal, metabolic, and nervous pathways. The leptin receptor (Ob-R) is crucial for energy homeostasis and regulation of food uptake. Leptin is a 16 kDa hormone that is mainly secreted by fat cells into the bloodstream, and under normal circumstances, circulating levels are proportionate to the fat body mass. Sensing of elevated leptin levels by the hypothalamic neurocircutry activates a negative feedback loop resulting in reduced food intake and increased energy expenditure. Decreased concentrations lead to opposite effects. Therefore rational design of leptin agonists constitute an appealing challenge in the battle against ob…
Obesity, type 2 diabetes and risk of digestive cancer.
2010
The frequency of obesity has been increasing worldwide for 20 years. Many epidemiological studies support a correlation between obesity and increased risk of cancer, particularly digestive cancers in both genders, and gynaecological cancer in women. Currently, about 5% of cancers could be directly related to overweight. Carcinogenesis mechanisms induced by obesity involve insulin resistance, adipokine and angiogenic factor secretions, and inflammation. Experimental and clinical evidence suggest that insulin resistance plays a major role in carcinogenesis. Insulin and non-protein banded IGF-1, whose levels are increased in type 2 diabetes, stimulate cellular growth and inhibit apoptosis. Abn…
Bisphenol-A impairs insulin action and up-regulates inflammatory pathways in human subcutaneous adipocytes and 3T3-L1 cells.
2013
Current evidence indicates that chemical pollutants may interfere with the homeostatic control of nutrient metabolism, thereby contributing to the increased prevalence of metabolic disorders. Bisphenol-A (BPA) is a lipophilic compound contained in plastic which is considered a candidate for impairing energy and glucose metabolism. We have investigated the impact of low doses of BPA on adipocyte metabolic functions. Human adipocytes derived from subcutaneous adipose tissue and differentiated 3T3-L1 cells were incubated with BPA, in order to evaluate the effect on glucose utilization, insulin sensitivity and cytokine secretion. Treatment with 1 nM BPA significantly inhibited insulin-stimulate…
Towards Teaching English for Pharmaceutical Purposes: An Attempt at a Description of Key Vocabulary and Phraseology in Clinical Trial Protocols and E…
2014
With the exception of medical schools or medical universities, English for Pharmaceutical Purposes is rarely taught as a specialist language course or ESP module at the university-level (e.g. designed specifically for training translators of specialist texts). This may be caused by, among other factors, the lack of comprehensive description of vocabulary and phraseology used across different pharmaceutical text types and genres, e.g. patient-pharmacist interactions, patient information leaflets, clinical trial protocols etc. This preliminary study is designed as an initial step to develop a description of vocabulary and phraseology, namely keywords, n-grams consisting of 4 words and phrase …
Deviance, did you get it? An experiment in reading to learn
1991
Abstract This article reports an experiment in which an attempt was made to test reading a scientific text under as natural study conditions as possible. After reading a lengthy text from a Sociology textbook in English, five out of 25 Finnish college students understood a basic concept the way it had been defined by a sociologist; 4 weeks later, after going over the text the second time in Finnish, the number increased to 12. However, even after the second reading of the text in their first language, only half of the students had learnt the basic concept. This indicates that the problems in studying were not only linguistic problems; they seem also to have been study skill problems in gene…
The Lithuanian "have" - resultative - a typological curiosum?
2012
ABSTRACT Björn Wiemer. The Lithuanian HAVE-resultative - A Typological Curiosum? Lingua Posnaniensis, vol. LIV (2)/2012. The Poznań Society for the Advancement of the Arts and Sciences. PL ISSN 0079-4740, ISBN 978-83-7654-252-2, pp. 69-81. This article presents the Lithuanian possessive resultative construction with the verb turėti ‘have’ and discusses its place in a typology of forms of resultative constructions. While possessive resultatives with a past passive participle (as in Polish Kolację mamy już przygotowaną lit. ‘We have the dinner already prepared’) are found in areally related as well as other languages, Lithuanian stands out in using an active participle (more precisely: a part…
Promoción de ciudades Patrimonio de la Humanidad: estudio sobre la traducción del léxico relacionado con la gastronomía
2019
[ES] Esta contribución presenta un estudio de traducción español-inglés basado en un corpus formado por las páginas web turísticas oficiales de las 15 ciudades españolas que hasta la fecha han sido declaradas Patrimonio Cultural Inmaterial de la Humanidad de la UNESCO. Nos centramos en la traducción de los referentes culturales y, más concretamente, en el léxico relacionado con la comida y la bebida. Las técnicas de traducción observadas se agrupan siguiendo propuestas de clasificación existentes en la literatura adaptadas a los referentes culturales. Los resultados obtenidos permiten llegar a conclusiones en cuanto a las tendencias de traducción (extranjerizantes o familiarizantes) en este…
Words, Corpus and Back to Words : From Language to Discourse
2018
The aim of this issue of is to bring together investigation into the lexicon in a variety of languages, in a diversity of manifestations – both at the word level and beyond the word level – and from a variety of perspectives, including not only those which focus on how the vocabulary is internally organized, but also those which deal with the role that lexical units and lexical relations play in the organization of other language levels, particularly in the organization of the discourse. These issues are approached from a variety of perspectives that include not only developments in several disciplines of theoretical and descriptive linguistics, particularly in lexicology, phraseology, word…