Search results for "Position"

Review Article: Recommended reading list of early publications on atomic layer deposition - Outcome of the "virtual Project on the History of ALD"

2017

Regulatory cytokine gene polymorphisms and risk of colorectal carcinoma.

2006

It is well established that cancer arises in chronically inflamed tissue, and this is particularly notable in the gastrointestinal tract. Classic examples include Helicobacter pylori-associated gastric cancer, hepatocellular carcinoma, and inflammatory bowel disease-associated colorectal cancer. Growing evidence suggests that these associations might be not casual findings. Focusing on individual cytokines has generated evidence that anti-inflammatory cytokine interleukin (IL)-10 and transforming growth factor-beta1 (TGF-beta1) may have a complex role in gastrointestinal carcinogenesis. As an example, IL-10-deficient mice develop severe atrophic gastritis and a chronic enterocolitis, develo…

Rare variant analyses across multiethnic cohorts identify novel genes for refractive error

2023

Refractive error, measured here as mean spherical equivalent (SER), is a complex eye condition caused by both genetic and environmental factors. Individuals with strong positive or negative values of SER require spectacles or other approaches for vision correction. Common genetic risk factors have been identified by genome-wide association studies (GWAS), but a great part of the refractive error heritability is still missing. Some of this heritability may be explained by rare variants (minor allele frequency [MAF] ≤ 0.01.). We performed multiple gene-based association tests of mean Spherical Equivalent with rare variants in exome array data from the Consortium for Refractive Error and Myopi…

SIRM–SIC appropriateness criteria for the use of Cardiac Computed Tomography. Part 1: Congenital heart diseases, primary prevention, risk assessment …

2021

AbstractIn the past 20 years, Cardiac Computed Tomography (CCT) has become a pivotal technique for the noninvasive diagnostic work-up of coronary and cardiac diseases. Continuous technical and methodological improvements, combined with fast growing scientific evidence, have progressively expanded the clinical role of CCT. Recent large multicenter randomized clinical trials documented the high prognostic value of CCT and its capability to increase the cost-effectiveness of the management of patients with suspected CAD. In the meantime, CCT, initially perceived as a simple non-invasive technique for studying coronary anatomy, has transformed into a multiparametric “one-stop-shop” approach abl…

Genome-wide association study and mouse expression data identify a highly conserved 32 kb intergenic region between WNT3 and WNT9b as possible suscep…

2014

Item does not contain fulltext Bladder exstrophy-epispadias complex (BEEC), the severe end of the urorectal malformation spectrum, has a profound impact on continence as well as sexual and renal functions. It is widely accepted that for the majority of cases the genetic basis appears to be multifactorial. Here, we report the first study which utilizes genome-wide association methods to analyze a cohort comprising patients presenting the most common BEEC form, classic bladder exstrophy (CBE), to identify common variation associated with risk for isolated CBE. We employed discovery and follow-up samples comprising 218 cases/865 controls and 78 trios in total, all of European descent. Our disc…

The behavior of Rare-Earth Elements, Zr and Hf during biologically-mediated deposition of silica-stromatolites and carbonate-rich microbial mats

2015

Abstract Venere Lake, in the Pantelleria Island thermal system (Central Mediterranean Sea) consists of a mix of seawater and hydrothermal volcanic fluids containing high levels of dissolved SiO 2 . Close to the lake's thermal springs, siliceous stromatolites are deposed under high bacterial activity conditions whereas roughly interlaminated Ca-carbonates and microbial mats are widely scattered in the lake. The dissolved REE speciation in lake waters is dominated by [REE(CO 3 ) 2 ] − , [REE(CO 3 )] + and [REE(H 3 SiO 4 )] 2 + complexes. On the contrary the most abundant Zr and Hf species are hydroxyl- and fluoride-complexes. The behavior of REE Zr and Hf in the Venere lake waters is controll…

On the formation of laminated sediments on the continental margin off Pakistan: the effects of sediment provenance and sediment redistribution

2001

Abstract The sedimentary processes and sediment sources contributing to the formation of laminated sediments along the upper slope off Pakistan are unravelled using inorganic bulk sediment geochemistry of 43 surface cores from the Pakistani continental margin and additional geochemical and Pb and Nd-isotope data for different types of layers. An important process everywhere along the margin is redeposition of fluvial-derived detritus from the shelf onto the slope. This process is of considerably higher intensity along the Makran margin than on the Indus margin. Trace element enrichment related to early diagenesis or surface productivity, which is commonly detectable in bulk sediment composi…

Soil and Plant Nitrogen Pools as Related to Plant Diversity in an Experimental Grassland

2007

Increasing plant species richness decreases soil NO 3 - concentrations in experimental plant mixtures, but the role of particular plant functional groups has remained unclear. Most analyses have focused on particular times of the year or were restricted to NO 3 - . We tested whether plant species richness or particular plant functional groups affect the size of plant-available N pools in soil (KCl-extractable NO 3 - , dissolved inorganic N and organic N [DON] and total dissolved N [TDN] in soil solution) and N concentrations and pools in aboveground biomass. Furthermore, we assessed seasonal variations in the effects of plant species richness and plant functional groups. The experimental gr…

Sm–Nd, Rb–Sr and Pb–Pb dating of silicic carbonates from the early Archaean Barberton Greenstone Belt, South Africa

1998

Abstract Two silicic carbonate sequences occurring in the Onverwacht Group (OG) and the overlying Fig Tree Group (FTG) of the early Archaean Barberton Greenstone Belt, South Africa, contain silicified dolomites with primary structures and textures. They occur with volcanic rocks dated by single zircons. The associated Onverwacht felsic volcanics have an age of ∼3440–3416 Ma, whereas the Fig Tree volcanics are ∼3225 Ma old. Therefore, the depositional age of both sequences is between 3440 and 3225 Ma. Pb-isotopic data for different parts of a single OG whole rock sample form a linear array corresponding to a Pb–Pb age of 2632±99 Ma. Sm–Nd and Rb–Sr isotopes were analysed in four whole rock s…

Zircon ages for a felsic volcanic rock and arc-related early Palaeozoic sediments on the margin of the Baydrag microcontinent, central Asian orogenic…

2011

Abstract Magmatic zircons from the basal part of an arc terrane in the accretionary complex NE of the Baydrag microcontinental block in central Mongolia were dated at 544 ± 7 Ma and reflect arc magmatism at the Ediacaran/Cambrian boundary. Detrital zircon ages for clastic metasediments of the adjacent Dzag zone suggest a depositional age