Search results for "Positioning"
showing 10 items of 256 documents
Peer-to-peer cooperative GNSS-based localization for stationary reference nodes in wireless sensor networks
2017
Most localization algorithms in wireless sensor networks rely on a few reference nodes with known locations to estimate the locations of unknown nodes. The locations of reference nodes can be either manually configured or, more practically, obtained by means of some satellite-based positioning system(s). However, satellite-based locations may be inaccurate and imprecise, which results in reduced location accuracy of localization algorithms. This paper proposes a peer-to-peer cooperative GNSS-based localization algorithm for stationary reference nodes to improve their relative location accuracy and precision. The algorithm applies simple statistical methods and GNSS-based information from mu…
Traffic data acquirement by unmanned aerial vehicle
2017
This paper presents a methodology aimed to acquire traffic flow data through the employment of unmanned aerial vehicles (UAVs). The study is focused on the determination of driving behavior parameters of road users and on the reconstruction of traffic flow Origin/Destination matrix. The methodology integrates UAV flights with video image processing technique, and the capability of geographic information systems, to represent spatiotemporal phenomena. In particular, analyzing different intersections, the attention of the authors is focused on users’ gap acceptance in a naturalistic drivers’ behavior condition (drivers are not influenced by the presence of instruments and operators on the roa…
Design of a modular Autonomous Underwater Vehicle for archaeological investigations
2015
MARTA (MARine Tool for Archaeology) is a modular AUV (Autonomous Underwater Vehicle) designed and developed by the University of Florence in the framework of the ARROWS (ARchaeological RObot systems for the World's Seas) FP7 European project. The ARROWS project challenge is to provide the underwater archaeologists with technological tools for cost affordable campaigns: i.e. ARROWS adapts and develops low cost AUV technologies to significantly reduce the cost of archaeological operations, covering the full extent of an archaeological campaign (underwater mapping, diagnosis and cleaning tasks). The tools and methodologies developed within ARROWS comply with the "Annex" of the 2001 UNESCO Conv…
A Geometrical Approach for Vision Based Attitude and Altitude Estimation for UAVs in Dark Environments
2012
International audience; This paper presents a single camera and laser system dedicated to the realtime estimation of attitude and altitude for unmanned aerial vehicles (UAV) under low illumination conditions to dark environments. The fisheye camera allows to cover a large field of view (FOV). The approach, close to structured light systems, uses the geometrical information obtained by the projection of a laser circle onto the ground plane and perceived by the camera. We propose some experiments based on simulated data and real sequences. The results show good agreement with the ground truth values from the commercial sensors in terms of its accuracy and correctness. The results also prove i…
Location-Aware MAC Scheduling in Industrial-Like Environment
2018
We consider an environment strongly affected by the presence of metallic objects, that can be considered representative of an indoor industrial environment with metal obstacles. This scenario is a very harsh environment where radio communication has notorious difficulties, as metallic objects create a strong blockage component and surfaces are highly reflective. In this environment, we investigate how to dynamically allocate MAC resources in time to static and mobile users based on context awareness extracted from a legacy WiFi positioning system. In order to address this problem, we integrate our WiFi ranging and positioning system in the WiSHFUL architecture and then define a hypothesis t…
β3-Adrenoceptor agonists for overactive bladder syndrome: Role of translational pharmacology in a repositioning clinical drug development project
2016
β3-Adrenoceptor agonists were originally considered as a promising drug class for the treatment of obesity and/or type 2 diabetes. When these development efforts failed, they were repositioned for the treatment of the overactive bladder syndrome. Based on the example of the β3-adrenoceptor agonist mirabegron, but also taking into consideration evidence obtained with ritobegron and solabegron, we discuss challenges facing a translational pharmacology program accompanying clinical drug development for a first-in-class molecule. Challenges included generic ones such as ligand selectivity, species differences and drug target gene polymorphisms. Challenges that are more specific included changin…
Cancer therapy and treatments during COVID-19 era
2020
The COVID-19 pandemic has put a serious strain on health treatments as well at the economies of many nations. Unfortunately, there is not currently available vaccine for SARS-Cov-2/COVID-19. Various types of patients have delayed treatment or even routine check-ups and we are adapting to a virtual world. In many cases, surgeries are delayed unless they are essential. This is also true with regards to cancer treatments and screening. Interestingly, some existing drugs and nutraceuticals have been screened for their effects on COVID-19. Certain FDA approved drugs, vitamin, natural products and trace minerals may be repurposed to treat or improve the prevention of COVID-19 infections and disea…
From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy.
2017
Artemisia annua L. is used throughout Asia and Africa as tea and press juice to treat malaria and related symptomes (fever, chills). Its active ingredient, artemisinin (ARS), has been developed as antimalarial drug and is used worldwide. Interestingly, the bioactivity is not restricted to malaria treatment. We and others found that ARS-type drugs also reveal anticancer in vitro and in vivo. In this review, we give a systematic overview of the literature published over the past two decades until the end of 2016. Like other natural products, ARS acts in a multi-specific manner against tumors. The cellular response of ARS and its derivatives (dihydroartemisinin, artesunate, artemether, arteeth…
Repurposing of plant alkaloids for cancer therapy: Pharmacology and toxicology.
2019
Drug repurposing (or repositioning) is an emerging concept to use old drugs for new treatment indications. Phytochemicals isolated from medicinal plants have been largely neglected in this context, although their pharmacological activities have been well investigated in the past, and they may have considerable potentials for repositioning. A grand number of plant alkaloids inhibit syngeneic or xenograft tumor growth in vivo. Molecular modes of action in cancer cells include induction of cell cycle arrest, intrinsic and extrinsic apoptosis, autophagy, inhibition of angiogenesis and glycolysis, stress and anti-inflammatory responses, regulation of immune functions, cellular differentiation, a…
Repurposing of artemisinin-type drugs for the treatment of acute leukemia.
2020
Cancer treatment represents an unmet challenge due to the development of drug resistance and severe side effects of chemotherapy. Artemisinin (ARS)-type compounds exhibit excellent antimalarial effects with few side effects and drug-resistance. ARS and its derivatives were also reported to act against various tumor types in vitro and in vivo, including acute leukemia. Therefore, ARS-type compounds may be exquisitely suitable for repurposing in leukemia treatment. To provide comprehensive clues of ARS and its derivatives for acute leukemia treatment, their molecular mechanisms are discussed in this review. Five monomeric molecules and 72 dimers, trimers and hybrids based on the ARS scaffold …