Search results for "Positioning"

Learning Structures in Earth Observation Data with Gaussian Processes

2020

Gaussian Processes (GPs) has experienced tremendous success in geoscience in general and for bio-geophysical parameter retrieval in the last years. GPs constitute a solid Bayesian framework to formulate many function approximation problems consistently. This paper reviews the main theoretical GP developments in the field. We review new algorithms that respect the signal and noise characteristics, that provide feature rankings automatically, and that allow applicability of associated uncertainty intervals to transport GP models in space and time. All these developments are illustrated in the field of geoscience and remote sensing at a local and global scales through a set of illustrative exa…

Statistical Performance Analysis of a Fast Super-Resolution Technique Using Noisy Translations.

2014

It is well known that the registration process is a key step for super-resolution reconstruction. In this work, we propose to use a piezoelectric system that is easily adaptable on all microscopes and telescopes for controlling accurately their motion (down to nanometers) and therefore acquiring multiple images of the same scene at different controlled positions. Then a fast super-resolution algorithm \cite{eh01} can be used for efficient super-resolution reconstruction. In this case, the optimal use of $r^2$ images for a resolution enhancement factor $r$ is generally not enough to obtain satisfying results due to the random inaccuracy of the positioning system. Thus we propose to take seve…

‘Can I tell?’ : Children’s participation and positioning in a secretive atmosphere in family therapy

2020

As a multifaceted phenomenon, family secrets affect interaction in the therapeutic system. This qualitative study, applying the multi‐actor Dialogical Methods for Investigations of Happening of Change, explored how children participated and positioned themselves in family therapy in a climate of family secrets. The results showed that the children were active co‐participants in the complex dynamics of a secretive atmosphere, involving themselves in the paradoxical processes of reconstructing and deconstructing the secretive and unsafe climate. In family therapy, a child’s symptomatic behaviour can function as a visible ‘cover story’ for invisible constructions of secrets, preventing sensiti…

A multi-layer method to study genome-scale positions of nucleosomes

2009

AbstractThe basic unit of eukaryotic chromatin is the nucleosome, consisting of about 150 bp of DNA wrapped around a protein core made of histone proteins. Nucleosomes position is modulated in vivo to regulate fundamental nuclear processes. To measure nucleosome positions on a genomic scale both theoretical and experimental approaches have been recently reported. We have developed a new method, Multi-Layer Model (MLM), for the analysis of nucleosome position data obtained with microarray-based approach. The MLM is a feature extraction method in which the input data is processed by a classifier to distinguish between several kinds of patterns. We applied our method to simulated-synthetic and…

Insights into the agency, positioning and development of professional Finnish language skills of international nursing students

2016

This article focuses on international students studying in an English-mediated nursing degree program in Finland. From sociocognitive and ecological perspectives, this study examines the development of the students’ professional Finnish language skills and agency during their practical training. In addition, this article explores how students are positioned as capable workers. To shed light on the students’ professional language skills, agency, and positionings, interviews with vocational teachers, head nurses, and two international nursing students are examined using narrative analysis. The findings suggest that due to their lack of Finnish language skills, international students are posit…

A pre-processing and network analysis of GPS tracking data

2020

Global Positioning System (GPS) devices afford the opportunity to collect accurate data on unit movements from temporal and spatial perspectives. With a special focus on GPS technology in travel surveys, this paper proposes: (1) two algorithms for the pre-processing of GPS data in order to deal with outlier identification and missing data imputation; (2) a clustering approach to recover the main points of interest from GPS trajectories; and (3) a weighted-directed network, which incorporates the most relevant characteristics of the GPS trajectories at an aggregate level. A simulation study shows the goodness-of-fit of the imputation data algorithm and the robustness of the clustering algori…

EGNOS augmented satellite positioning

2007

Disparity between Inter-Patient Molecular Heterogeneity and Repertoires of Target Drugs Used for Different Types of Cancer in Clinical Oncology

2020

Inter-patient molecular heterogeneity is the major declared driver of an expanding variety of anticancer drugs and personalizing their prescriptions. Here, we compared interpatient molecular heterogeneities of tumors and repertoires of drugs or their molecular targets currently in use in clinical oncology. We estimated molecular heterogeneity using genomic (whole exome sequencing) and transcriptomic (RNA sequencing) data for 4890 tumors taken from The Cancer Genome Atlas database. For thirteen major cancer types, we compared heterogeneities at the levels of mutations and gene expression with the repertoires of targeted therapeutics and their molecular targets accepted by the current guideli…

Exploring the SARS-CoV-2 Proteome in the Search of Potential Inhibitors via Structure-based Pharmacophore Modeling/Docking Approach

2020

To date, SARS-CoV-2 infectious disease, named COVID-19 by the World Health Organization (WHO) in February 2020, has caused millions of infections and hundreds of thousands of deaths. Despite the scientific community efforts, there are currently no approved therapies for treating this coronavirus infection. The process of new drug development is expensive and time-consuming, so that drug repurposing may be the ideal solution to fight the pandemic. In this paper, we selected the proteins encoded by SARS-CoV-2 and using homology modeling we identified the high-quality model of proteins. A structure-based pharmacophore modeling study was performed to identify the pharmacophore features for each…

Some Improvements on Relativistic Positioning Systems

2018

[EN] We make some considerations about Relativistic Positioning Systems (RPS). Four satellites are needed to position a user. First of all we define the main concepts. Errors should be taken into account. Errors depend on the Jacobian transformation matrix. Its Jacobian is proportional to the tetrahedron volume whose vertexes are the four tips of the receiver-satellite unit vectors. If the four satellites are seen by the user on a circumference in the sky, then, the Jacobian and the tetrahedron volume vanish. The users we consider are spacecraft. Spacecraft to be positioned cannot be close to a null Jacobian satellites-user configuration. These regions have to be avoided choosing an appropr…