Search results for "Positive"
showing 10 items of 1875 documents
Modification of antigen-encoding RNA increases stability, translational efficacy, and T-cell stimulatory capacity of dendritic cells.
2006
AbstractAdoptive transfer of dendritic cells (DCs) transfected with in vitro–transcribed, RNA-encoding, tumor-associated antigens has recently entered clinical testing as a promising approach for cancer immunotherapy. However, pharmacokinetic exploration of RNA as a potential drug compound and a key aspect of clinical development is still pending. While investigating the impact of different structural modifications of RNA molecules on the kinetics of the encoded protein in DCs, we identified components located 3′ of the coding region that contributed to a higher transcript stability and translational efficiency. With the use of quantitative reverse transcription–polymerase chain reaction (R…
Ontological representation of texts, and its applicationsin text analysis
2003
Masteroppgave i informasjons- og kommunikasjonsteknologi 2003 - Høgskolen i Agder, Grimstad For the management of a company, the need to know what people think of their products or services is becoming increasingly important in an increasingly competitive market. As the Internet can nearly be described as a digital mirror of events in the ”real“ world, being able to make sense of the semi structured nature of natural language texts published in this ubiquitous medium has received growing interest. The approach proposed in the thesis combines natural language processing and ontologies to represent elements in texts and relations between them. These relations are used to determine what terms …
Mixed l-/l1 fault detection observer design for positive switched systems with time-varying delay via delta operator approach
2014
Published version of an article in the journal: International Journal of Control, Automation and Systems. Also available from the publisher at: http://dx.doi.org/10.1007/s12555-013-0466-1 This paper investigates the problem of fault detection observer design for positive switched systems with time-varying delay via delta operator approach. A new fault sensitivity measure, called l-index, is proposed. The l- fault detection observer design and multi-objective l -/l1 fault detection observer design problems are addressed. Based on the average dwell time approach and the piecewise copositive type Lyapunov-Krasovskii functional method in delta domain, sufficient conditions for the existence of …
Short-Termism: A Step Forward Toward Long-Term Performance or a Dead End
2018
The debate around short-termism and its effects on the economic life, rather negative than positive, is far from ending, having academics, practitioners, and pundits arguing on this topic. The purpose of this paper is to determine if short-termism is part of the process of creating long-term performance (value) in an organization or it is harmful for harnessing performance, by presenting the definitions of the concept, who are the main promoters of short-termism, opinions of both academics and practitioners, and studies and examples that sustain on the one side the fact that short-termism encourages the manipulation of numbers in order to meet quarterly earnings, by cutting investments from…
Economic and Psychological Factors in Entrepreneurial Tendency
2011
In the actual context of global economical crisis, the research question we raised was: Which of the personality traits, formerly associated with entrepreneurship, remain sufficiently stable/strong to overcome the negative economic conditions? That was the starting point to propose experimental evaluation of the possible effect of certain factors such as the economical crisis context/information regarding the economy status and the personal perception regarding the money source/value as regards to the tendency of investing in a small business of the youngsters with a high Internal Locus of Control level.
From corona virus to corona crisis : the value of an analytical and geographical understanding of crisis
2020
Abstract The term ‘crisis’ is omnipresent. The current corona virus pandemic is perceived as the most recent example. However, the notion of crisis is increasingly deployed as a signifier of relevance, rather than as an analytical concept. Moreover, human geography has so far little contributed to the interdisciplinary crisis research field which is fixated on the temporal aspects of crisis but neglects its spatiality. Against this background, the first aim of the paper is to demonstrate the value of thinking about crisis analytically. Therefore, we introduce theoretical knowledge developed within a recently emerging literature on crisis management. Second, we demonstrate the relevance of i…
Justification of ethical considerations in health economics – Merging the theories of Niklas Luhmann and Charles Taylor
2012
Dealing with ethics in health economics on socio-philosophical grounds is not yet well established. This paper shows how a liaison between the system theory of Luhmann and the philosophy of Taylor can be used to analyze and justify the incorporation of ethical considerations into health economics. One rationale for the incorporation of ethical consideration into health economics is the deficiencies in capturing all relevant needs of health system participants with common (welfare) economics. A second reason why health economics should account for ethical values is the fact that its decisions are already based on implicit value judgments. The impact of our approach is exemplified by the conc…
De ungas uppfattningar om krig och fred
1985
Wahlstrom, R.: Youngsters' views on questions concerning war and peace. Nordisk Psykologi, 1985, 37 (4), 298–309. The paper is based on a study of 375 Finnish youngsters' views on questions concerning war and peace. These attitudes are examined in relation to the self-concept and moral development. The results show that girls apparently value peace more than boys do, that girls also participate in peace saving activities more than boys. For both sexes, moral development correlates with a positive attitude towards peace: he higher the moral stage, the more favourable the attitudes. A correlation between a strong self-concept and a favourable attitude towards peace was found only for the girl…
Rethinking Deinstitutionalization: Exploring the Boundary Conditions for Abandoning and Decoupling Highly Diffused and Institutionalized Practices
2020
Deinstitutionalization of taken-for-granted practices as a natural consequence of ever increasing entropy seems to directly contradict the major institutional thesis, namely, that over time isomorphic forces increase and, as a result, possibilities for deinstitutionalization decrease culminating in the impossibility of abandoning in highly institutionalized fields. We argue that the possibilities for deinstitutionalization have been overestimated in organizational literature and offer a revisited account of deinstitutionalization vs. institutional isomorphism and institutionalized vs. highly diffusing-but-not-institutionalized practices. A freedom for choice between alternative practices ex…
The Complexity of Value and the Evaluation of Complexity: Social Use Value and Multi-criteria Analysis
2018
The “challenge of complexity” is one of the many points of convergence between the Encyclical Laudato si’ and the evolution of post-modern scientific thought. This study aims to analyze how complexity represents the essential element of the profound renewal in the scientific paradigm of the discipline of evaluation, particularly in regard to the theory of value, the categories of value, and the instruments of multi-criteria evaluation. Some contemporary theories of value propose, in fact, a complex source of value, such as surpluses of energy and of information (Ecological Economics) or as the creative and synergistic combination of three surpluses, namely energetic and non-entropic, geneal…